Journal ArticleDOI
Role of interleukin 8 in depression and other psychiatric disorders.
TLDR
In this review, studies focusing on the role of IL-8 in psychiatric diseases such as major depression, bipolar disorder, schizophrenia, sleep disorder, autism spectrum disorder, anxiety disorders and dementia are highlighted.Abstract:
Low grade neuroinflammation has been suggested as one of the underlying mechanisms of many psychiatric diseases as well as cognitive disorders. Interleukin 8 (IL-8), a proinflammatory cytokine produced by many cell types including macrophage and microglia, mainly functions as a neutrophil chemoattractant in the bloodstream. IL-8 is also found in the brain, where it is released from microglia in response to proinflammatory stimuli. In this review, we highlight studies focusing on the role of IL-8 in psychiatric diseases such as major depression, bipolar disorder, schizophrenia, sleep disorder, autism spectrum disorder, anxiety disorders and dementia. Increased peripheral IL-8 levels have been reported in these diseases, particularly in schizophrenic disorder, bipolar disorder, obstructive sleep apnea and autism spectrum disorder. The literature on IL-8 and major depression is inconsistent. IL-8 has been found to be a factor associated with schizophrenic prognosis and therapeutic response, and may affect a wide range of symptomatology. Considering that the exact role of immune alterations is still under research, the success of immune-based therapies in psychiatric diseases is limited for the time being.read more
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Plasma Levels of the Cytokines B Cell-Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL) in Schizophrenia, Bipolar, and Major Depressive Disorder: A Cross Sectional, Multisite Study.
John Abel Engh,Thor Ueland,Thor Ueland,Thor Ueland,Ingrid Agartz,Ingrid Agartz,Dimitrios Andreou,Dimitrios Andreou,Pål Aukrust,Pål Aukrust,Birgitte Boye,Birgitte Boye,Erlend Bøen,Ole Kristian Drange,Torbjørn Elvsåshagen,Sigrun Hope,Margrethe Collier Høegh,Inge Joa,Inge Joa,Erik Johnsen,Erik Johnsen,Rune A. Kroken,Rune A. Kroken,Trine Vik Lagerberg,Tove Lekva,Ulrik Fredrik Malt,Ingrid Melle,Ingrid Melle,Gunnar Morken,Terje Nærland,Terje Nærland,Vidar M. Steen,Vidar M. Steen,Kirsten Wedervang-Resell,Melissa Auten Weibell,Melissa Auten Weibell,Lars T. Westlye,Lars T. Westlye,Srdjan Djurovic,Srdjan Djurovic,Nils Eiel Steen,Nils Eiel Steen,Ole A. Andreassen,Ole A. Andreassen +43 more
TL;DR: In this article, the authors investigated if plasma levels of BAFF and APRIL differed between patients with SCZ, BIP, and major depressive disorder (MDD), and tested for associations with psychotic symptom load, controlling for sociodemographic status, antipsychotic and other psychotropic medication, smoking, body mass index, and high sensitivity CRP.
Journal ArticleDOI
Associations of Dietary Exposure to Organochlorine Pesticides from Plant-Origin Foods with Lipid Metabolism and Inflammation in Women: A Multiple Follow-up Study in North China
Xuepeng Wang,Miaomiao Gao,Yixi Tan,Qi Li,Junxi Chen,Changxin Lan,Bahabieke Jiangtulu,Bin Wang,Guofeng Shen,Yanxin Yu,Zhiwen Li +10 more
TL;DR: Dietary intake of some individual DDT, DDE- dieldrin-, and endosulfan-class chemicals from plant-origin foods may interfere with lipid metabolism and inflammation responses.
Journal ArticleDOI
IL-6 and IL-8 are likely associated with psychological status in treatment naïve general population.
Xiao Liu,Jingjing Huang,Yuan Jiang,Zhengyu Cao,Mao-Xiong Wu,Runlu Sun,Zhi-Teng Chen,Peng Yu,Jianyong Ma,Yangxin Chen,Yuling Zhang,Jingfeng Wang +11 more
TL;DR: In this paper, the authors investigated the inflammatory biomarker profiles of psychological treatment-naive individuals and found that a higher CESD total score was correlated with higher CRP (p = 0.009), IL-6 (p=0.013), and IL-8 (p < 0.05) levels.
Journal ArticleDOI
Serum inflammatory markers and their associations with white matter integrity of the corpus callosum in schizophrenia patients and healthy controls
Anna Michalczyk,Ernest Tyburski,Piotr Podwalski,Katarzyna Waszczuk,Krzysztof Rudkowski,Jolanta Kucharska-Mazur,Monika Mak,Katarzyna Rek-Owodziń,Piotr Plichta,Maksymilian Bielecki,Wojciech Andrusewicz,Elżbieta Cecerska-Heryć,Agnieszka Samochowiec,Błażej Misiak,Leszek Sagan,Jerzy Samochowiec +15 more
TL;DR: In this article , the authors investigated whether the integrity of the corpus callosum is correlated with levels of peripheral inflammatory markers, including interleukin-6 (IL-6), IL-8, IL-10, tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), and C-reactive protein (CRP).
Journal ArticleDOI
RNA regulation of inflammatory responses in glia and its potential as a therapeutic target in central nervous system disorders
Abhishek Guha,Mohammed Amir Husain,Ying-kui Si,L. Burt Nabors,Natalia Filippova,Grace Promer,Reed Smith,Peter H. King +7 more
TL;DR: The concept of adenine and uridine-rich element (ARE) mediated RNA regulation and its impact on glial-driven neuroinflammatory diseases has been discussed in this paper , where strategies to target this novel level of gene regulation for therapeutic effect and review exciting preliminary studies that underscore its potential for treating neurological disorders.
References
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A Meta-Analysis of Cytokines in Major Depression
Yekta Dowlati,Nathan Herrmann,Nathan Herrmann,Walter Swardfager,Walter Swardfager,Helena Liu,Lauren Sham,Elyse K. Reim,Krista L. Lanctôt,Krista L. Lanctôt +9 more
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TL;DR: The multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress are described.
Journal ArticleDOI
Cytokine-induced sickness behaviour: mechanisms and implications.
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Journal ArticleDOI
A Meta-Analysis of Cytokines in Alzheimer's Disease
Walter Swardfager,Krista L. Lanctôt,Krista L. Lanctôt,Lana S. Rothenburg,Amy P. Wong,Amy P. Wong,Jaclyn Cappell,Nathan Herrmann,Nathan Herrmann +8 more
TL;DR: The results strengthen the clinical evidence that AD is accompanied by an inflammatory response, particularly higher peripheral concentrations of IL-6, TNF-α, IL-1β, TGF-β,IL-12 and IL-18 and higher CSF concentrations of T GF-β.