Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group
Jens P. Dreier,Martin Fabricius,Cenk Ayata,Oliver W. Sakowitz,C. William Shuttleworth,Christian Dohmen,Christian Dohmen,Rudolf Graf,Peter Vajkoczy,Raimund Helbok,Michiyasu Suzuki,Alois Josef Schiefecker,Sebastian Major,Maren K.L. Winkler,Eun Jeung Kang,Denny Milakara,Ana I Oliveira-Ferreira,Clemens Reiffurth,Gajanan S. Revankar,Kazutaka Sugimoto,Nora F. Dengler,Nils Hecht,Brandon Foreman,Bart Feyen,Daniel Kondziella,Christian K. Friberg,Henning Piilgaard,Eric Rosenthal,M. Brandon Westover,Anna Maslarova,Edgar Santos,Daniel N. Hertle,Renán Sánchez-Porras,Sharon L. Jewell,Baptiste Balança,Baptiste Balança,Johannes Platz,Jason M. Hinzman,Janos Luckl,Karl Schoknecht,Michael Schöll,Christoph Drenckhahn,Delphine Feuerstein,Nina Eriksen,Viktor Horst,Julia S. Bretz,Paul Jahnke,Michael Scheel,Georg Bohner,Egill Rostrup,Bente Pakkenberg,Uwe Heinemann,Jan Claassen,Andrew P. Carlson,Christina M. Kowoll,Christina M. Kowoll,Svetlana Lublinsky,Yoash Chassidim,Ilan Shelef,Alon Friedman,Gerrit Brinker,Michael Reiner,Sergei A. Kirov,R. David Andrew,Eszter Farkas,Erdem Güresir,Hartmut Vatter,Lee S Chung,Kc Brennan,Thomas Lieutaud,Thomas Lieutaud,Stéphane Marinesco,Andrew I R Maas,Juan Sahuquillo,Markus Dahlem,Frank Richter,Oscar Herreras,Martyn G. Boutelle,David O. Okonkwo,M. Ross Bullock,Otto W. Witte,Peter Martus,Arn M. J. M. van den Maagdenberg,Michel D. Ferrari,Rick M. Dijkhuizen,Lori Shutter,Norberto Andaluz,André P. Schulte,Brian A. MacVicar,Tomas Watanabe,Johannes Woitzik,Martin Lauritzen,Anthony J. Strong,Jed A. Hartings +93 more
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Consensus recommendations for electrocorticographic methods to record, classify, and score spreading depolarizations and associated spreading depressions are provided, which offer distinct advantages over other neuromonitoring modalities and allow for future refinement through less invasive and more automated approaches.Abstract:
Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable cerebral gray matter, and are a crucial mechanism of lesion development. Spreading depolarizations are increasingly recorded during multimodal neuromonitoring in neurocritical care as a causal biomarker providing a diagnostic summary measure of metabolic failure and excitotoxic injury. Focal ischemia causes spreading depolarization within minutes. Further spreading depolarizations arise for hours to days due to energy supply-demand mismatch in viable tissue. Spreading depolarizations exacerbate neuronal injury through prolonged ionic breakdown and spreading depolarization-related hypoperfusion (spreading ischemia). Local duration of the depolarization indicates local tissue energy status and risk of injury. Regional electrocorticographic monitoring affords even remote detection of injury because spreading depolarizations propagate widely from ischemic or metabolically stressed zones; characteristic patterns, including temporal clusters of spreading depolarizations and persistent depression of spontaneous cortical activity, can be recognized and quantified. Here, we describe the experimental basis for interpreting these patterns and illustrate their translation to human disease. We further provide consensus recommendations for electrocorticographic methods to record, classify, and score spreading depolarizations and associated spreading depressions. These methods offer distinct advantages over other neuromonitoring modalities and allow for future refinement through less invasive and more automated approaches.read more
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Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research
Andrew I R Maas,David K. Menon,P. David Adelson,Nada Andelic,Michael J. Bell,Antonio Belli,Peter Bragge,Alexandra Brazinova,Andras Buki,Randall M. Chesnut,Giuseppe Citerio,Mark Coburn,D. Jamie Cooper,A Tamara Crowder,Endre Czeiter,Marek Czosnyka,Ramon Diaz-Arrastia,Jens P. Dreier,Ann-Christine Duhaime,Ari Ercole,Thomas A. van Essen,Valery L. Feigin,Guoyi Gao,Joseph T. Giacino,Laura E. Gonzalez-Lara,Russell L. Gruen,Russell L. Gruen,Deepak Gupta,Jed A. Hartings,Sean Hill,Jiyao Jiang,Naomi Ketharanathan,Erwin J. O. Kompanje,Linda Lanyon,Steven Laureys,Fiona Lecky,Harvey S. Levin,Hester F. Lingsma,Marc Maegele,Marek Majdan,Geoffrey T. Manley,Jill A. Marsteller,Luciana Mascia,Charles McFadyen,Stefania Mondello,Virginia F. J. Newcombe,Aarno Palotie,Aarno Palotie,Aarno Palotie,Paul M. Parizel,Wilco C. Peul,James Piercy,Suzanne Polinder,Louis Puybasset,Todd E. Rasmussen,Rolf Rossaint,Peter Smielewski,Jeannette Söderberg,Simon J. Stanworth,Murray B. 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References
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Endothelin-1-induced spreading depression in rats is associated with a microarea of selective neuronal necrosis.
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