RIP3: a molecular switch for necrosis and inflammation.
TLDR
The current understanding of the mechanisms that drive RIP3-dependent necrosis and its role in different inflammatory diseases is reviewed.Abstract:
The receptor-interacting protein kinase 3 (RIP3/RIPK3) has emerged as a critical regulator of programmed necrosis/ necroptosis, an inflammatory form of cell death with important functions in pathogen-induced and sterile inflammation. RIP3 activation is tightly regulated by phosphorylation, ubiquitination, and caspase-mediated cleavage. These post-translational modifications coordinately regulate the assembly of a macromolecular signaling complex termed the necrosome. Recently, several reports indicate that RIP3 can promote inflammation independent of its pronecrotic activity. Here, we review our current understanding of the mechanisms that drive RIP3-dependent necrosis and its role in different inflammatory diseases.read more
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Necroptosis in Hepatosteatotic Ischaemia-Reperfusion Injury
TL;DR: The effect of hepatic steatosis during liver transplantation as well as molecular mechanisms of necroptosis and its involvement during liver IR injury are focused on.
Journal ArticleDOI
Dynamin-Related Protein 1 Deficiency Leads to Receptor-Interacting Protein Kinase 3-Mediated Necroptotic Neurodegeneration.
TL;DR: Testing whether neurodegeneration involves necrotic cell death by generating Purkinje cell-specific Drp1-knockout mice that lack the receptor-interacting protein kinase 3 (Rip3), which regulates necroptosis found that the loss of Rip3 significantly delays the degeneration of Drp 1-KOPurkinje neurons.
Journal ArticleDOI
NLRP3 inflammasome in NMDA-induced retinal excitotoxicity.
Pavlina Tsoka,Paulo Rodolfo Tagliari Barbisan,Keiko Kataoka,Xiaohong Nancy Chen,Bo Tian,Peggy Bouzika,Joan W. Miller,Eleftherios I. Paschalis,Demetrios G. Vavvas +8 more
TL;DR: Results indicate that NMDA‐mediated retinal excitotoxicity induces immune cell recruitment and NLRP3 inflammasome activity even though inflammaome‐mediated neuroinflammation is not a leading contributing factor to cell death in this type of retinal injury.
Journal ArticleDOI
A novel function of RIP1 in postnatal development and immune homeostasis by protecting against RIP3-dependent necroptosis and FADD-mediated apoptosis
TL;DR: The data show that the postnatal developmental defect in rip1−/− mice is due in part to FADD-mediated apoptosis as well as RIP3-dependent necroptosis, and the function of RIP1 contributes to development of lpr diseases.
Journal ArticleDOI
Necrosis and necroptosis in germ cell depletion from mammalian ovary.
Govind R. Chaudhary,Pramod K. Yadav,Anil K. Yadav,Meenakshi Tiwari,Anumegha Gupta,Alka Sharma,Kankshi Sahu,Ashutosh N. Pandey,Ajai K. Pandey,Shail K. Chaube +9 more
TL;DR: Prevention of necrosis and necroptosis pathways using their specific inhibitors could enhance growth/differentiation factor‐9 expression, improve survivability as well as the meiotic competency of oocytes, and prevent decline of reproductive potential in several mammalian species and early onset of menopause in women.
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