Journal ArticleDOI
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.
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TLDR
Estimates can be used to more fully understand the redox biochemistry that results from oxidative stress, which hopefully will provide a rationale and understanding of the cellular mechanisms associated with cell growth and development, signaling, and reductive or oxidative stress.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2001-06-01. It has received 4274 citations till now. The article focuses on the topics: RoGFP & Redox.read more
Citations
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Letter to the Editor Metabolic Endophenotype and Related Genotypes are Associated With Oxidative Stress in Children With Autism
S. Jill James,Stepan Melnyk,Stefanie Jernigan,Mario A. Cleves,Charles H. Halsted,Donna H. Wong,Paul Cutler,Kenneth Bock,Marvin Boris,Sidney M. Baker,David W. Gaylor +10 more
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A Review on Surface-Enhanced Raman Scattering.
Roberto Pilot,Raffaella Signorini,Christian Durante,Laura Orian,Manjari Bhamidipati,Laura Fabris +5 more
TL;DR: An overview of the most significant aspects of surface-enhanced Raman scattering, and a representative selection of applications in the biomedical field, with direct and indirect protocols is provided.
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Fluorescent protein-based redox probes
Andreas J. Meyer,Tobias P. Dick +1 more
TL;DR: Genetically encoded redox probes enable the functional analysis of individual proteins in cellular redox homeostasis, and redox biosensor transgenic model organisms offer extended opportunities for dynamic in vivo imaging of redox processes.
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Uncoupling proteins and the control of mitochondrial reactive oxygen species production.
TL;DR: These findings are consistent with the notion that UCPs 2 and 3 are acutely activated by ROS, which then directly modulate the glutathionylation status of the UCP to decrease ROS emission and participate in cell signaling mechanisms.
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Energetics, epigenetics, mitochondrial genetics.
Douglas C. Wallace,Weiwei Fan +1 more
TL;DR: The clinical phenotypes of bioenergetic diseases are strikingly similar to those observed in epigenetic diseases (Angelman, Rett, Fragile X Syndromes, the laminopathies, cancer, etc.), and an increasing number of epigenetics diseases are being associated with mitochondrial dysfunction.
References
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Induction of apoptotic program in cell-free extracts : requirement for datp and cytochrome c
TL;DR: Cells undergoing apoptosis in vivo showed increased release of cy tochrome c to their cytosol, suggesting that mitochondria may function in apoptosis by releasing cytochrome c.
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The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
TL;DR: In this article, the authors used one-electron reduction potentials to predict a pecking order, or hierarchy, for free radical reactions, which is in agreement with experimentally observed free radical electron (hydrogen atom) transfer reactions.
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Oxidative stress as a mediator of apoptosis
Thomas M. Buttke,Paul Sandstrom +1 more
TL;DR: Thomas Buttke and Paul Sandstrom suggest that eukaryotic cells may benefit from this perilous existence by invoking oxidative stress as a common mediator of apoptosis.
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Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
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Oxidized redox state of glutathione in the endoplasmic reticulum
TL;DR: Results suggest that the demonstrated preferential transport of GSSG compared to GSH into the ER lumen may contribute to this redox compartmentation.