Journal ArticleDOI
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.
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TLDR
Estimates can be used to more fully understand the redox biochemistry that results from oxidative stress, which hopefully will provide a rationale and understanding of the cellular mechanisms associated with cell growth and development, signaling, and reductive or oxidative stress.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2001-06-01. It has received 4274 citations till now. The article focuses on the topics: RoGFP & Redox.read more
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Differential oxidation of thioredoxin-1, thioredoxin-2, and glutathione by metal ions.
TL;DR: Findings show that metals have differential oxidative effects on the major thiol antioxidant systems and that activation of apoptosis may be associated with metal ions that oxidize thioredoxin and activate ASK1.
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Chloroplasts as source and target of cellular redox regulation: a discussion on chloroplast redox signals in the context of plant physiology.
Margarete Baier,Karl-Josef Dietz +1 more
TL;DR: The signalling function is discussed in the context of regulatory circuitries that control the expression of antioxidant enzymes and redox modulators, demonstrating the principal role of chloroplasts as the source and target of redox regulation.
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A modulating role for antioxidants in desiccation tolerance.
Ilse Kranner,Simona Birtić +1 more
TL;DR: The failure of the antioxidant system during long-term desiccation appears to trigger programmed cell death, causing ageing and eventual death of the organism, which suggests that a potent antioxidant machinery is one of the underlying mechanisms of Desiccation tolerance.
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A review of natural antioxidants and their effects on oxidative status, odor and quality of fresh beef produced in Argentina
TL;DR: The implications of incorporating natural antioxidants into fresh beef, focusing on the benefits of feeding cattle good quality pasture, are reviewed, with Argentina having a natural advantage in producing meat with a high antioxidant value.
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Induction of apoptotic program in cell-free extracts : requirement for datp and cytochrome c
TL;DR: Cells undergoing apoptosis in vivo showed increased release of cy tochrome c to their cytosol, suggesting that mitochondria may function in apoptosis by releasing cytochrome c.
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The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
TL;DR: In this article, the authors used one-electron reduction potentials to predict a pecking order, or hierarchy, for free radical reactions, which is in agreement with experimentally observed free radical electron (hydrogen atom) transfer reactions.
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Oxidative stress as a mediator of apoptosis
Thomas M. Buttke,Paul Sandstrom +1 more
TL;DR: Thomas Buttke and Paul Sandstrom suggest that eukaryotic cells may benefit from this perilous existence by invoking oxidative stress as a common mediator of apoptosis.
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Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
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Oxidized redox state of glutathione in the endoplasmic reticulum
TL;DR: Results suggest that the demonstrated preferential transport of GSSG compared to GSH into the ER lumen may contribute to this redox compartmentation.