Reduction in Human Papillomavirus (HPV) Prevalence Among Young Women Following HPV Vaccine Introduction in the United States, National Health and Nutrition Examination Surveys, 2003–2010
Lauri E. Markowitz,Susan Hariri,Carol Y. Lin,Eileen F. Dunne,Martin Steinau,Geraldine M. McQuillan,Elizabeth R. Unger +6 more
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TLDR
Within 4 years of vaccine introduction, the vaccine-type HPV prevalence decreased among females aged 14-19 years despite low vaccine uptake, and the estimated vaccine effectiveness was high.Abstract:
Background. Human papillomavirus (HPV) vaccination was introduced into the routine immunization schedule in the United States in late 2006 for females aged 11 or 12 years with catch-up vaccination recommended for those aged 13-26 years. In 2010 3-dose vaccine coverage was only 32% among 13-17 year-olds. Reduction in the prevalence of HPV types targeted by the quadrivalent vaccine (HPV-6 -11 -16 and -18) will be one of the first measures of vaccine impact. Methods. We analyzed HPV prevalence data from the vaccine era (2007-2010) and the prevaccine era (2003-2006) that were collected during National Health and Nutrition Examination Surveys. HPV prevalence was determined by the Linear Array HPV Assay in cervicovaginal swab samples from females aged 14-59 years; 4150 provided samples in 2003-2006 and 4253 provided samples in 2007-2010. Results. Among females aged 14-19 years the vaccine-type HPV prevalence (HPV-6 -11 -16 or -18) decreased from 11.5% (95% confidence interval [CI] 9.2-14.4) in 2003-2006 to 5.1% (95% CI 3.8-6.6) in 2007-2010 a decline of 56% (95% CI 38-69). Among other age groups the prevalence did not differ significantly between the 2 time periods (P > .05). The vaccine effectiveness of at least 1 dose was 82% (95% CI 53-93). Conclusions. Within 4 years of vaccine introduction the vaccine-type HPV prevalence decreased among females aged 14-19 years despite low vaccine uptake. The estimated vaccine effectiveness was high.read more
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Associations between human papillomavirus and history of cancer among U.S. adults in the National Health and Nutrition Examination Survey (2003–2010)
TL;DR: The finding of significant associations between HPV 16/18 seropositivity and lifetime history of cancer adds epidemiological evidence to the carcinogenicity potential of HPV 16 and 18 in other tissues.
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Current and future vaccine clinical research with the licensed 2-, 4-, and 9-valent VLP HPV vaccines: What's ongoing, what's needed?
TL;DR: Key questions being addressed in new trials include efficacy against persistent infection and immunogenicity of a 1-dose regimen; efficacy of 3 doses in 20-45-year-old females; use in postpartum women and immunocompromised individuals (HIV, liver and kidney transplants); dose sparing via intradermal administration; and use to prevent oropharyngeal cancer.
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Sex of Sexual Partners and Human Papillomavirus Vaccination Among U.S. Girls and Women.
Madina Agénor,Heather L. McCauley,Heather L. McCauley,Sarah M. Peitzmeier,Sebastien Haneuse,Allegra R. Gordon,Allegra R. Gordon,Jennifer Sharpe Potter,Jennifer Sharpe Potter,Jennifer Sharpe Potter,S. Bryn Austin,S. Bryn Austin +11 more
TL;DR: Medical and public health professionals should ensure that girls and women with only female or no sexual partners are included in HPV vaccine education and promotion efforts.
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Effectiveness of HPV vaccination in women reaching screening age in Italy
Francesca Carozzi,C. Ocello,Elena Burroni,Helena Faust,M. Zappa,E. Paci,A. Iossa,Paolo Bonanni,Massimo Confortini,Cristina Sani +9 more
TL;DR: The findings suggest that HPV vaccination at the age 25 is beneficial if it is offered to hr-HPV negative women, and a strong antibody response was observed not only for HPV 16 & 18 but also for their related types.
