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Risk genes in head and neck cancer: A systematic review and meta-analysis of last 5 years

Mabel Brunotto, +4 more
- 01 Mar 2014 - 
- Vol. 50, Iss: 3, pp 178-188
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TLDR
The aim of this work was to identify risk genes related to the development and progression of squamous cell carcinoma head and neck (SCCHN) and do a meta-analysis of available estimates, showing no significant association between different allelic variants of Arg72Pro rs1042522 and SCCHN risk.
About: 
This article is published in Oral Oncology.The article was published on 2014-03-01 and is currently open access. It has received 48 citations till now. The article focuses on the topics: Odds ratio.

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Unraveling the molecular genetics of head and neck cancer through genome-wide approaches.

Nadeem Riaz, +3 more
- 01 Sep 2014 - 
TL;DR: The expanding knowledge of the underlying molecular abnormalities in this once very poorly understood cancer should allow for increasingly rational clinical trial design and improved patient outcomes.
Journal ArticleDOI

Meta-analysis on the association between toothbrushing and head and neck cancer

Xian-Tao Zeng, +6 more
- 01 May 2015 - 
TL;DR: This meta-analysis found frequency of toothbrushing was significantly associated with HNC risk and it is suggested that the frequency be twice per day (morning and night).
Journal ArticleDOI

Folic Acid-Decorated Polyamidoamine Dendrimer Exhibits High Tumor Uptake and Sustained Highly Localized Retention in Solid Tumors: Its Utility for Local siRNA Delivery

Leyuan Xu, +2 more
- 15 Jul 2017 - 
TL;DR: It is demonstrated that localized delivery of FR-targeted PAMAM dendrimer G4 complexed with siVEGFA resulted in pronounced tumor suppression in an HN12 xenograft tumor model.
Journal ArticleDOI

The effect of photoinitiators on intracellular AKT signaling pathway in tissue engineering application.

Leyuan Xu, +3 more
- 20 Jan 2015 - 
TL;DR: The results show that the photoinitiators and their UV-exposed counterparts affect intracellular AKT signaling, which can be used in conjunction with cell viability for cytocompatibility assessment of photoInitiators.
Journal ArticleDOI

Polymorphisms and Plasma Levels of Tissue Inhibitor of Metalloproteinase-3: Impact on Genetic Susceptibility and Clinical Outcome of Oral Cancer.

Chun-Wen Su, +5 more
- 01 Nov 2015 - 
TL;DR: It is suggested that gene-environment interactions between the TIMP3 rs9862 polymorphisms and betel quid may alter oral cancer susceptibility and tumor growth in Taiwanese men.
References
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Journal ArticleDOI

Impacts of microRNA gene polymorphisms on the susceptibility of environmental factors leading to carcinogenesis in oral cancer.

Yin Hung Chu, +5 more
- 28 Jun 2012 - 
TL;DR: The results suggest that genetic polymorphism of miRNA499 is associated with oral carcinogenesis, and the interaction of the miRNAs genetic polymorphisms and environmental carcinogens is also related to an increased risk of oral cancer in Taiwanese.
Journal ArticleDOI

Effects of NFKB1 and NFKBIA Gene Polymorphisms on Susceptibility to Environmental Factors and the Clinicopathologic Development of Oral Cancer

Chiao Wen Lin, +7 more
- 11 Apr 2012 - 
TL;DR: The results suggest that NFKB1 −94 ATTG2, NFKBIA −826 T, and −881 G alleles are associated with oral carcinogenesis and the genetic polymorphism of NFK BIA −519 might be a predictive factor for the distal metastasis of OSCC in Taiwanese.
Journal Article

GSTM1, GSTT1 and CYP1A1 polymorphisms and risk of oral cancer: A case-control study in Jakarta, Indonesia

Rahmi Amtha, +7 more
- 01 Jan 2009 - 
TL;DR: Genetic polymorphisms of GSTM1, GSTT1 and CYP1A1 may not be risk factors for oral cancer in the Jakarta population and may not increase the risk of oral cancer.
Journal ArticleDOI

The microenvironments of multistage carcinogenesis

Ezio Laconi, +2 more
- 01 Oct 2008 - 
TL;DR: It is argued that a fundamental property of focal lesions as it relates to their precancerous nature lies in their altered growth pattern as compared to the tissue where they reside, which translates into the emergence of a unique tumor microenvironment inside these lesions, associated with altered blood vessels and/or blood supply.
Journal ArticleDOI

Effects of 10 Cigarette Smoke Condensates on Primary Human Airway Epithelial Cells by Comparative Gene and Cytokine Expression Studies

Gavin Pickett, +5 more
- 01 Mar 2010 - 
TL;DR: Differences in gene expression and cytokine production in primary normal human bronchial epithelial cells following treatment with cigarette smoke condensates prepared from five commercial and four research cigarettes lay the foundation for future investigations to analyze differences in the responses of in vivo systems to tobacco products marketed with claims of reduced exposure or reduced harm.
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Frequently Asked Questions (14)
Q1. What are the contributions mentioned in the paper "Risk genes in head and neck cancer: a systematic review and meta-analysis of last 5 years" ?

The case-control studies guidelines of the Scottish Intercollegiate Guidelines Network and MOOSE are followed. Two members of the team ( AB, AMZ ) evaluated complete articles independently and double-blinded, to establish their quality. The papers were encoded and delivered independently to each reviewer. 

It is known that the p53 suppressor tumor gene has a key role in stress cellular response, to preserve genome stability, and it is universally recognized as a human cancer marker when it is mutated. 

Overexpression of the DEC1 Protein InducesSenescence In Vitro and Is Related to Better Survival in Esophageal Squamous Cell Carcinoma. 

59 The AA genotype of the ADH1B R48H gene encodes an enzyme that is about 40 times more active than the enzyme encoded by AG and GG genotypes. 

The evaluation of diagnostic markers such as symptoms and genetic tests helps to increase the sensitivity or specificity of the determination of the presence/absence of malignancy. 

Authors such as Piva et al. 48 have observed inflammatory infiltrate in epithelial dysplasia with overexpression of NFKB and TNF-α, establishing a connection between the cancer and inflammation. 

61,62 Research by Su et al. 62 showed that allele G of CRYAB C-802G is correlated to breast cancer risk, and could be useful as a clinical marker for its early detection. 

the model proposed in this paper could fit models 1, 2, and 3 because it considers such epigenetic events as inflammation, mutational compounds such as tobacco and alcohol, and genomic stability and the cell cycle regulation process. 

The authors conducted a systematic review and meta-analysis of case-control studies from the MEDLINE, Scopus, Cochrane, and CancerLit databases between January 2007 and January 2013. 

3,29 Cancer is a complex pathology, and its incidence and survival index are closely related to social, cultural and socio-economic determinants of health. 

Pradhan S, Nagashri MN, Gopinath KS, Kumar A.Expression profiling of CYP1B1 in oral squamous cell carcinoma: counter intuitive down regulation in tumors. 

This gene encodes glutathioneStransferase Mu 1, which is critical to detoxification and the removal of electrophilic carcinogens. 

The identification of a predictive model of risk polymorphisms could help in early diagnosis, and in understanding disease recurrence and/or progression in the subset of patients. 

A search was made of combined electronic databases, and the bibliographies of all selected papers were searched to identify grey literature.