RIP3: a molecular switch for necrosis and inflammation.
TLDR
The current understanding of the mechanisms that drive RIP3-dependent necrosis and its role in different inflammatory diseases is reviewed.Abstract:
The receptor-interacting protein kinase 3 (RIP3/RIPK3) has emerged as a critical regulator of programmed necrosis/ necroptosis, an inflammatory form of cell death with important functions in pathogen-induced and sterile inflammation. RIP3 activation is tightly regulated by phosphorylation, ubiquitination, and caspase-mediated cleavage. These post-translational modifications coordinately regulate the assembly of a macromolecular signaling complex termed the necrosome. Recently, several reports indicate that RIP3 can promote inflammation independent of its pronecrotic activity. Here, we review our current understanding of the mechanisms that drive RIP3-dependent necrosis and its role in different inflammatory diseases.read more
Citations
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Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense
Xing Wang,Yun Li,Shan Liu,Xiaoliang Yu,Lin Li,Cuilin Shi,Wenhui He,Jun Li,Lei Xu,Zhilin Hu,Lu Yu,Zhongxu Yang,Qin Chen,Lin Ge,Zili Zhang,Biqi Zhou,Xuejun Jiang,She Chen,Sudan He +18 more
TL;DR: It is discovered that human herpes simplex virus 1 (HSV-1) infection triggers RIP3-dependent necrosis in host cells and is revealed a previously uncharacterized host antipathogen mechanism.
Journal ArticleDOI
The Necroptosis Adaptor RIPK3 Promotes Injury-Induced Cytokine Expression and Tissue Repair
Kenta Moriwaki,Sakthi Balaji,Thomas McQuade,Nidhi Malhotra,Joonsoo Kang,Francis Ka-Ming Chan +5 more
TL;DR: An unexpected function of RIPK3 is revealed in NF-κB activation, DC biology, innate inflammatory-cytokine expression, and injury-induced tissue repair.
Journal ArticleDOI
Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death.
TL;DR: It is shown that in human colon cancer tissues, the expression of the essential necroptosis adaptors receptor interacting protein kinase (RIPK)1 and RIPK3 is significantly decreased compared with adjacent normal colon tissues, and that traditional chemotherapeutic agents are not efficient inducers of necroPTosis.
Journal ArticleDOI
Quantification of apoptosis and necroptosis at the single cell level by a combination of Imaging Flow Cytometry with classical Annexin V/propidium iodide staining.
TL;DR: This method uses the combination of imaging flow cytometry with classical Annexin V/propidium iodide staining, which allows for the ascertainment of typical features of dying cells: exposure of the phospholipid phosphatidylserine and the loss of membrane integrity.
Journal ArticleDOI
An Inflammatory Perspective on Necroptosis
TL;DR: It is suggested that necroptosis might have anti-inflammatory effects in certain settings, through curbing excessive TNF- or TLR-induced inflammatory cytokine production.
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