Journal ArticleDOI
Recognition and management of acute kidney injury in the International Society of Nephrology 0by25 Global Snapshot: a multinational cross-sectional study
Ravindra L. Mehta,Emmanuel A. Burdmann,Jorge Cerdá,John Feehally,Fredric O. Finkelstein,Guillermo Garcia-Garcia,Mélanie Godin,Vivekanand Jha,Norbert Lameire,Nathan W. Levin,Andrew Lewington,Raúl Lombardi,Etienne Macedo,Michael V. Rocco,Eliah Aronoff-Spencer,Marcello Tonelli,Jing Zhang,Giuseppe Remuzzi,Giuseppe Remuzzi +18 more
TLDR
Common aetiological factors across all countries are identified, which might be amenable to a standardised approach for early recognition and treatment of acute kidney injury.About:
This article is published in The Lancet.The article was published on 2016-05-14. It has received 275 citations till now. The article focuses on the topics: Renal replacement therapy & Acute kidney injury.read more
Citations
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Journal ArticleDOI
Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy
Adeera Levin,Marcello Tonelli,Joseph V. Bonventre,Josef Coresh,Jo Ann Donner,Agnes B. Fogo,Caroline S. Fox,Ron T. Gansevoort,Hiddo J.L. Heerspink,Meg Jardine,Bertram L. Kasiske,Anna Köttgen,Matthias Kretzler,Andrew S. Levey,Valerie A. Luyckx,Ravindra L. Mehta,Orson W. Moe,Gregorio T. Obrador,Neesh Pannu,Chirag R. Parikh,Vlado Perkovic,Carol A. Pollock,Peter Stenvinkel,Katherine R. Tuttle,David C. Wheeler,Kai-Uwe Eckardt +25 more
TL;DR: An action plan and performance framework based on ten themes to strengthen CKD surveillance, tackle major risk factors for CKD, and enhance understanding of the genetic causes of CKD is presented.
Journal ArticleDOI
Global epidemiology and outcomes of acute kidney injury
Eric Hoste,John A. Kellum,Nicholas M. Selby,Alexander Zarbock,Paul M. Palevsky,Sean M. Bagshaw,Stuart L. Goldstein,Jorge Cerdá,Lakhmir S. Chawla +8 more
TL;DR: The global epidemiology of acute kidney injury is described and the influence of modifiable and non-modifiable AKI risk factors, delayed diagnosis, variation in diagnostic criteria and disparities in access to health care are also discussed.
Journal ArticleDOI
Incidence and outcomes of neonatal acute kidney injury (AWAKEN): a multicentre, multinational, observational cohort study.
Jennifer G. Jetton,Louis Boohaker,Sidharth K Sethi,Sanjay Wazir,Smriti Rohatgi,Danielle E. Soranno,Aftab S. Chishti,Robert P. Woroniecki,Cherry Mammen,Jonathan R. Swanson,Shanthy Sridhar,Craig S. Wong,Juan C. Kupferman,Russell Griffin,David J. Askenazi,David T. Selewski,Subrata Sarkar,Alison L. Kent,Jeffery Fletcher,Carolyn Abitbol,Marissa DeFreitas,Shahnaz Duara,Jennifer R. Charlton,Ronnie Guillet,Carl T. D'Angio,Ayesa Mian,Erin Rademacher,Maroun J. Mhanna,Rupesh Raina,Deepak Kumar,Namasivayam Ambalavanan,Ayse Akcan Arikan,Christopher J. Rhee,Stuart L. Goldstein,Amy T. Nathan,Alok Bhutada,Shantanu Rastogi,Elizabeth M. Bonachea,Susan E. Ingraham,John D. Mahan,Arwa Nada,Patrick D. Brophy,Tarah T. Colaizy,Jonathan M. Klein,F. Sessions Cole,T. Keefe Davis,Joshua Dower,Lawrence S. Milner,Alexandra Smith,Mamta Fuloria,Kimberly J. Reidy,Frederick Kaskel,Jason Gien,Katja M. Gist,Mina Hanna,Sangeeta Hingorani,Michelle C. Starr,Catherine Joseph,Tara DuPont,Robin K. Ohls,Amy Staples,Surender Khokhar,Sofia Perazzo,Patricio E. Ray,Mary Revenis,Anne Synnes,Pia Wintermark +66 more
TL;DR: Neonatal AKI is a common and independent risk factor for mortality and longer hospital stay, and data suggest that neonates may be impacted by AKI in a manner similar to pediatric and adult patients.
