RIP3: a molecular switch for necrosis and inflammation.
TLDR
The current understanding of the mechanisms that drive RIP3-dependent necrosis and its role in different inflammatory diseases is reviewed.Abstract:
The receptor-interacting protein kinase 3 (RIP3/RIPK3) has emerged as a critical regulator of programmed necrosis/ necroptosis, an inflammatory form of cell death with important functions in pathogen-induced and sterile inflammation. RIP3 activation is tightly regulated by phosphorylation, ubiquitination, and caspase-mediated cleavage. These post-translational modifications coordinately regulate the assembly of a macromolecular signaling complex termed the necrosome. Recently, several reports indicate that RIP3 can promote inflammation independent of its pronecrotic activity. Here, we review our current understanding of the mechanisms that drive RIP3-dependent necrosis and its role in different inflammatory diseases.read more
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Patent
Oncolytic vaccinia virus mutants and using same for cancer treatment
Bertram Jacobs,Heather Koehler,William Arndt,Karen Kibler,Kelly Trainor,Chandra Mitnik,Jeffrey Langland +6 more
TL;DR: In this article, the authors used vaccinia virus with mutations in E3L to infect and cause lysis of cancer cells with less than normal protein levels of RIP3 and/or DAI.
Journal ArticleDOI
Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression.
Nívea F. Luz,Ricardo Khouri,Ricardo Khouri,Johan Van Weyenbergh,Johan Van Weyenbergh,Dalila Luciola Zanette,Dalila Luciola Zanette,Paloma P. Fiuza,Almerio Noronha,Aldina Barral,Aldina Barral,Viviane Boaventura,Viviane Boaventura,Deboraci B. Prates,Deboraci B. Prates,Francis Ka-Ming Chan,Bruno B. Andrade,Bruno B. Andrade,Valéria M. Borges,Valéria M. Borges +19 more
TL;DR: Assays using infected macrophages demonstrated that the parasite deactivates both RIPK3 and MLKL expression and that these molecules are important to control the intracellular L. braziliensis replication.
Journal ArticleDOI
Methionine Restriction Prevents Lipopolysaccharide-Induced Acute Lung Injury via Modulating CSE/H2S Pathway
Jia-Qi Duan,Lun-li Xiang,Zhen P. Yang,Li Chen,Jianteng Gu,Kaizhi Lu,Daqing Ma,Hai-jian Zhao,Bin Yi,Hongwen Zhao,Jiaolin Ning +10 more
TL;DR: It is found that MR attenuated LPS-induced pulmonary edema, hemorrhage, atelectasis, and alveolar epithelial cell injuries in mice and suggests that developing MR towards clinical use for ALI/ARDS patients may be a valuable strategy.
DissertationDOI
Dendritic Cells Mediate Protective Immunity Against Salmonella Typhimurium by Regulating Antigen Presentation, Inflammation and Cell Death
TL;DR: This book aims to provide a history of web exceptionalism from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which descriptions of “Web 2.0” began to circulate.
Journal ArticleDOI
Human Cytomegalovirus-Induced Autophagy Prevents Necroptosis of Infected Monocytes.
TL;DR: Data indicate that HCMV induces autophagy to prevent necroptotic cell death in order to ensure the survival of infected monocytes and thus facilitate viral dissemination within the host.
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