Journal ArticleDOI
Role of interleukin 8 in depression and other psychiatric disorders.
TLDR
In this review, studies focusing on the role of IL-8 in psychiatric diseases such as major depression, bipolar disorder, schizophrenia, sleep disorder, autism spectrum disorder, anxiety disorders and dementia are highlighted.Abstract:
Low grade neuroinflammation has been suggested as one of the underlying mechanisms of many psychiatric diseases as well as cognitive disorders. Interleukin 8 (IL-8), a proinflammatory cytokine produced by many cell types including macrophage and microglia, mainly functions as a neutrophil chemoattractant in the bloodstream. IL-8 is also found in the brain, where it is released from microglia in response to proinflammatory stimuli. In this review, we highlight studies focusing on the role of IL-8 in psychiatric diseases such as major depression, bipolar disorder, schizophrenia, sleep disorder, autism spectrum disorder, anxiety disorders and dementia. Increased peripheral IL-8 levels have been reported in these diseases, particularly in schizophrenic disorder, bipolar disorder, obstructive sleep apnea and autism spectrum disorder. The literature on IL-8 and major depression is inconsistent. IL-8 has been found to be a factor associated with schizophrenic prognosis and therapeutic response, and may affect a wide range of symptomatology. Considering that the exact role of immune alterations is still under research, the success of immune-based therapies in psychiatric diseases is limited for the time being.read more
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Stress-Associated Molecular and Cellular Hippocampal Mechanisms Common for Epilepsy and Comorbid Depressive Disorders.
TL;DR: In this paper, a review discusses molecular and cellular mechanisms common to the temporal lobe epileptogenesis/epilepsychepsy and depressive disorders, including the dysfunction of glucocorticoid receptors, neurotransmitters, and neurotrophic factors, development of neuroinflammation, leading to neurodegeneration and loss of hippocampal neurons.
Journal ArticleDOI
Delirium due to hip fracture is associated with activated immune-inflammatory pathways and a reduction in negative immunoregulatory mechanisms
TL;DR: In this paper , the authors found that post-hip surgery delirium is associated with activation of the immune-inflammatory response system (IRS) as indicated by activation of M1, T helper (Th)1, and Th17 profiles, and/or by reduced activities of the compensatory immunoregulatory system (CIRS), including Th2 and T regulatory profiles.
Journal ArticleDOI
Selected Biomarkers of Depression: What Are the Effects of Cytokines and Inflammation?
TL;DR: A review of the most recent data on cytokines as markers of depression concerning their roles in its pathogenesis, their possible use in diagnosis and management, their different levels in bodily fluids, and their similarities in animal studies is presented in this article .
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Fibromyalgia and Depression: A Literature Review of Their Shared Aspects
TL;DR:
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The impact of genetic research on our understanding of normal cognitive ageing: 1995 to 2009
TL;DR: A comprehensive review of the studies performed on cognitively healthy individuals, from the first study conducted in 1995 to present, can be found in this paper, where the strong and weak methodologies for future study design are identified and suggestions for future design will be presented.
References
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Journal ArticleDOI
Abnormalities in chemokine levels in schizophrenia and their clinical correlates.
Suzi Hong,Ellen E. Lee,Averria Sirkin Martin,Benchawanna Soontornniyomkij,Virawudh Soontornniyomkij,Cristian L. Achim,Chase Reuter,Michael R. Irwin,Lisa T. Eyler,Lisa T. Eyler,Dilip V. Jeste +10 more
TL;DR: Levels of chemokines with neuroimmune regulatory effects were higher in individuals with schizophrenia, particularly in older and chronic patients, and Treatments aimed at normalizing chemokine levels might improve mental and physical health among schizophrenia patients as they age.
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Sex Differences in the Peripheral Immune System in Patients with Depression
TL;DR: The findings indicate a sex-specific relationship between inflammation and depression, which may be important in identifying potential psychopathology and suggesting novel immunomodulatory treatments for depressed females.
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Cytokines in cerebrospinal fluid of patients with schizophrenia spectrum disorders: New data and an updated meta-analysis.
Juan A. Gallego,Emily A. Blanco,Sehba Husain-Krautter,E. Madeline Fagen,Paula Moreno-Merino,Juan A. del Ojo-Jiménez,Anthony O. Ahmed,Thomas L. Rothstein,Todd Lencz,Anil K. Malhotra +9 more
TL;DR: A meta-analysis of the available data on cytokine levels in the CSF of patients with a schizophrenia spectrum disorder (SSD) diagnosis and healthy controls showed statistically significant increases in interleukin-6 (IL-6) and IL-8 in patients compared to healthy volunteers.
Journal ArticleDOI
Low IL-8 is associated with anxiety in suicidal patients: genetic variation and decreased protein levels
Shorena Janelidze,Petra Suchankova,Agneta Ekman,Sophie Erhardt,Carl M. Sellgren,Martin Samuelsson,Åsa Westrin,Lennart Minthon,Oskar Hansson,Lil Träskman-Bendz,Lena Brundin,Lena Brundin +11 more
TL;DR: Interleukin‐8 (IL‐8) is a chemokine that in addition to its function in the immune system also exert neuroprotective properties, and its involvement in neuropsychiatric conditions is incompletely known.
Journal ArticleDOI
Inhibition of long-term potentiation by interleukin-8: implications for human immunodeficiency virus-1-associated dementia
Huangui Xiong,Jeffery Boyle,Matthew Winkelbauer,Santhi Gorantla,Jialin C. Zheng,Anuja Ghorpade,Yuri Persidsky,Kimberly A. Carlson,Howard E. Gendelman +8 more
TL;DR: The induction of IL‐8 in HAD, its inhibition of LTP, and the expression of its receptor, CXCR2, in the hippocampus all suggest that it plays a role in the cognitive dysfunction associated with HAD.