RIP3: a molecular switch for necrosis and inflammation.
TLDR
The current understanding of the mechanisms that drive RIP3-dependent necrosis and its role in different inflammatory diseases is reviewed.Abstract:
The receptor-interacting protein kinase 3 (RIP3/RIPK3) has emerged as a critical regulator of programmed necrosis/ necroptosis, an inflammatory form of cell death with important functions in pathogen-induced and sterile inflammation. RIP3 activation is tightly regulated by phosphorylation, ubiquitination, and caspase-mediated cleavage. These post-translational modifications coordinately regulate the assembly of a macromolecular signaling complex termed the necrosome. Recently, several reports indicate that RIP3 can promote inflammation independent of its pronecrotic activity. Here, we review our current understanding of the mechanisms that drive RIP3-dependent necrosis and its role in different inflammatory diseases.read more
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Cell Death Pathways in Ischemic Stroke and Targeted Pharmacotherapy.
Aishika Datta,Deepaneeta Sarmah,Leela Mounica,Harpreet Kaur,Radhika Kesharwani,Geetesh Verma,Pabbala Veeresh,Vignesh Kotian,Kiran Kalia,Anupom Borah,Xin Wang,Kunjan R. Dave,Dileep R. Yavagal,Pallab Bhattacharya +13 more
TL;DR: Understanding the role of different cell death pathways is crucial to aid in the modern treatment of protecting apoptotic neurons and considers investigation on non-classical pathways that are tightly regulated, may or may not involve caspases, but non-apoptotic.
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Retinal damage induced by commercial light emitting diodes (LEDs).
Imene Jaadane,Pierre Boulenguez,Sabine Chahory,Samuel Carré,Michèle Savoldelli,Laurent Jonet,Francine Behar-Cohen,Christophe Martinsons,Alicia Torriglia +8 more
TL;DR: The role of blue light from LEDs in retinal damage was elucidated and LED light caused a state of suffering of the retina with oxidative damage and retinal injury.
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Inflammatory outcomes of apoptosis, necrosis and necroptosis.
TL;DR: The inflammatory implications of necrosis, necroptosis and apoptosis are discussed and some of the unresolved questions concerning how dead cells influence inflammatory responses are discussed.
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A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy.
Rekha Khandia,Maryam Dadar,Ashok Munjal,Kuldeep Dhama,Kumaragurubaran Karthik,Ruchi Tiwari,Mohd Iqbal Yatoo,Hafiz M.N. Iqbal,Karam Pal Singh,Sunil K. Joshi,Wanpen Chaicumpa +10 more
TL;DR: Various activators and suppressors of autophagy are described, which could be used to design novel intervention strategies against numerous diseases and develop therapeutic drugs to protect human and animal health.
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Necroptosis, in vivo detection in experimental disease models.
Sandrine Jouan-Lanhouet,Franck B. Riquet,Linde Duprez,Tom Vanden Berghe,Nozomi Takahashi,Peter Vandenabeele +5 more
TL;DR: This review will present the last methodological advances for in vivo necroptosis identification and discuss past and recent data to provide an update of the so-called "necroptotic-associated pathologies".
References
More filters
Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.
TL;DR: Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development, and participates in at least some types of therapeutically induced tumour regression.
Journal ArticleDOI
Cancer-related inflammation.
TL;DR: The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
Journal ArticleDOI
An endotoxin-induced serum factor that causes necrosis of tumors
TL;DR: It is proposed that TNF mediates endotoxin-induced tumor necrosis, and that it may be responsible for the suppression of transformed cells by activated macrophages.
Journal ArticleDOI
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
Michael C. Wei,Michael C. Wei,Wei-Xing Zong,Emily H. Cheng,Tullia Lindsten,Vily Panoutsakopoulou,Andrea J. Ross,Kevin A. Roth,Grant R. MacGregor,Craig B. Thompson,Stanley J. Korsmeyer +10 more
TL;DR: In this article, the authors found that doubly deficient cells are resistant to multiple apoptotic stimuli that act through disruption of mitochondrial function: staurosporine, ultraviolet radiation, growth factor deprivation, etoposide, and the endoplasmic reticulum stress stimuli thapsigargin and tunicamycin.