Journal ArticleDOI
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.
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TLDR
Estimates can be used to more fully understand the redox biochemistry that results from oxidative stress, which hopefully will provide a rationale and understanding of the cellular mechanisms associated with cell growth and development, signaling, and reductive or oxidative stress.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2001-06-01. It has received 4274 citations till now. The article focuses on the topics: RoGFP & Redox.read more
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Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
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How mitochondria produce reactive oxygen species.
TL;DR: The description outlined here facilitates the understanding of factors that favour mitochondrial ROS production and develops better methods to measure mitochondrial O2•− and H2O2 formation in vivo, as uncertainty about these values hampers studies on the role of mitochondrial ROS in pathological oxidative damage and redox signalling.
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Free radicals, metals and antioxidants in oxidative stress-induced cancer
TL;DR: This review examines the evidence for involvement of the oxidative stress in the carcinogenesis process and the role of enzymatic and non-enzymatic antioxidants in the process of carcinogenesis as well as the antioxidant interactions with various regulatory factors.
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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
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Reactive oxygen species, cellular redox systems and apoptosis
Magdalena L. Circu,Tak Yee Aw +1 more
TL;DR: A full understanding of the redox control of apoptotic initiation and execution could underpin the development of therapeutic interventions targeted at oxidative stress-associated disorders.
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Journal ArticleDOI
Cytochemical and quantitative study of protein-bound sulfhydryl and disulfide groups in eggs of Arbacia during the first cleavage
TL;DR: The results suggest that the spindle and astral fibers are composed of proteins rich in SH groups which arise from SS protein in the region of the centrosphere.
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Hyperoxic lung injury in Fischer-344 and Sprague-Dawley rats in vivo.
Joel D. Stenzel,Stephen E. Welty,Arthur E. Benzick,E. O'Brian Smith,Charles V. Smith,Thomas N. Hansen +5 more
TL;DR: It is concluded that the greater susceptibility of Fischer-344 than of Sprague-Dawley rats to hyperoxic lung injury in vitro reported previously also is observed in vivo and that this strain difference offers unique opportunities to study mechanisms of hyperoxia.
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Glutathione-dependent interconversion of microheterogeneous forms of glucose-6-phosphate dehydrogenase in rat liver.
Myeloperoxidase Is Involved in H 2 O 2 -induced Apoptosis of HL-60 Human Leukemia Cells*
TL;DR: In this paper, the authors examined the mechanism of H2O2-induced cytotoxicity and its relationship to oxidation in human leukemia cells, and concluded that the difference in H 2O2induced apoptosis might be due to the enzyme myeloperoxidase.