Journal ArticleDOI
PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury
Chengyuan Tang,Hailong Han,Mingjuan Yan,Shiyao Zhu,Jing Liu,Zhiwen Liu,Liyu He,Jieqiong Tan,Yu Liu,Hong Liu,Lin Sun,Shao-Bin Duan,Youming Peng,Fuyou Liu,Xiao Ming Yin,Zhuohua Zhang,Zheng Dong +16 more
TL;DR: It is shown thatmitophagy is induced in renal proximal tubular cells in both in vitro and in vivo models of ischemic AKI, indicating that PINK1-PARK2-mediated mitophagy plays an important role in mitochondrial quality control, tubular cell survival, and renal function during AKI.
Journal ArticleDOI
Management of patients at risk of acute kidney injury
TL;DR: Fuid management should aim for early, rapid restoration of circulatory volume, but should be more limited after the first 24-48 h to avoid volume overload, and use of balanced crystalloid solutions versus normal saline remains controversial.
References
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Journal ArticleDOI
Acute Renal Failure in Critically Ill Patients: A Multinational, Multicenter Study
Shigehiko Uchino,John A. Kellum,Rinaldo Bellomo,Gordon S. Doig,Hiroshi Morimatsu,Stanislao Morgera,Miet Schetz,Ian Tan,Catherine S. C. Bouman,Ettiene Macedo,Noel Gibney,Ashita Tolwani,Claudio Ronco +12 more
TL;DR: In this article, the period prevalence of acute renal failure (ARF) requiring renal replacement therapy (RRT) was found to be between 5% and 6% and was associated with a high hospital mortality rate.
Journal ArticleDOI
Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study
Eric Hoste,Eric Hoste,Eric Hoste,Sean M. Bagshaw,Rinaldo Bellomo,Cynthia M. Cely,Roos Colman,Dinna N. Cruz,Kyriakos Edipidis,Lui G. Forni,Charles D. Gomersall,Deepak Govil,Patrick M. Honore,Olivier Joannes-Boyau,Michael Joannidis,Anna-Maija Korhonen,Athina Lavrentieva,Ravindra L. Mehta,Paul M. Palevsky,Eric Roessler,Claudio Ronco,Shigehiko Uchino,Jorge A. Vazquez,Erick Vidal Andrade,Steve Webb,John A. Kellum +25 more
TL;DR: This is the first multinational cross-sectional study on the epidemiology of AKI in ICu patients using the complete KDIGO criteria and found that AKI occurred in more than half of ICU patients.
Journal ArticleDOI
Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis.
TL;DR: A systematic review of cohort studies evaluating long-term renal outcomes and non-renal outcomes in patients with and without AKI identifies AKI as an independent risk factor for CKD, ESRD, death, and other important non- renewable outcomes.
Journal ArticleDOI
Assessment of the worldwide burden of critical illness: The Intensive Care Over Nations (ICON) audit
Jean Louis Vincent,John C. Marshall,Silvio A. Ñamendys-Silva,Bruno François,Ignacio Martin-Loeches,Jeffrey Lipman,Konrad Reinhart,Massimo Antonelli,Peter Pickkers,Hassane Njimi,Edgar Jimenez,Yasser Sakr +11 more
TL;DR: In this article, the authors did an international audit of ICU patients worldwide and assessed variations between hospitals and countries in terms of the ICU mortality, showing that sepsis remains a major health problem worldwide, associated with high mortality rates in all countries.
Journal ArticleDOI
International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology
Ravindra L. Mehta,Jorge Cerdá,Emmanuel A. Burdmann,Marcello Tonelli,Guillermo Garcia-Garcia,Vivekanand Jha,Paweena Susantitaphong,Paweena Susantitaphong,Michael V. Rocco,Raymond Vanholder,Mehmet Sukru Sever,Dinna N. Cruz,Bertrand L. Jaber,Norbert Lameire,Raúl Lombardi,Andrew Lewington,John Feehally,Fredric O. Finkelstein,Nathan W. Levin,Neesh Pannu,Bernadette Thomas,Eliah Aronoff-Spencer,Giuseppe Remuzzi +22 more
TL;DR: The ability to provide lifesaving treatments for AKI provides a compelling argument to consider therapy forAKI as much of a basic right as it is to give antiretroviral drugs to treat HIV in low-resource regions, especially because care needs only be given for a Published Online March 13, 2015 http://dx.doi.org/10.1016/ S0140-6736(15)60126-X
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