Journal ArticleDOI
Role of interleukin 8 in depression and other psychiatric disorders.
TLDR
In this review, studies focusing on the role of IL-8 in psychiatric diseases such as major depression, bipolar disorder, schizophrenia, sleep disorder, autism spectrum disorder, anxiety disorders and dementia are highlighted.Abstract:
Low grade neuroinflammation has been suggested as one of the underlying mechanisms of many psychiatric diseases as well as cognitive disorders. Interleukin 8 (IL-8), a proinflammatory cytokine produced by many cell types including macrophage and microglia, mainly functions as a neutrophil chemoattractant in the bloodstream. IL-8 is also found in the brain, where it is released from microglia in response to proinflammatory stimuli. In this review, we highlight studies focusing on the role of IL-8 in psychiatric diseases such as major depression, bipolar disorder, schizophrenia, sleep disorder, autism spectrum disorder, anxiety disorders and dementia. Increased peripheral IL-8 levels have been reported in these diseases, particularly in schizophrenic disorder, bipolar disorder, obstructive sleep apnea and autism spectrum disorder. The literature on IL-8 and major depression is inconsistent. IL-8 has been found to be a factor associated with schizophrenic prognosis and therapeutic response, and may affect a wide range of symptomatology. Considering that the exact role of immune alterations is still under research, the success of immune-based therapies in psychiatric diseases is limited for the time being.read more
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Stress-Associated Molecular and Cellular Hippocampal Mechanisms Common for Epilepsy and Comorbid Depressive Disorders.
TL;DR: In this paper, a review discusses molecular and cellular mechanisms common to the temporal lobe epileptogenesis/epilepsychepsy and depressive disorders, including the dysfunction of glucocorticoid receptors, neurotransmitters, and neurotrophic factors, development of neuroinflammation, leading to neurodegeneration and loss of hippocampal neurons.
Journal ArticleDOI
Delirium due to hip fracture is associated with activated immune-inflammatory pathways and a reduction in negative immunoregulatory mechanisms
TL;DR: In this paper , the authors found that post-hip surgery delirium is associated with activation of the immune-inflammatory response system (IRS) as indicated by activation of M1, T helper (Th)1, and Th17 profiles, and/or by reduced activities of the compensatory immunoregulatory system (CIRS), including Th2 and T regulatory profiles.
Journal ArticleDOI
Selected Biomarkers of Depression: What Are the Effects of Cytokines and Inflammation?
TL;DR: A review of the most recent data on cytokines as markers of depression concerning their roles in its pathogenesis, their possible use in diagnosis and management, their different levels in bodily fluids, and their similarities in animal studies is presented in this article .
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Fibromyalgia and Depression: A Literature Review of Their Shared Aspects
TL;DR:
Journal Article
The impact of genetic research on our understanding of normal cognitive ageing: 1995 to 2009
TL;DR: A comprehensive review of the studies performed on cognitively healthy individuals, from the first study conducted in 1995 to present, can be found in this paper, where the strong and weak methodologies for future study design are identified and suggestions for future design will be presented.
References
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Journal ArticleDOI
Lipid peroxides, superoxide dismutase and circulating IL-8 and GCP-2 in patients with severe obstructive sleep apnea: a pilot study.
TL;DR: The hypothesis that OSA is linked to increased oxidative stress and decreased antioxidant defense and the serum levels of neutrophil chemokines, IL-8, and granulocyte chemotactic protein-2 suggest that systemic inflammation characterizes OSA patients.
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Altered peripheral blood compounds in drug-naïve first-episode patients with either schizophrenia or major depressive disorder: a meta-analysis.
Nuray Çakici,Arjen L. Sutterland,Brenda W.J.H. Penninx,Virgil A. S. H. Dalm,Lieuwe de Haan,Nico J.M. van Beveren +5 more
TL;DR: The findings support efforts for further research into transdiagnostic preventive strategies and augmentation therapy for those with immune or metabolic dysfunctions in schizophrenia and major depressive disorder.
Journal Article
Investigation of serum cytokine levels and cytokine production in whole blood cultures of paranoid schizophrenic patients.
Teresa Kamińska,Alicja Wysocka,Halina Marmurowska-Michałowska,Halina Dubas-Slemp,Martyna Kandefer-Szerszeń +4 more
TL;DR: Increased serum levels of some cytokines such as IL-6, IL-8 and IFN-gamma indicate an activation of the inflammatory response in schizophrenia, while the in vitro assay indicates significant changes in the Th1 (decreased production of 1L-2 and IF ngamma) and Th2 cell system responses.
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Inflammation and kynurenine pathway dysregulation in post-partum women with severe and suicidal depression
Eric D. Achtyes,Sarah A. Keaton,LeAnn Smart,Amanda R. Burmeister,Patrick Heilman,Stanislaw Krzyzanowski,Madhavi Nagalla,Gilles J. Guillemin,Martha L. Escobar Galvis,Chai K. Lim,Maria Muzik,Teodor T. Postolache,Richard Leach,Lena Brundin,Lena Brundin +14 more
TL;DR: It is proposed that inflammatory cytokines and the kynurenine pathway are potential treatment targets in PPD, opening up the possibility of novel therapeutic strategies targeting the peripartum.
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Neurotransmitter characteristics of brain grafts: striatal and septal tissues form the same laminated input to the hippocampus.
Ellen R. Lewis,Carl W. Cotman +1 more
TL;DR: Findings suggest that cues underlying the development of specific connections between native (and implanted) septal efferents and hippocampal target neurons may be recognized by ingrowing acetylcholinesterase-reactive fibers from striatal implants.