Recent Advances on the Role of Cytokines in Atherosclerosis
TLDR
This review focuses on recent advances regarding the role of cytokines, with the exception of chemokines, in the development, progression, and complications of atherosclerosis.Abstract:
Atherosclerosis is a chronic inflammatory disease of the arterial wall driven by innate and adaptive immune responses Inflammation controls the development and the destabilization of arterial plaque Cells involved in the atherosclerotic process secrete and are activated by soluble factors, known as cytokines Important recent advances in the comprehension of the mechanisms of atherosclerosis have provided evidence for a dual role of cytokines: proinflammatory and T helper-1-related cytokines promote the development and progression of the disease, whereas antiinflammatory and regulatory T cell-related cytokines exert clear antiatherogenic activities This review focuses on recent advances regarding the role of cytokines, with the exception of chemokines, in the development, progression, and complications of atherosclerosisread more
Citations
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Journal ArticleDOI
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines.
Irene Maeve Rea,Irene Maeve Rea,Irene Maeve Rea,David Gibson,Victoria McGilligan,Susan E. McNerlan,H. Denis Alexander,Owen A. Ross,Owen A. Ross +8 more
TL;DR: Molecular pathways that appear to contribute to the immune imbalance and the cytokine dysregulation, which is associated with “inflammageing” or parainflammation are highlighted and suggested to delay age-related diseases and aging itself by suppressing pro-inflammatory molecular mechanisms or improving the timely resolution of inflammation.
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Animal Models of Atherosclerosis
TL;DR: The use of mouse models with the ability to turn on or delete proteins or cells in tissue specific and temporal manner will be very valuable as it becomes clear that different factors may influence different stages of lesion development.
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Biology of intracranial aneurysms: role of inflammation
Nohra Chalouhi,Muhammad Ali,Pascal Jabbour,Stavropoula Tjoumakaris,L. Fernando Gonzalez,Robert H. Rosenwasser,Walter J. Koch,Aaron S. Dumont +7 more
TL;DR: Preliminary data suggest that therapies targeting the inflammatory response may have efficacy in the future treatment of IA and further investigation is necessary to elucidate the precise role of inflammation in IA pathogenesis, which can be exploited to improve the prognosis of patients harboring IA.
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Interleukin-1 Beta as a Target for Atherosclerosis Therapy: Biological Basis of CANTOS and Beyond
TL;DR: In this paper, the experimental and clinical evidence reviewed here support interleukin-1 beta (IL-1β) as both a local vascular and systemic contributor in this regard.
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Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets.
TL;DR: The current understanding of the roles of different cytokines in atherosclerosis together with therapeutic approaches aimed at manipulating their actions are described.
References
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Journal ArticleDOI
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
Jochen Schmitz,Alexander Owyang,Elizabeth R. Oldham,Yaoli Song,Erin Murphy,Terril K. McClanahan,Gerard Zurawski,Mehrdad M. Moshrefi,Jinzhong Qin,Xiaoxia Li,Daniel M. Gorman,J. Fernando Bazan,Robert A. Kastelein +12 more
TL;DR: A member of theIL-1 family, IL-33, which mediates its biological effects via IL-1 receptor ST 2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T( H)2 cells is reported.
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Immunological and Inflammatory Functions of the Interleukin-1 Family
TL;DR: The IL-1 family includes members that suppress inflammation, both specifically within the IL-2 family but also nonspecifically for TLR ligands and the innate immune response.
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Cytokines in atherosclerosis: pathogenic and regulatory pathways.
Alain Tedgui,Ziad Mallat +1 more
TL;DR: Based on the current knowledge of the role of cytokines in atherosclerosis, some novel therapeutic strategies to combat this disease are proposed and the potential of circulating cytokine levels as biomarkers of coronary artery disease is discussed.
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IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.
TL;DR: The studies reveal that endogenous IL-6 plays a crucial antiinflammatory role in both local and systemic acute inflammatory responses by controlling the level of proinflammatory, but not antiinflammatory, cytokines, and that these antiinflammatory activities byIL-6 cannot be compensated for by IL-10 or other IL- 6 family members.
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SOCS proteins, cytokine signalling and immune regulation.
TL;DR: This review brings together data from recent studies on SOCS proteins and their role in immunity, and proposes a cohesive model of how cytokine signalling regulates immune-cell function.