Journal ArticleDOI
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.
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TLDR
Estimates can be used to more fully understand the redox biochemistry that results from oxidative stress, which hopefully will provide a rationale and understanding of the cellular mechanisms associated with cell growth and development, signaling, and reductive or oxidative stress.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2001-06-01. It has received 4274 citations till now. The article focuses on the topics: RoGFP & Redox.read more
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Journal ArticleDOI
The Utility of N,N-Biotinyl Glutathione Disulfide in the Study of Protein S-Glutathiolation
Jonathan P. Brennan,Jonathan I.A. Miller,William Fuller,Robin Wait,Shajna Begum,Michael J. Dunn,Philip Eaton +6 more
TL;DR: Biotin-GSSG is a useful tool in the investigation of protein S-glutathiolation and offers significant advantages over conventional methods or antibody-based strategies, and may find widespread utility in the study of disease or redox signaling models where GSSG accumulation occurs.
Journal ArticleDOI
Synergistic Cisplatin/Doxorubicin Combination Chemotherapy for Multidrug-Resistant Cancer via Polymeric Nanogels Targeting Delivery
Haiqiu Wu,Haojie Jin,Cun Wang,Zihao Zhang,Haoyu Ruan,Luyan Sun,Chen Yang,Yongjing Li,Wenxin Qin,Changchun Wang +9 more
TL;DR: The stimuli-responsive polymeric nanogels (<100 nm in size) based on poly(acrylic acid) were designed as codelivery system for doxorubicin and cisplatin to overcome drug resistance to achieve synergistic effect and minimize drug dose for cancer treatment in clinic application.
Journal ArticleDOI
Roles of reactive oxygen species in the fate of stem cells.
TL;DR: The various roles of ROS in adult, embryonic, and induced pluripotent stem cells are discussed andsecting the defined roles in distinct stem cell types will greatly enhance their basic and translational applications.
Book ChapterDOI
Endogenous Antioxidants and Radical Scavengers
Angela Maria Rizzo,Patrizia Berselli,Stefania Zava,Gigliola Montorfano,M. Negroni,Paola Antonia Corsetto,Bruno Berra +6 more
TL;DR: In this chapter only endogenous antioxidant molecules will be critically discussed, such as Glutathione, Alpha-lipoic acid, Coenzyme Q, Ferritin, Uric acid, Bilirubin, Metallothioneine, L-carnitine and Melatonin.
Journal ArticleDOI
Cysteine 111 Affects Aggregation and Cytotoxicity of Mutant Cu,Zn-superoxide Dismutase Associated with Familial Amyotrophic Lateral Sclerosis
Mauro Cozzolino,Ilaria Amori,Maria Grazia Pesaresi,Alberto Ferri,Monica Nencini,Maria Teresa Carrì +5 more
TL;DR: It is found that the removal of Cys-111 strongly reduces the ability of a range of different FALS-associated mutSOD1s to form aggregates and impair cell viability in cultured NSC-34 cells, consistent with the view that the redox environment influences the oligomerization/aggregation pathway of mutS OD1.
References
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Journal ArticleDOI
Induction of apoptotic program in cell-free extracts : requirement for datp and cytochrome c
TL;DR: Cells undergoing apoptosis in vivo showed increased release of cy tochrome c to their cytosol, suggesting that mitochondria may function in apoptosis by releasing cytochrome c.
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The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
TL;DR: In this article, the authors used one-electron reduction potentials to predict a pecking order, or hierarchy, for free radical reactions, which is in agreement with experimentally observed free radical electron (hydrogen atom) transfer reactions.
Journal ArticleDOI
Oxidative stress as a mediator of apoptosis
Thomas M. Buttke,Paul Sandstrom +1 more
TL;DR: Thomas Buttke and Paul Sandstrom suggest that eukaryotic cells may benefit from this perilous existence by invoking oxidative stress as a common mediator of apoptosis.
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Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
Journal ArticleDOI
Oxidized redox state of glutathione in the endoplasmic reticulum
TL;DR: Results suggest that the demonstrated preferential transport of GSSG compared to GSH into the ER lumen may contribute to this redox compartmentation.