Reduction in Human Papillomavirus (HPV) Prevalence Among Young Women Following HPV Vaccine Introduction in the United States, National Health and Nutrition Examination Surveys, 2003–2010
Lauri E. Markowitz,Susan Hariri,Carol Y. Lin,Eileen F. Dunne,Martin Steinau,Geraldine M. McQuillan,Elizabeth R. Unger +6 more
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TLDR
Within 4 years of vaccine introduction, the vaccine-type HPV prevalence decreased among females aged 14-19 years despite low vaccine uptake, and the estimated vaccine effectiveness was high.Abstract:
Background. Human papillomavirus (HPV) vaccination was introduced into the routine immunization schedule in the United States in late 2006 for females aged 11 or 12 years with catch-up vaccination recommended for those aged 13-26 years. In 2010 3-dose vaccine coverage was only 32% among 13-17 year-olds. Reduction in the prevalence of HPV types targeted by the quadrivalent vaccine (HPV-6 -11 -16 and -18) will be one of the first measures of vaccine impact. Methods. We analyzed HPV prevalence data from the vaccine era (2007-2010) and the prevaccine era (2003-2006) that were collected during National Health and Nutrition Examination Surveys. HPV prevalence was determined by the Linear Array HPV Assay in cervicovaginal swab samples from females aged 14-59 years; 4150 provided samples in 2003-2006 and 4253 provided samples in 2007-2010. Results. Among females aged 14-19 years the vaccine-type HPV prevalence (HPV-6 -11 -16 or -18) decreased from 11.5% (95% confidence interval [CI] 9.2-14.4) in 2003-2006 to 5.1% (95% CI 3.8-6.6) in 2007-2010 a decline of 56% (95% CI 38-69). Among other age groups the prevalence did not differ significantly between the 2 time periods (P > .05). The vaccine effectiveness of at least 1 dose was 82% (95% CI 53-93). Conclusions. Within 4 years of vaccine introduction the vaccine-type HPV prevalence decreased among females aged 14-19 years despite low vaccine uptake. The estimated vaccine effectiveness was high.read more
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Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes : updated systematic review and meta-analysis
Mélanie Drolet,Élodie Bénard,Norma Pérez,Marc Brisson,Marc Brisson,Hammad Ali,Marie-Claude Boily,Vincenzo Baldo,Paul Brassard,Julia M.L. Brotherton,Denton Callander,Marta Checchi,Eric P F Chow,Silvia Cocchio,Tina Dalianis,Shelley L Deeks,Christian Dehlendorff,Basil Donovan,Christopher K Fairley,Elaine W. Flagg,Julia W Gargano,Suzanne M. Garland,Nathalie Grün,Bo T. Hansen,Christopher Harrison,Eva Herweijer,Teresa M. Imburgia,Anne M Johnson,Jessica A. Kahn,Kimberley Kavanagh,Susanne K. Kjaer,Erich V. Kliewer,Bette Liu,Dorothy A Machalek,Lauri E. Markowitz,David Mesher,Christian Munk,Linda M. Niccolai,Mari Nygård,Gina Ogilvie,Jeannie Oliphant,Kevin G.J. Pollock,Maria Jesús Purriños-Hermida,Megan Smith,Marc Steben,Anna Söderlund-Strand,Pam Sonnenberg,Pär Sparén,Clare Tanton,Cosette M. Wheeler,Petra J Woestenberg,Bo Nancy Yu +51 more
TL;DR: The results show compelling evidence of the substantial impact of HPV vaccination programmes on HPV infections and CIN2+ among girls and women, and on anogenital warts diagnoses among girls, women, boys, and men.
Journal ArticleDOI
Sexually Transmitted Infections Treatment Guidelines,2021
Kimberly A. Workowski,Laura H. Bachmann,Philip A. Chan,Christine Johnston,Christina A. Muzny,Ina U. Park,Hilary Reno,Jonathan M. Zenilman,Gail Bolan +8 more
TL;DR: These guidelines for the treatment of persons who have or are at risk for sexually transmitted infections (STIs) were updated by CDC after consultation with professionals knowledgeable in the field of STIs who met in Atlanta, Georgia, June 11-14, 2019.
