Journal ArticleDOI
Role of microRNA 21 in diabetes and associated/related diseases.
TLDR
The present mini review highlights the recent investigations related to the importance of miR-21 in different types of DM based on the up-to-date reports.Citations
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Tools for Sequence-Based miRNA Target Prediction: What to Choose?
TL;DR: The biological fundamentals of these prediction tools are described, the main sequence-based algorithms are characterized, and some insights into their uses by biologists are offered.
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TransmiR v2.0: an updated transcription factor-microRNA regulation database.
TL;DR: The updated TransmiR v2.0 database for more comprehensive information about transcription factor (TF)-miRNA regulations is described, with improved data coverage and webserver functionalities, to be a useful resource for investigating the regulation of miRNAs.
Journal ArticleDOI
Regulatory Roles of MicroRNAs in Diabetes.
Juan Feng,Xing Wanli,Lan Xie +2 more
TL;DR: The investigations of the regulatory roles of important miRNAs in diabetes, as well as the potential of circulating mi RNAs as diagnostic markers for diabetes mellitus are summarized.
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Circulating MicroRNAs as Potential Biomarkers of Exercise Response.
TL;DR: This overview aims to summarize the current knowledge related to the response of blood c-miRNAs profiles to different modes of exercise and to highlight their potential application as a novel class of biomarkers of physical performance capacity and training adaptation.
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Milk’s Role as an Epigenetic Regulator in Health and Disease
Bodo C. Melnik,Gerd Schmitz +1 more
TL;DR: It is hypothesize that the same miRNAs that epigenetically increase lactation, upregulate gene expression of the milk recipient via milk-derived mi RNAs, that are identical to their human analogs.
References
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Global and societal implications of the diabetes epidemic
TL;DR: The prevention of diabetes and control of its micro- and macrovascular complications will require an integrated, international approach if the authors are to see significant reduction in the huge premature morbidity and mortality it causes.
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MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells.
TL;DR: It is shown that the highly malignant human brain tumor, glioblastoma, strongly over-expresses a specific miRNA, miR-21, which may contribute to the malignant phenotype by blocking expression of critical apoptosis-related genes.
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miR-21-mediated tumor growth
TL;DR: The results suggest that miR-21 functions as an oncogene and modulates tumorigenesis through regulation of genes such as bcl-2 and thus, it may serve as a novel therapeutic target.
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MicroRNA-373 induces expression of genes with complementary promoter sequences
TL;DR: Findings reveal a new mode by which miRNAs may regulate gene expression, and identify a miRNA that targets promoter sequences and induces gene expression.
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Type 2 Diabetes Mellitus: A Review of Current Trends
TL;DR: Type 2 diabetes mellitus is a chronic metabolic disorder in which prevalence has been increasing steadily all over the world and the number of people affected expected to double in the next decade due to increase in ageing population, thereby adding to the already existing burden for healthcare providers, especially in poorly developed countries.