Risk of COVID-19-related death among patients with chronic obstructive pulmonary disease or asthma prescribed inhaled corticosteroids: an observational cohort study using the OpenSAFELY platform.
Anna Schultze,Alex J Walker,Brian MacKenna,Caroline E Morton,Krishnan Bhaskaran,Jeremy P Brown,Christopher T Rentsch,Elizabeth Williamson,Henry Drysdale,Richard Croker,Seb Bacon,William J Hulme,Christopher M. Bates,Helen J Curtis,Amir Mehrkar,David M. Evans,Peter Inglesby,Jonathan Cockburn,Helen Mcdonald,Laurie A. Tomlinson,Rohini Mathur,Kevin Wing,Angel Y S Wong,Harriet Forbes,John Parry,Frank Hester,Sam Harper,Stephen J. W. Evans,Jennifer K Quint,Liam Smeeth,Ian J. Douglas,Ben Goldacre +31 more
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TLDR
The results do not support a major role for regular ICS use in protecting against COVID-19-related death among people with asthma or COPD, and the apparent harmful association observed can be plausibly explained by unmeasured confounding due to disease severity.Citations
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Can we predict the severe course of COVID-19 - a systematic review and meta-analysis of indicators of clinical outcome?
Stephan Katzenschlager,Alexandra J. Zimmer,Claudius Gottschalk,Jürgen Grafeneder,Stephani Schmitz,Sara Kraker,Marlene Ganslmeier,Amelie Muth,Alexander Seitel,Lena Maier-Hein,Andrea Benedetti,Jan Larmann,Markus A. Weigand,Sean McGrath,Claudia M. Denkinger +14 more
TL;DR: In this article, a systematic review and meta-analysis was conducted to assess demographic, laboratory and clinical indicators as predictors for severe courses of COVID-19 in over 40 million people globally with variable clinical outcomes.
Journal ArticleDOI
Inhaled Corticosteroids and COVID-19 Risk and Mortality: A Nationwide Cohort Study
Jae Chol Choi,Sun-Young Jung,Una A. Yoon,Seung-Hun You,Myo-Song Kim,Moon Seong Baek,Jae-Woo Jung,Won-Young Kim +7 more
TL;DR: Inhaled corticosteroids (ICS) could increase both the risk of coronavirus disease 2019 (COVID-19) and experiencing poor outcomes and clinical outcomes among patients with COPD or asthma, according to a nested case-control study.
Journal ArticleDOI
Asthma and COVID-19: do we finally have answers?
Katrien Eger,Elisabeth H. Bel +1 more
TL;DR: In this article, large-scale studies confirm previous findings about a slightly increased incidence of COVID-19, but not of severe COVID19, in asthma patients, but no definitive conclusions can be drawn since many bias factors have not been taken into account.
Journal ArticleDOI
Impact of Allergic Rhinitis and Asthma on COVID-19 Infection, Hospitalization, and Mortality
TL;DR: In this article , the role of AR and/or asthma in corona virus disease 2019 (COVID-19) infection, severity, and mortality was investigated, and the impact of long-term AR and or asthma medications on the risk of hospitalization and mortality were further analyzed.
Journal ArticleDOI
Impact of Allergic Rhinitis and Asthma on COVID-19 Infection, Hospitalization, and Mortality.
Hanna Wellauer,Jianjun Ren,Wendu Pang,Robert Blake,Aušra Teleišė,Yaxin Luo,Danni Cheng,Ke Qiu,Yufang Rao,Yongbo Zheng,Yijun Dong,Jiajia Peng,Yao Hu,Zhiye Ying,Haopeng Yu,Xiaoxi Zeng,Zhiyong Zong,Geoffrey Liu,Deyun Wang,Gang Wang,Wei Zhang,Wei Xu,Yu Zhao +22 more
TL;DR: In this paper, the authors investigated the role of AR and/or asthma in corona virus disease 2019 infection, severity, and mortality, and assessed whether long-term AR and or asthma medications affected the outcomes of COVID-19.
References
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Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more
TL;DR: During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area.
Safiya Richardson,Safiya Richardson,Jamie S. Hirsch,Jamie S. Hirsch,Mangala Narasimhan,James M. Crawford,Thomas McGinn,Thomas McGinn,Karina W. Davidson,Karina W. Davidson,Douglas P. Barnaby,Douglas P. Barnaby,Lance B Becker,John Chelico,John Chelico,Stuart L. Cohen,Stuart L. Cohen,Jennifer Cookingham,Kevin Coppa,Michael A Diefenbach,Andrew J. Dominello,Joan Duer-Hefele,Louise Falzon,Jordan Gitlin,Negin Hajizadeh,Negin Hajizadeh,Tiffany G. Harvin,David Hirschwerk,Eun Ji Kim,Eun Ji Kim,Zachary Kozel,Lyndonna Marrast,Lyndonna Marrast,Jazmin N. Mogavero,Gabrielle A. Osorio,Michael Qiu,Theodoros P. Zanos +36 more
TL;DR: This case series provides characteristics and early outcomes of sequentially hospitalized patients with confirmed COVID-19 in the New York City area and assesses outcomes during hospitalization, such as invasive mechanical ventilation, kidney replacement therapy, and death.
Journal ArticleDOI
Factors associated with COVID-19-related death using OpenSAFELY.
Elizabeth A. Williamson,Alex J Walker,Krishnan Bhaskaran,Seb Bacon,Chris Bates,Caroline E Morton,Helen J Curtis,Amir Mehrkar,David M. Evans,Peter Inglesby,Jonathan Cockburn,Helen Mcdonald,Brian MacKenna,Laurie A. Tomlinson,Ian J. Douglas,Christopher T Rentsch,Rohini Mathur,Angel Y S Wong,Richard Grieve,David G. Harrison,Harriet Forbes,Anna Schultze,Richard Croker,John Parry,Frank Hester,Sam Harper,Rafael Perera,Stephen J. W. Evans,Liam Smeeth,Ben Goldacre +29 more
TL;DR: A range of clinical factors associated with COVID-19-related death is quantified in one of the largest cohort studies on this topic so far and includes people of white ethnicity, Black and South Asian people were at higher risk, even after adjustment for other factors.
Journal ArticleDOI
Global strategy on diet, physical activity and health
TL;DR: An expert report aiming to design strategies in promoting healthy diets and physical activity behaviours was published a year ago by the United Nations Food and Agriculture Organization.
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Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area.
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