Journal ArticleDOI
Recent advances in gel technologies for topical and transdermal drug delivery
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TLDR
This review aims to introduce the latest trends in transdermal drug delivery via traditional hydrogels and organogels and to provide insight into the latest gel types (proniosomal gels, emulgels, bigels and aerogels) as well as recent technologies for topical and transder mal drug delivery.Abstract:
Transdermal drug delivery systems are a constant source of interest because of the benefits that they afford in overcoming many drawbacks associated with other modes of drug delivery (i.e. oral, intravenous). Because of the impermeable nature of the skin, designing a suitable drug delivery vehicle that penetrates the skin barrier is challenging. Gels are semisolid formulations, which have an external solvent phase, may be hydrophobic or hydrophilic in nature, and are immobilized within the spaces of a three-dimensional network structure. Gels have a broad range of applications in food, cosmetics, biotechnology, pharmatechnology, etc. Typically, gels can be distinguished according to the nature of the liquid phase, for example, organogels (oleogels) contain an organic solvent, and hydrogels contain water. Recent studies have reported other types of gels for dermal drug application, such as proniosomal gels, emulgels, bigels and aerogels. This review aims to introduce the latest trends in transdermal drug delivery via traditional hydrogels and organogels and to provide insight into the latest gel types (proniosomal gels, emulgels, bigels and aerogels) as well as recent technologies for topical and transdermal drug delivery.read more
Citations
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Journal ArticleDOI
Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum Corneum
TL;DR: The progress and current status of the transdermal drug delivery field is detailed, numerous pharmaceutical developments which have been employed to overcome limitations associated with skin delivery systems are described and particular attention is paid to the emerging field of microneedle technologies.
Journal ArticleDOI
Permeation enhancer strategies in transdermal drug delivery
TL;DR: New controlled transdermal drug delivery systems (TDDS) technologies (electrically-based, structure-based and velocity-based) have been developed and commercialized for thetransdermal delivery of troublesome drugs.
Journal ArticleDOI
Synthesis and biomedical applications of aerogels: Possibilities and challenges
Hajar Maleki,Luísa Durães,Carlos A. García-González,Pasquale Del Gaudio,António Portugal,Morteza Mahmoudi,Morteza Mahmoudi +6 more
TL;DR: A comprehensive overview on the synthesis, processing and drying methods of the mostly investigated types of aerogels used in the biological and biomedical contexts, including silica aerogel, silica-polymer composites, polymeric and biopolymer aerogELs are provided.
Journal ArticleDOI
Film forming systems for topical and transdermal drug delivery
Kashmira Kathe,Harsha Kathpalia +1 more
TL;DR: Graphical Abstract After application of the film forming system to the skin, the composition of theFilm forming system changes significantly due to the loss of the volatile components of the vehicle which results in formation of residual transparent film on the skin surface.
BookDOI
Handbook of Encapsulation and Controlled Release
TL;DR: The Handbook of Encapsulation and Controlled Release as discussed by the authors covers the entire field, presenting the fundamental processes involved and exploring how to use those processes for different applications in industry, including microencapsulation.
References
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Journal ArticleDOI
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