Journal ArticleDOI
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.
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TLDR
Estimates can be used to more fully understand the redox biochemistry that results from oxidative stress, which hopefully will provide a rationale and understanding of the cellular mechanisms associated with cell growth and development, signaling, and reductive or oxidative stress.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2001-06-01. It has received 4274 citations till now. The article focuses on the topics: RoGFP & Redox.read more
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Role of Oxidative Stress, Apoptosis, and Intracellular Homeostasis in Primary Cultures of Rat Proximal Tubular Cells Exposed to Cadmium
TL;DR: Exposure of rat proximal tubular cells to low-dose cadmium led to cellular death, mediated by an apoptotic and a necrotic mechanism, which may be mediated by oxidative stress.
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Cadmium-Induced Oxidative Stress: Focus on the Central Nervous System
Jacopo Junio Valerio Branca,Claudia Fiorillo,Donatello Carrino,Ferdinando Paternostro,Niccolò Taddei,Massimo Gulisano,Alessandra Pacini,Matteo Becatti +7 more
TL;DR: Cadmium can increase blood–brain barrier permeability and promotes Cd entry that, in turn, stimulates pericytes in maintaining the BBB open and accounts for the Cd deleterious effects and neurons inducing the destruction of synaptic branches.
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Folate and methionine metabolism in autism: a systematic review
TL;DR: It is concluded that further research is required with appropriately standardized and adequately powered study designs before any definitive conclusions can be made about the role for a dysfunctional folate-methionine pathway in the etiology of autism.
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Hyperbaric oxygen and chemical oxidants stimulate CO2/H+-sensitive neurons in rat brain stem slices.
TL;DR: It is concluded thathyperoxia decreases membrane conductance and stimulates firing of putative central CO2/H+-chemoreceptor neurons by an O2 free radical mechanism, which may explain why hyperoxia, paradoxically, stimulates ventilation.
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Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization
David Brown,Miguel A. Aon,Chad R. Frasier,Ruben C. Sloan,Andrew H. Maloney,Ethan J. Anderson,Brian O'Rourke +6 more
TL;DR: Findings show that oxidative stress induced by oxidation of GSH with diamide can cause electromechanical dysfunction under normoxic conditions and targeting the mitochondrial benzodiazepine receptor can prevent electrical and mechanical dysfunction in both models of oxidative stress.
References
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Induction of apoptotic program in cell-free extracts : requirement for datp and cytochrome c
TL;DR: Cells undergoing apoptosis in vivo showed increased release of cy tochrome c to their cytosol, suggesting that mitochondria may function in apoptosis by releasing cytochrome c.
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The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
TL;DR: In this article, the authors used one-electron reduction potentials to predict a pecking order, or hierarchy, for free radical reactions, which is in agreement with experimentally observed free radical electron (hydrogen atom) transfer reactions.
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Oxidative stress as a mediator of apoptosis
Thomas M. Buttke,Paul Sandstrom +1 more
TL;DR: Thomas Buttke and Paul Sandstrom suggest that eukaryotic cells may benefit from this perilous existence by invoking oxidative stress as a common mediator of apoptosis.
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Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
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Oxidized redox state of glutathione in the endoplasmic reticulum
TL;DR: Results suggest that the demonstrated preferential transport of GSSG compared to GSH into the ER lumen may contribute to this redox compartmentation.