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Open AccessJournal ArticleDOI

Ret-dependent and -independent Mechanisms of Glial Cell Line-derived Neurotrophic Factor Signaling in Neuronal Cells

Miles Trupp, +3 more
- 23 Jul 1999 - 
- Vol. 274, Iss: 30, pp 20885-20894
TLDR
Compared signaling pathways activated by GDNF in two neuronal cell lines expressing different complements of GDNF receptors are compared to indicate the existence of novel signaling mechanisms directly or indirectly mediated by GFRα receptors acting in a cell-autonomous manner independently of Ret.
About: 
This article is published in Journal of Biological Chemistry.The article was published on 1999-07-23 and is currently open access. It has received 325 citations till now. The article focuses on the topics: GDNF family of ligands & Glial cell line-derived neurotrophic factor.

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Citations
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Journal ArticleDOI

Lipid rafts and signal transduction

Kai Simons, +1 more
- 01 Oct 2000 - 
TL;DR: It is now becoming clear that lipid micro-environments on the cell surface — known as lipid rafts — also take part in this process of signalling transduction, where protein–protein interactions result in the activation of signalling cascades.
Journal ArticleDOI

The GDNF family: Signalling, biological functions and therapeutic value

Matti S. Airaksinen, +1 more
- 01 May 2002 - 
TL;DR: Members of the nerve growth factor and glial cell line-derived neurotrophic factor families — comprising neurotrophins and GDNF-family ligands (GFLs) — are crucial for the development and maintenance of distinct sets of central and peripheral neurons.
Journal ArticleDOI

Novel functions and signalling pathways for GDNF

Hannu Sariola, +1 more
- 01 Oct 2003 - 
TL;DR: Glial-cell-line-derived neurotrophic factor (GDNF) was originally identified as a survival factor for midbrain dopaminergic neurons but has further critical roles outside the nervous system in the regulation of kidney morphogenesis and spermatogenesis.
Journal ArticleDOI

The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands.

Gustavo Paratcha, +2 more
- 27 Jun 2003 - 
TL;DR: The results uncover an unexpected intersection between short- and long-range mechanisms of intercellular communication and reveal a pathway for GDNF signaling that does not require the RET receptor.
Journal ArticleDOI

Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury.

J. Gordon Boyd, +1 more
- 01 Jun 2003 - 
TL;DR: Evidence is beginning to emerge that similar phenomena observed in vitro also apply to nerve regeneration in vivo, and the temporal pattern of expression of the neurotrophic factors and their receptors by axotomized motoneurons as well as in the distal nerve stump after peripheral nerve injury.
References
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Journal ArticleDOI

Functional rafts in cell membranes

Kai Simons, +1 more
- 05 Jun 1997 - 
TL;DR: A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer that function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.
Journal ArticleDOI

GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons

Leu-Fen H. Lin, +4 more
- 21 May 1993 - 
TL;DR: In embryonic midbrain cultures, recombinant human GDNF promoted the survival and morphological differentiation of dopaminergic neurons and increased their high-affinity dopamine uptake and did not increase total neuron or astrocyte numbers or transmitter uptake.
Journal ArticleDOI

Functions of lipid rafts in biological membranes.

Deborah A. Brown, +1 more
- 01 Jan 1998 - 
TL;DR: The relationship between detergent-resistant membranes, rafts, caveolae, and low-density plasma membrane fragments, and possible functions of lipid rafts in membranes are discussed.
Journal ArticleDOI

Cellular functions regulated by src family kinases

Sheila M. Thomas, +1 more
- 01 Jan 1997 - 
TL;DR: This chapter reviews the evidence implicating Src family kinases in specific receptor pathways and describes the mechanisms leading to their activation, the targets that interact with these kinases, and the biological events that they regulate.
Journal ArticleDOI

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor STUDY OF Lck- AND FynT-DEPENDENT T CELL ACTIVATION

Jeffrey Herbert Hanke, +7 more
- 12 Jan 1996 - 
TL;DR: This compound offers a useful new tool for examining the role of the Lck and FynT tyrosine kinases versus ZAP-70 in T cell activation as well as the roles of other Src family kinases in receptor function.
Related Papers (5)

GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons

Leu-Fen H. Lin, +4 more
- 21 May 1993 - 

GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF

Shuqian Jing, +13 more
- 28 Jun 1996 - 

Characterization of a multicomponent receptor for GDNF

James J.S. Treanor, +19 more
- 04 Jul 1996 - 

The GDNF family: Signalling, biological functions and therapeutic value

Matti S. Airaksinen, +1 more
- 01 May 2002 - 

Renal and neuronal abnormalities in mice lacking GDNF.

Mark W. Moore, +9 more
- 04 Jul 1996 -