Role of stem cells in cardiovascular biology
TLDR
The controversy as to whether the adult heart possesses an intrinsic growth reserve is addressed, and several theories have been proposed and are presented in this review article.About:
This article is published in Journal of Thrombosis and Haemostasis.The article was published on 2011-07-22 and is currently open access. It has received 21 citations till now. The article focuses on the topics: Stem cell & Progenitor cell.read more
Citations
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Mammalian heart renewal by pre-existing cardiomyocytes
Samuel E. Senyo,Matthew L. Steinhauser,Christie L Pizzimenti,Vicky K. Yang,Lei Cai,Mei Wang,Ting-Di Wu,Ting-Di Wu,Jean-Luc Guerquin-Kern,Jean-Luc Guerquin-Kern,Claude Lechene,Richard T. Lee,Richard T. Lee +12 more
TL;DR: It is found that cell cycle activity during normal ageing and after injury led to polyploidy and multinucleation, but also to new diploid, mononucleate cardiomyocytes.
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P2959 Senescence and death of primitive cells and myocytes leads to premature cardiac ageing and heart failure
TL;DR: In this article, the authors compared endomyocardial biopsies from 19 old patients with a dilated myopathy with specimens from 7 individuals of similar age and normal ventricular function, and found that cell death markedly increased and occurred only in cells expressing p16INK4a that had significant telomeric shortening.
Journal Article
Ventricular Myocytes Are Not Terminally Differentiated in the Adult Mammalian Heart
PieroAnversa,JanKajstura +1 more
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Cell therapy for human ischemic heart diseases: Critical review and summary of the clinical experiences
Noemi Pavo,Silvia Charwat,Noemi Nyolczas,Andras Jakab,Zsolt Murlasits,Jutta Bergler-Klein,Mariam Nikfardjam,Imre Benedek,Teodora Benedek,Imre J. Pavo,Bernard J. Gersh,Kurt Huber,Gerald Maurer,Mariann Gyöngyösi +13 more
TL;DR: Meta-analyses of human cardiac cell-based studies have tried to gather sufficient number of subjects to present a statistical compelling statement, reporting modest success with a mean increase in left ventricular global ejection fraction.
Journal Article
C-kit-positive cardiac stem cells and myocardial regeneration.
TL;DR: Two distinct subpopulations of endogenous cardiac stem cells (CSCs) are identified in the adult heart; myogenic and vasculogenic CSCs, which are characterized by the presence of c-kit receptor, reside in the myocyte niche surrounded by matured cardiomyocytes, whereas vasculogens, which express c-Kit as well as KDR, are stored in the vascular niche found in the vessel wall.
References
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Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
Massimo Dominici,K. Le Blanc,Ingo Mueller,I. Slaper-Cortenbach,Frank C. Marini,Diane S. Krause,Robert J. Deans,Armand Keating,Darwin J. Prockop,Edwin M. Horwitz +9 more
TL;DR: The Mesenchymal and Tissue Stem Cell Committee of the International Society for Cellular Therapy proposes minimal criteria to define human MSC, believing this minimal set of standard criteria will foster a more uniform characterization of MSC and facilitate the exchange of data among investigators.
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Neurogenesis in the adult human hippocampus
Peter S. Eriksson,Ekaterina Perfilieva,Thomas Björk-Eriksson,Ann Marie Alborn,Claes Nordborg,Daniel A. Peterson,Fred H. Gage +6 more
TL;DR: It is demonstrated that new neurons, as defined by these markers, are generated from dividing progenitor cells in the dentate gyrus of adult humans, indicating that the human hippocampus retains its ability to generate neurons throughout life.
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Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration
Antonio Paolo Beltrami,Laura Barlucchi,Daniele Torella,Mathue Baker,Federica Limana,Stefano Chimenti,Hideko Kasahara,Marcello Rota,Ezio Musso,Konrad Urbanek,Annarosa Leri,Jan Kajstura,Bernardo Nadal-Ginard,Piero Anversa +13 more
TL;DR: The existence of Lin(-) c-kit(POS) cells with the properties of cardiac stem cells, which are self-renewing, clonogenic, and multipotent, giving rise to myocytes, smooth muscle, and endothelial cells are reported.
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Evidence for cardiomyocyte renewal in humans
Olaf Bergmann,Ratan D. Bhardwaj,Samuel Bernard,Sofia Zdunek,Fanie Barnabé-Heider,Stuart Walsh,Joel Zupicich,Kanar Alkass,Bruce A. Buchholz,Henrik Druid,Stefan Jovinge,Jonas Frisén +11 more
TL;DR: The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.
Journal Article
The relationship between the spleen colony-forming cell and the haemopoietic stem cell
TL;DR: Several experimental findings that are inconsistent with the view that the spleen colony-forming cell (CFU-S) is the primary haemopoietic stem cell are reviewed and a hypothesis is proposed in which the stem cell is seen in association with other cells which determine its behaviour.
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