Journal ArticleDOI
Sarcopenia in hiding: The risk and consequence of underestimating muscle dysfunction in nonalcoholic steatohepatitis.
TLDR
The complex inter‐relationships between sarcopenia and NASH is explored and viewing skeletal muscle as an endocrine organ that secretes various salutary myokines may help to understand its role in the development of steatosis.About:
This article is published in Hepatology.The article was published on 2017-12-01. It has received 177 citations till now. The article focuses on the topics: Sarcopenia & Nonalcoholic fatty liver disease.read more
Citations
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Journal ArticleDOI
Sex Differences in Nonalcoholic Fatty Liver Disease: State of the Art and Identification of Research Gaps.
Amedeo Lonardo,Fabio Nascimbeni,Stefano Ballestri,De Lisa Fairweather,Sanda Win,Tin Aung Than,Manal F. Abdelmalek,Ayako Suzuki,Ayako Suzuki +8 more
TL;DR: Clinical trials should be designed to test drug efficacy and safety according to sex, age, reproductive stage (i.e., menopause), and synthetic hormone use, to fill current gaps and implement precision medicine for patients with NAFLD.
Journal ArticleDOI
Sarcopenia and nonalcoholic fatty liver disease: a causal relationship.
TL;DR: NAFLD, particularly its histological phenotype non-alcoholic steatohepatitis (NASH), can progress to advanced liver disease, cirrhosis and hepatocellular carcinoma and indication for liver transplantation.
Journal ArticleDOI
Malnutrition, Frailty, and Sarcopenia in Patients With Cirrhosis: 2021 Practice Guidance by the American Association for the Study of Liver Diseases.
Jennifer C. Lai,Puneeta Tandon,William Bernal,Elliot B. Tapper,Ekong U,Srinivasan Dasarathy,Elizabeth J. Carey +6 more
TL;DR: The first American Association for the Study of Liver Diseases (AASLD) Practice Guidance on the management of malnutrition, frailty, and sarcopenia in patients with cirrhosis is presented in this paper.
Journal ArticleDOI
NASH in Lean Individuals.
Ramy Younes,Elisabetta Bugianesi +1 more
TL;DR: The authors describe the current knowledge about NAFLD in lean individuals and highlight the unanswered questions and gaps in the field.
Journal ArticleDOI
Relationship Between Relative Skeletal Muscle Mass and Nonalcoholic Fatty Liver Disease: A 7-Year Longitudinal Study
Gyuri Kim,Seung Eun Lee,You-Bin Lee,Ji Eun Jun,Jiyeon Ahn,Ji Cheol Bae,Sang-Man Jin,Kyu Yeon Hur,Jae Hwan Jee,Moon-Kyu Lee,Jae Hyeon Kim,Jae Hyeon Kim +11 more
TL;DR: Increases in relative skeletal muscle mass over time may lead to benefits either in the development of NAFLD or the resolution of existingNAFLD.
References
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Journal ArticleDOI
Sarcopenia: European consensus on definition and diagnosis Report of the European Working Group on Sarcopenia in Older People
Alfonso J. Cruz-Jentoft,Jean-Pierre Baeyens,Jürgen M. Bauer,Yves Boirie,Tommy Cederholm,Francesco Landi,Finbarr C. Martin,Jean-Pierre Michel,Yves Rolland,Stéphane M. Schneider,Eva Topinkova,Maurits Vandewoude,Mauro Zamboni +12 more
TL;DR: The European Working Group on Sarcopenia in Older People (EWGSOP) developed a practical clinical definition and consensus diagnostic criteria for age-related sarcopenia as discussed by the authors.
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A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Pontus Boström,Jun Wu,Mark P. Jedrychowski,Anisha Korde,Li Ye,James C. Lo,Kyle A. Rasbach,Elisabeth A. Boström,Jang Hyun Choi,Jonathan Z. Long,Shingo Kajimura,Maria Cristina Zingaretti,Birgitte F. Vind,Hua Tu,Saverio Cinti,Kurt Højlund,Steven P. Gygi,Bruce M. Spiegelman +17 more
TL;DR: This article showed that PGC1α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin.
Journal ArticleDOI
Muscles, exercise and obesity: skeletal muscle as a secretory organ
TL;DR: The finding that the muscle secretome consists of several hundred secreted peptides provides a conceptual basis and a whole new paradigm for understanding how muscles communicate with other organs, such as adipose tissue, liver, pancreas, bones and brain.
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Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis.
Eduardo Vilar-Gomez,Yadina Martinez-Perez,Luis Calzadilla-Bertot,Ana Torres-Gonzalez,Bienvenido Gra-Oramas,Licet Gonzalez-Fabian,Scott L. Friedman,Moisés Diago,Manuel Romero-Gómez +8 more
TL;DR: A greater extent of weight loss, induced by lifestyle changes, is associated with the level of improvement in histologic features of NASH.
Journal ArticleDOI
Low Vitamin D and High Parathyroid Hormone Levels as Determinants of Loss of Muscle Strength and Muscle Mass (Sarcopenia): The Longitudinal Aging Study Amsterdam
TL;DR: The results of this prospective, population-based study show that lower 25-OHD and higher PTH levels increase the risk of sarcopenia in older men and women.