Unraveling the molecular genetics of head and neck cancer through genome-wide approaches.
TLDR
The expanding knowledge of the underlying molecular abnormalities in this once very poorly understood cancer should allow for increasingly rational clinical trial design and improved patient outcomes.Abstract:
The past decade has seen an unprecedented increase in our understanding of the biology and etiology of head and neck squamous cell carcinomas (HNSCC). Genome-wide sequencing projects have identified a number of recurrently mutated genes, including unexpected alterations in the NOTCH pathway and chromatin related genes. Gene-expression profiling has identified 4 distinct genetic subtypes which show some parallels to lung squamous cell carcinoma biology. The identification of the human papilloma virus as one causative agent in a subset of oropharyngeal cancers and their association with a favorable prognosis has opened up avenues for new therapeutic strategies. The expanding knowledge of the underlying molecular abnormalities in this once very poorly understood cancer should allow for increasingly rational clinical trial design and improved patient outcomes.read more
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Journal Article
The Mutational Landscape of Head and Neck Squamous Cell Carcinoma
Nicolas Stransky,Ann Marie Egloff,Aaron D. Tward,Aleksandar Kostic,Kristian Cibulskis,Andrey Sivachenko,Gregory Kryukov,Michael S. Lawrence,Carrie Sougnez,Aaron McKenna,Erica Shefler,Alex H. Ramos,Petar Stojanov,Scott L. Carter,Douglas Voet,Maria L. Cortes,Daniel Auclair,Michael F. Berger,Gordon Saksena,Candace Guiducci,Robert C. Onofrio,Melissa Parkin,Marjorie Romkes,Joel L. Weissfeld,Raja R. Seethala,Lin Wang,Claudia Rangel-Escareño,Juan Carlos Fernández-López,Alfredo Hidalgo-Miranda,Jorge Melendez-Zajgla,Wendy Winckler,Kristin Ardlie,Stacey Gabriel,Matthew Meyerson,Eric S. Lander,Gad Getz,Todd R. Golub,Levi A. Garraway,Jennifer R. Grandis +38 more
TL;DR: The results indicate the ability of large-scale sequencing to reveal fundamental tumorigenic mechanisms and suggest the development of targeted therapies for head and neck cancer may be hindered by complex mutational profiles.
Journal ArticleDOI
Frameshift events predict anti–PD-1/L1 response in head and neck cancer
Glenn J. Hanna,Patrick H. Lizotte,Megan E. Cavanaugh,Frank C. Kuo,Priyanka Shivdasani,Alexander Frieden,Nicole G. Chau,Jonathan D. Schoenfeld,Jochen H. Lorch,Ravindra Uppaluri,Laura E. MacConaill,Laura E. MacConaill,Robert I. Haddad +12 more
TL;DR: Somatic frameshift events in tumor suppressor genes and higher TMB among virus-negative SCCHN tumors predict anti-PD-1/L1 response.
Journal ArticleDOI
Tobacco-related carcinogenesis in head and neck cancer
TL;DR: Intense work pertaining to tobacco product constituents, tobacco use, and tobacco regulation has resulted in decreased use in some parts of the world, but much work remains as tobacco continues to impart significant harm and contribute to HNSCC development worldwide.
Journal ArticleDOI
Patterns of Treatment Failure and Postrecurrence Outcomes Among Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma After Chemoradiotherapy Using Modern Radiation Techniques.
Jonathan E. Leeman,Jin-Gao Li,Xin Pei,Praveen Venigalla,Zachary S. Zumsteg,Evangelia Katsoulakis,Eitan Lupovitch,Sean McBride,Chiaojung J. Tsai,Jay O. Boyle,Benjamin R. Roman,Luc G. T. Morris,Lara Dunn,Eric J. Sherman,Nancy Y. Lee,Nadeem Riaz +15 more
TL;DR: Overall survival after recurrence of HNSCC is influenced by the H NSCC subsite and human papillomavirus or p16 status, as well surgical and systemic interventions.
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Anticancer Activities of Protopanaxadiol- and Protopanaxatriol-Type Ginsenosides and Their Metabolites
TL;DR: This review aims at providing an overview of PTS and PDS, as well as their metabolites, regarding their different anticancer effects with the proposal that these compounds might be potent additions to the current chemotherapeutic strategy against cancer.
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TL;DR: It is shown that hypermutation localized to small genomic regions, ‘kataegis’, is found in many cancer types, and this results reveal the diversity of mutational processes underlying the development of cancer.
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