Journal ArticleDOI
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.
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TLDR
Estimates can be used to more fully understand the redox biochemistry that results from oxidative stress, which hopefully will provide a rationale and understanding of the cellular mechanisms associated with cell growth and development, signaling, and reductive or oxidative stress.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2001-06-01. It has received 4274 citations till now. The article focuses on the topics: RoGFP & Redox.read more
Citations
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Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
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How mitochondria produce reactive oxygen species.
TL;DR: The description outlined here facilitates the understanding of factors that favour mitochondrial ROS production and develops better methods to measure mitochondrial O2•− and H2O2 formation in vivo, as uncertainty about these values hampers studies on the role of mitochondrial ROS in pathological oxidative damage and redox signalling.
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Free radicals, metals and antioxidants in oxidative stress-induced cancer
TL;DR: This review examines the evidence for involvement of the oxidative stress in the carcinogenesis process and the role of enzymatic and non-enzymatic antioxidants in the process of carcinogenesis as well as the antioxidant interactions with various regulatory factors.
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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
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Reactive oxygen species, cellular redox systems and apoptosis
Magdalena L. Circu,Tak Yee Aw +1 more
TL;DR: A full understanding of the redox control of apoptotic initiation and execution could underpin the development of therapeutic interventions targeted at oxidative stress-associated disorders.
References
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Journal ArticleDOI
Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches
Irfan Rahman,William MacNee +1 more
TL;DR: The role of GSH levels in the regulation of transcription factors, whose activation and DNA binding leads to proinflammatory and antioxidant gene transcription is featured and the potential role of thiol antioxidants as a therapeutic approach in inflammatory lung diseases is discussed.
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Origin and turnover of mitochondrial glutathione.
Owen W. Griffith,Alton Meister +1 more
TL;DR: Mitochondrial glutathione in liver does not arise by intramitochondrial synthesis, but rather from the cytoplasm, by a process characterized by slow net transport and more rapid exchange transport.
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Glutathione measurement in human plasma. Evaluation of sample collection, storage and derivatization conditions for analysis of dansyl derivatives by HPLC.
Dean P. Jones,Joanne L Carlson,Paula S Samiec,Paul Sternberg,Vino C Mody,Robyn L Reed,Lou Ann S. Brown +6 more
TL;DR: In this paper, the authors developed a procedure to minimize error in sample collection, processing and storage that could contribute to human plasma GSH variation over 10-fold despite the use of apparently valid analytical procedures for GSH measurement.
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Hydrogen donor system for Escherichia coli ribonucleoside-diphosphate reductase dependent upon glutathione
TL;DR: The results demonstrate the existence of two different electron transfer systems from NADPH to deoxyribonucleotides and provide a function for glutathione in DNA synthesis in E. coli.