Journal ArticleDOI
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.
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TLDR
Estimates can be used to more fully understand the redox biochemistry that results from oxidative stress, which hopefully will provide a rationale and understanding of the cellular mechanisms associated with cell growth and development, signaling, and reductive or oxidative stress.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2001-06-01. It has received 4274 citations till now. The article focuses on the topics: RoGFP & Redox.read more
Citations
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Copper signalling: causes and consequences.
TL;DR: A deeper understanding of of the regulatory effects of copper on neuro-glia coupling via polyamine metabolism may reveal novel copper signalling functions and new directions for therapeutic intervention in brain disorders associated with aberrant copper metabolism.
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Stimuli-responsive polymers for anti-cancer drug delivery.
TL;DR: The developments in both endogenous stimuli - including redox-/pH-/enzyme-responsive polymers and exogenous stimuli- including thermo-/photo- and ultrasound- responsive polymers for delivery of anti-cancer drugs are reviewed.
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Ferric ion could facilitate osteoclast differentiation and bone resorption through the production of reactive oxygen species.
TL;DR: It is concluded that ferric ion can promote osteoclast differentiation and bone resorption through the production of ROS.
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Factors involved in root formation in Medicago truncatula
TL;DR: It was demonstrated that auxin NAA (1-naphthaleneacetic acid) pretreatment for 7 d can irreversibly interrupt somatic embryo formation, whilst both reduced and oxidized forms of glutathione enhance root formation via a mechanism independent of ethylene perception, as determined by analysis of the ethylene-insensitive skl mutant.
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Nonenzymatic displacement of chlorine and formation of free radicals upon the reaction of glutathione with PCB quinones.
TL;DR: The discovery that chlorinated quinones undergo a rapid, nonenzymatic dechlorination upon reaction with GSH opens a different view on mechanisms of metabolism and the toxicity of this class of compounds.
References
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Induction of apoptotic program in cell-free extracts : requirement for datp and cytochrome c
TL;DR: Cells undergoing apoptosis in vivo showed increased release of cy tochrome c to their cytosol, suggesting that mitochondria may function in apoptosis by releasing cytochrome c.
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The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
TL;DR: In this article, the authors used one-electron reduction potentials to predict a pecking order, or hierarchy, for free radical reactions, which is in agreement with experimentally observed free radical electron (hydrogen atom) transfer reactions.
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Oxidative stress as a mediator of apoptosis
Thomas M. Buttke,Paul Sandstrom +1 more
TL;DR: Thomas Buttke and Paul Sandstrom suggest that eukaryotic cells may benefit from this perilous existence by invoking oxidative stress as a common mediator of apoptosis.
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Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
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Oxidized redox state of glutathione in the endoplasmic reticulum
TL;DR: Results suggest that the demonstrated preferential transport of GSSG compared to GSH into the ER lumen may contribute to this redox compartmentation.