Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group
Jens P. Dreier,Martin Fabricius,Cenk Ayata,Oliver W. Sakowitz,C. William Shuttleworth,Christian Dohmen,Christian Dohmen,Rudolf Graf,Peter Vajkoczy,Raimund Helbok,Michiyasu Suzuki,Alois Josef Schiefecker,Sebastian Major,Maren K.L. Winkler,Eun Jeung Kang,Denny Milakara,Ana I Oliveira-Ferreira,Clemens Reiffurth,Gajanan S. Revankar,Kazutaka Sugimoto,Nora F. Dengler,Nils Hecht,Brandon Foreman,Bart Feyen,Daniel Kondziella,Christian K. Friberg,Henning Piilgaard,Eric Rosenthal,M. Brandon Westover,Anna Maslarova,Edgar Santos,Daniel N. Hertle,Renán Sánchez-Porras,Sharon L. Jewell,Baptiste Balança,Baptiste Balança,Johannes Platz,Jason M. Hinzman,Janos Luckl,Karl Schoknecht,Michael Schöll,Christoph Drenckhahn,Delphine Feuerstein,Nina Eriksen,Viktor Horst,Julia S. Bretz,Paul Jahnke,Michael Scheel,Georg Bohner,Egill Rostrup,Bente Pakkenberg,Uwe Heinemann,Jan Claassen,Andrew P. Carlson,Christina M. Kowoll,Christina M. Kowoll,Svetlana Lublinsky,Yoash Chassidim,Ilan Shelef,Alon Friedman,Gerrit Brinker,Michael Reiner,Sergei A. Kirov,R. David Andrew,Eszter Farkas,Erdem Güresir,Hartmut Vatter,Lee S Chung,Kc Brennan,Thomas Lieutaud,Thomas Lieutaud,Stéphane Marinesco,Andrew I R Maas,Juan Sahuquillo,Markus Dahlem,Frank Richter,Oscar Herreras,Martyn G. Boutelle,David O. Okonkwo,M. Ross Bullock,Otto W. Witte,Peter Martus,Arn M. J. M. van den Maagdenberg,Michel D. Ferrari,Rick M. Dijkhuizen,Lori Shutter,Norberto Andaluz,André P. Schulte,Brian A. MacVicar,Tomas Watanabe,Johannes Woitzik,Martin Lauritzen,Anthony J. Strong,Jed A. Hartings +93 more
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TLDR
Consensus recommendations for electrocorticographic methods to record, classify, and score spreading depolarizations and associated spreading depressions are provided, which offer distinct advantages over other neuromonitoring modalities and allow for future refinement through less invasive and more automated approaches.Abstract:
Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable cerebral gray matter, and are a crucial mechanism of lesion development. Spreading depolarizations are increasingly recorded during multimodal neuromonitoring in neurocritical care as a causal biomarker providing a diagnostic summary measure of metabolic failure and excitotoxic injury. Focal ischemia causes spreading depolarization within minutes. Further spreading depolarizations arise for hours to days due to energy supply-demand mismatch in viable tissue. Spreading depolarizations exacerbate neuronal injury through prolonged ionic breakdown and spreading depolarization-related hypoperfusion (spreading ischemia). Local duration of the depolarization indicates local tissue energy status and risk of injury. Regional electrocorticographic monitoring affords even remote detection of injury because spreading depolarizations propagate widely from ischemic or metabolically stressed zones; characteristic patterns, including temporal clusters of spreading depolarizations and persistent depression of spontaneous cortical activity, can be recognized and quantified. Here, we describe the experimental basis for interpreting these patterns and illustrate their translation to human disease. We further provide consensus recommendations for electrocorticographic methods to record, classify, and score spreading depolarizations and associated spreading depressions. These methods offer distinct advantages over other neuromonitoring modalities and allow for future refinement through less invasive and more automated approaches.read more
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Journal ArticleDOI
Vascular Response to Spreading Depolarization Predicts Stroke Outcome
Nadine Binder,Chaim Glück,William Middleham,Michael Alasoadura,Nikolete Pranculeviciute,Matthias T. Wyss,Julien Chuquet,Bruno Weber,Susanne Wegener,Mohamad El Amki +9 more
TL;DR: The data show that modulating the hemodynamic response to CSD may be a promising therapeutic strategy to attenuate stroke outcome and show that different types of spreading hyperemia occur spontaneously after the onset of ischemia.
Journal ArticleDOI
Spectral and Multifractal Signature of Cortical Spreading Depolarisation in Aged Rats
TL;DR: Though the multifractal spectrum width proved to be a reliable indicator of events like CSDs or ischaemia onset, it was failed to find any case where it would add extra detail to the information provided by the Fourier description.
Journal ArticleDOI
Cortical Spreading Depression and Ischemia in Neurocritical Patients
TL;DR: Cortex spreading depolarization is associated with swelling of neurons, distortion of dendritic spines, massive ion translocation with a large change of the slow electrical potential, and silencing of brain electrical activity.
Journal ArticleDOI
Subdural Placement of Electrocorticographic Electrode Array Through a Burr Hole Exposure: 2-Dimensional Operative Video.
Franziska Meinert,Patrick Dömer,Simeon O. A. Helgers,Leonie Schumm,Nils Hecht,Jens P. Dreier,Johannes Woitzik +6 more
TL;DR: Meinert, Franziska MD*; Dömer, Patrick PhD*; Helgers, Simeon Oscar Arnulfo PhD* and Schumm, Leonie MD* as discussed by the authors .
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Titration of Pharmacological Responses in ICU Patients by Quantified EEG
TL;DR: In this paper , N.nan et al. presented a method to solve the problem of homonymity.http://www.nannan.edu.edu/blog/blogs/
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