Journal ArticleDOI
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.
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TLDR
Estimates can be used to more fully understand the redox biochemistry that results from oxidative stress, which hopefully will provide a rationale and understanding of the cellular mechanisms associated with cell growth and development, signaling, and reductive or oxidative stress.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2001-06-01. It has received 4274 citations till now. The article focuses on the topics: RoGFP & Redox.read more
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Low brain glutathione and ascorbic acid associated with dopamine uptake inhibition during rat's development induce long-term cognitive deficit: relevance to schizophrenia.
TL;DR: The results suggest that low brain glutathione and ascorbic acid levels associated with a perturbation of the dopaminergic system actively participate in the development of some cognitive deficits affecting schizophrenic patients.
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Enhanced Glutathione Content Allows the In Vivo Synthesis of Fluorescent CdTe Nanoparticles by Escherichia coli
J. P. Monrás,J. P. Monrás,J. P. Monrás,Victor Díaz,Victor Díaz,Denisse Bravo,Rebecca A. Montes,Thomas G. Chasteen,Igor O. Osorio-Román,Claudio C. Vásquez,José M. Pérez-Donoso,José M. Pérez-Donoso +11 more
TL;DR: The intracellular CdTe QDs biosynthesis in bacteria using Escherichia coli overexpressing the gshA gene, involved in glutathione (GSH) biosynthesis, was used to produce Cd Te QDs.
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Molecular mechanism of glutathione-mediated protection from oxidized low-density lipoprotein-induced cell injury in human macrophages: role of glutathione reductase and glutaredoxin.
TL;DR: Data suggest that OxLDL promotes ROS formation and protein-S-glutathionylation by a mechanism independent from its effect on GSH depletion, and this work shows that supplementation of intracellular GSH stores with glutathione diethyl ester substantially diminishedOxLDL toxicity.
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Assessment of wound-site redox environment and the significance of Rac2 in cutaneous healing
Navdeep Ojha,Sashwati Roy,Guanglong He,Sabyasachi Biswas,Murugesan Velayutham,Savita Khanna,Periannan Kuppusamy,Jay L. Zweier,Chandan K. Sen +8 more
TL;DR: It is demonstrated that the wound site is rich in oxidants, the levels of which peak 2 days postwounding in the inflammatory phase, and Rac2 significantly contributes to oxidant production at the wounds site and supports the healing process.
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Copper chelation by D-penicillamine generates reactive oxygen species that are cytotoxic to human leukemia and breast cancer cells.
Anshul Gupte,Russell J. Mumper +1 more
TL;DR: Results support the hypothesis that D-pen can be employed as a cytotoxic copper-chelating agent based on its ROS-generating ability and reduce in intracellular reduced thiol levels.
References
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Induction of apoptotic program in cell-free extracts : requirement for datp and cytochrome c
TL;DR: Cells undergoing apoptosis in vivo showed increased release of cy tochrome c to their cytosol, suggesting that mitochondria may function in apoptosis by releasing cytochrome c.
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The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
TL;DR: In this article, the authors used one-electron reduction potentials to predict a pecking order, or hierarchy, for free radical reactions, which is in agreement with experimentally observed free radical electron (hydrogen atom) transfer reactions.
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Oxidative stress as a mediator of apoptosis
Thomas M. Buttke,Paul Sandstrom +1 more
TL;DR: Thomas Buttke and Paul Sandstrom suggest that eukaryotic cells may benefit from this perilous existence by invoking oxidative stress as a common mediator of apoptosis.
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Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
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Oxidized redox state of glutathione in the endoplasmic reticulum
TL;DR: Results suggest that the demonstrated preferential transport of GSSG compared to GSH into the ER lumen may contribute to this redox compartmentation.