Journal ArticleDOI
Population-level impact and herd effects following human papillomavirus vaccination programmes: a systematic review and meta-analysis
Mélanie Drolet,Élodie Bénard,Marie-Claude Boily,Marie-Claude Boily,Hammad Ali,Louise Baandrup,Heidi M. Bauer,Simon Beddows,Jacques Brisson,Julia M.L. Brotherton,Teresa Cummings,Basil Donovan,Christopher K Fairley,Elaine W. Flagg,Anne M Johnson,Jessica A. Kahn,Kimberley Kavanagh,Susanne K. Kjaer,Erich V. Kliewer,Philippe Lemieux-Mellouki,Lauri E. Markowitz,Aminata Mboup,David Mesher,Linda M. Niccolai,Jeannie Oliphant,Kevin G.J. Pollock,Kate Soldan,Pam Sonnenberg,Sepehr N. Tabrizi,Sepehr N. Tabrizi,Clare Tanton,Marc Brisson,Marc Brisson +32 more
TL;DR: The results are promising for the long-term population-level effects of HPV vaccination programmes, however, continued monitoring is essential to identify any signals of potential waning efficacy or type-replacement.
Journal ArticleDOI
Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors
TL;DR: Efficacy endpoints by initial HPV DNA statushrHPV negativeHPV vaccines reduce CIN2+, CIN3+, AIS associated with HPV16/18 compared with placebo in adolescent girls and women aged 15 to 26 and most women were under 26 years of age.
Population-level impact and herd effects following human papillomavirus vaccination programmes: a systematic review and meta-analysis
Mélanie Drolet,Élodie Bénard,Marie-Claude Boily,Hammad Ali,Louise Baandrup,Simon Beddows,Jacques Brisson,Julia M.L. Brotherton,Teresa Cummings,Basil Donovan,Christopher K Fairley,Elaine W. Flagg,Anne M Johnson,Jessica A. Kahn,Kimberley Kavanagh,Susanne K. Kjaer,Erich V. Kliewer,Philippe Lemieux-Mellouki,Lauri E. Markowitz,Aminata Mboup,David Mesher,Linda M. Niccolai,Jeannie Oliphant,Kevin G.J. Pollock,Kate Soldan,Pam Sonnenberg,Sepehr N. Tabrizi,Clare Tanton,Marc Brisson +28 more
TL;DR: A systematic review and meta-analysis to assess the population-level consequences and herd effects after female HPV vaccination programs, to verify whether or not the high efficacy reported in randomised controlled clinical trials are materialising in real-world situations is materializing in realworld situations.
References
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Véronique Bouvard,Robert Baan,Kurt Straif,Yann Grosse,Béatrice Secretan,Fatiha El Ghissassi,Lamia Benbrahim-Tallaa,Neela Guha,Crystal Freeman,Laurent Galichet,Vincent Cogliano +10 more
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Journal ArticleDOI
Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions
Luisa L. Villa,Gonzalo Perez,Susanne K. Kjaer,Jorma Paavonen,Matti Lehtinen,Nubia Muñoz,Kristjan Sigurdsson,Mauricio Hernández-Ávila,Finn Egil Skjeldestad,Steinar Thoresen,Patricia J. Garcia,Slawomir Majewski,Joakim Dillner,Sven Eric Olsson,Hseon Tay Eng,F. Xavier Bosch,Kevin A. Ault,Darron R. Brown,Daron G. Ferris,Laura A. Koutsky,Robert J. Kurman,Evan R. Myers,Eliav Barr,John W. Boslego,Janine T. Bryan,Mark T. Esser,Christine K. Gause,Teresa M. Hesley,Lisa Lupinacci,Heather L. Sings,Frank J. Taddeo,Annemarie R. Thornton +31 more
TL;DR: In young women who had not been previously infected with HPV-16 or HPV-18, those in the vaccine group had a significantly lower occurrence of high-grade cervical intraepithelial neoplasia related to HPV- 16 or HPV -18 than did those inThe placebo group.
Journal ArticleDOI
Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women.
Jorma Paavonen,Paulo Naud,Jorge Salmerón,Cosette M. Wheeler,Song-Nan Chow,D Apter,Henry C Kitchener,Xavier Castellsagué,Julio Cesar Teixeira,S R Skinner,James Hedrick,Unnop Jaisamrarn,Genara Limson,Suzanne M. Garland,Anne Szarewski,Barbara Romanowski,Fred Y. Aoki,Tino F. Schwarz,Willy Poppe,Franz X. Bosch,David Jenkins,Karin Hardt,Toufik Zahaf,Dominique Descamps,Frank Struyf,Matti Lehtinen,Gary Dubin +26 more
TL;DR: The HPV- 16/18 AS04-adjuvanted vaccine showed high efficacy against CIN2+ associated with HPV-16/18 and non-vaccine oncogenic HPV types and substantial overall effect in cohorts that are relevant to universal mass vaccination and catch-up programmes.
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