Journal ArticleDOI
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.
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TLDR
Estimates can be used to more fully understand the redox biochemistry that results from oxidative stress, which hopefully will provide a rationale and understanding of the cellular mechanisms associated with cell growth and development, signaling, and reductive or oxidative stress.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2001-06-01. It has received 4274 citations till now. The article focuses on the topics: RoGFP & Redox.read more
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Glutathione half-cell reduction potential: A universal stress marker and modulator of programmed cell death?
TL;DR: It is put forward that this change in E(GSSG/2GSH) is part of the signaling cascade that initiates programmed cell death (PCD), finally causing internucleosomal DNA fragmentation in the final, or execution phase, of PCD.
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Glutathione, photosynthesis and the redox regulation of stress-responsive gene expression
TL;DR: This review draws on a number of recent important observations and papers to present a unified view of how the responsiveness of glutathione to changes in photosynthesis may be one means of linking changes in nuclear gene expression toChanges in the plant's external environment.
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A dual emission fluorescent probe enables simultaneous detection of glutathione and cysteine/homocysteine
Xiao-Feng Yang,Qian Huang,Yaogang Zhong,Zheng Li,Hua Li,Mark Lowry,Jorge O. Escobedo,Robert M. Strongin +7 more
TL;DR: A rhodol thioester that responds to GSH and Cys/Hcy with distinct fluorescence emissions in neutral media is reported and the utility of probe 1 has been demonstrated in various biological systems including serum and cells.
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Cell damage and reactive oxygen species production induced by fluorescence microscopy: effect on mitosis and guidelines for non-invasive fluorescence microscopy
Ram Dixit,Richard J. Cyr +1 more
TL;DR: In this article, the effect of light energy dose and observation conditions on tobacco BY-2 cell physiology was investigated, and a non-linear relationship between the excitation light intensity and mitotic arrest was found.
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Shell-Sheddable Micelles Based on Dextran-SS-Poly(ε-caprolactone) Diblock Copolymer for Efficient Intracellular Release of Doxorubicin
TL;DR: Reduction-responsive biodegradable micelles developed from disulfide-linked dextran-b-poly(epsilon-caprolactone) diblock copolymer and applied for triggered release of doxorubicin (DOX) in vitro and inside cells have appeared highly promising for the targeted intracellular delivery of hydrophobic chemotherapeutics in cancer therapy.
References
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Induction of apoptotic program in cell-free extracts : requirement for datp and cytochrome c
TL;DR: Cells undergoing apoptosis in vivo showed increased release of cy tochrome c to their cytosol, suggesting that mitochondria may function in apoptosis by releasing cytochrome c.
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The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
TL;DR: In this article, the authors used one-electron reduction potentials to predict a pecking order, or hierarchy, for free radical reactions, which is in agreement with experimentally observed free radical electron (hydrogen atom) transfer reactions.
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Oxidative stress as a mediator of apoptosis
Thomas M. Buttke,Paul Sandstrom +1 more
TL;DR: Thomas Buttke and Paul Sandstrom suggest that eukaryotic cells may benefit from this perilous existence by invoking oxidative stress as a common mediator of apoptosis.
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Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
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Oxidized redox state of glutathione in the endoplasmic reticulum
TL;DR: Results suggest that the demonstrated preferential transport of GSSG compared to GSH into the ER lumen may contribute to this redox compartmentation.