References
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Véronique Bouvard,Robert Baan,Kurt Straif,Yann Grosse,Béatrice Secretan,Fatiha El Ghissassi,Lamia Benbrahim-Tallaa,Neela Guha,Crystal Freeman,Laurent Galichet,Vincent Cogliano +10 more
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Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study
Silvia de Sanjosé,Wim Quint,Laia Alemany,D.T. Geraets,Jo Ellen Klaustermeier,Belen Lloveras,Sara Tous,Ana Félix,Luis Eduardo Bravo,Hai Rim Shin,Carlos S. Vallejos,Patricia Alonso de Ruiz,Marcus Aurelho Lima,Núria Guimerà,Omar Clavero,Maria Alejo,Antonio Llombart-Bosch,Chou Cheng-Yang,Silvio Tatti,Elena Kasamatsu,Ermina Iljazovic,Michael Odida,Rodrigo Prado,Muhieddine Seoud,Magdalena Grce,Alp Usubutun,Asha Jain,Gustavo Adolfo Hernandez Suarez,Luis Estuardo Lombardi,Aekunbiola Banjo,Clara Menendez,Efren J. Domingo,Julio Velasco,Ashrafun Nessa,Saibua Chichareon,You-Lin Qiao,Enrique Lerma,Suzanne M. Garland,Toshiyuki Sasagawa,Annabelle Ferrera,Doudja Hammouda,Luciano Mariani,Adela Pelayo,Ivo Šteiner,Esther Oliva,Chris J. L. M. Meijer,Waleed Al-Jassar,Eugenia Cruz,Thomas C. Wright,Ana Puras,Cecilia L. Llave,Maria Tzardi,Theodoros Agorastos,Victoria Garcia-Barriola,Christine Clavel,Jaume Ordi,Miguel Andújar,Xavier Castellsagué,Gloria I. Sanchez,Andrzej Nowakowski,Jacob Bornstein,Nubia Muñoz,F. Xavier Bosch +62 more
TL;DR: HPV types 16, 18, 31, 33, 35, 45, 52, and 58 should be given priority when the cross-protective effects of current vaccines are assessed, and for formulation of recommendations for the use of second-generation polyvalent HPV vaccines, according to this largest assessment of HPV genotypes to date.
Journal ArticleDOI
Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions
Luisa L. Villa,Gonzalo Perez,Susanne K. Kjaer,Jorma Paavonen,Matti Lehtinen,Nubia Muñoz,Kristjan Sigurdsson,Mauricio Hernández-Ávila,Finn Egil Skjeldestad,Steinar Thoresen,Patricia J. Garcia,Slawomir Majewski,Joakim Dillner,Sven Eric Olsson,Hseon Tay Eng,F. Xavier Bosch,Kevin A. Ault,Darron R. Brown,Daron G. Ferris,Laura A. Koutsky,Robert J. Kurman,Evan R. Myers,Eliav Barr,John W. Boslego,Janine T. Bryan,Mark T. Esser,Christine K. Gause,Teresa M. Hesley,Lisa Lupinacci,Heather L. Sings,Frank J. Taddeo,Annemarie R. Thornton +31 more
TL;DR: In young women who had not been previously infected with HPV-16 or HPV-18, those in the vaccine group had a significantly lower occurrence of high-grade cervical intraepithelial neoplasia related to HPV- 16 or HPV -18 than did those inThe placebo group.
Journal ArticleDOI
Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women.
Jorma Paavonen,Paulo Naud,Jorge Salmerón,Cosette M. Wheeler,Song-Nan Chow,D Apter,Henry C Kitchener,Xavier Castellsagué,Julio Cesar Teixeira,S R Skinner,James Hedrick,Unnop Jaisamrarn,Genara Limson,Suzanne M. Garland,Anne Szarewski,Barbara Romanowski,Fred Y. Aoki,Tino F. Schwarz,Willy Poppe,Franz X. Bosch,David Jenkins,Karin Hardt,Toufik Zahaf,Dominique Descamps,Frank Struyf,Matti Lehtinen,Gary Dubin +26 more
TL;DR: The HPV- 16/18 AS04-adjuvanted vaccine showed high efficacy against CIN2+ associated with HPV-16/18 and non-vaccine oncogenic HPV types and substantial overall effect in cohorts that are relevant to universal mass vaccination and catch-up programmes.
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