SARS-CoV-2 antibody testing for estimating COVID-19 prevalence in the population.
Thomas Vogl,Sigal Leviatan,Eran Segal +2 more
- Vol. 2, Iss: 2, pp 100191-100191
TLDR
This paper reviewed different types of antibody tests available for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and their application for population-scale testing and concluded that the accuracy of serological tests and selection criteria for the tested cohorts need to be evaluated carefully.Abstract:
Reliable antibody testing against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has the potential to uncover the population-wide spread of coronavirus disease 2019 (COVID-19), which is critical for making informed healthcare and economic decisions. Here we review different types of antibody tests available for SARS-CoV-2 and their application for population-scale testing. Biases because of varying test accuracy, results of ongoing large-scale serological studies, and use of antibody testing for monitoring development of herd immunity are summarized. Although current SARS-CoV-2 antibody testing efforts have generated valuable insights, the accuracy of serological tests and the selection criteria for the tested cohorts need to be evaluated carefully.read more
Citations
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Antibodies against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) in individuals with and without COVID-19 vaccination: A method comparison of two different commercially available serological assays from the same manufacturer.
TL;DR: In this paper, the authors compared two serological assays from Roche Diagnostics in individuals with and without COVID-19 vaccination, namely the Elecsys Anti-SARS-CoV-2 assay (detecting antibodies against the nucleocapsid protein of SARS CoV2) and the Elemsys Anti SARS-coV2 S assay, and found that 62.9% of all determinations were negative with both Roche assays and 31.5% were positive with both assays.
Journal ArticleDOI
Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern.
Courtney Voss,Sally Esmail,Xuguang Liu,Michael J. Knauer,Suzanne Ackloo,Tomonori Kaneko,Lori E. Lowes,Peter J. Stogios,Almagul Seitova,Ashley Hutchinson,Farhad Yusifov,Tatiana Skarina,Elena Evdokimova,Peter Loppnau,Pegah Ghiabi,Taraneh Haijan,Shanshan Zhong,Husam Abdoh,Benjamin D. Hedley,Vipin Bhayana,Claudio Martin,Claudio Martin,Marat Slessarev,Marat Slessarev,Benjamin Chin-Yee,Douglas D. Fraser,Douglas D. Fraser,Ian Chin-Yee,Shawn S.-C. Li +28 more
TL;DR: In this paper, the role of humoral immunity in COVID-19 is not fully understood, owing, in large part, to the complexity of antibodies produced in response to the SARS-CoV-2 infection.
Journal ArticleDOI
Evaluation of a New Spike (S)-Protein-Based Commercial Immunoassay for the Detection of Anti-SARS-CoV-2 IgG.
Kirsten Alexandra Eberhardt,Kirsten Alexandra Eberhardt,Felix Dewald,Eva Heger,Lutz Gieselmann,Kanika Vanshylla,Maike Wirtz,Franziska Kleipass,Wibke Johannis,Philipp Schommers,Henning Gruell,Karl August Brensing,Roman-Ulrich Müller,Max Augustin,Clara Lehmann,Manuel Koch,Florian Klein,Veronica Di Cristanziano +17 more
TL;DR: The novel IDK® anti-SARS-CoV-2 S1 IgG assay showed high sensitivity and specificity, representing a valid option for use in the routine diagnostic and correlated well with serum-neutralizing activity.
Journal ArticleDOI
Coronavirus Disease 2019: Clinics, Treatment, and Prevention.
TL;DR: The coronavirus disease 2019 (COVID-19) pandemic, caused by a novel severe acute respiratory syndrome (SARS-CoV-2) emerged at the end of 2019 in China and affected the entire world population, either by infection and its health consequences, or by restrictions in daily life as a consequence of hygiene measures and containment strategies as mentioned in this paper.
Journal ArticleDOI
Choice of SARS-CoV-2 diagnostic test: challenges and key considerations for the future
Fausto Baldanti,Nirmal Kumar Ganguly,Guiqiang Wang,Martin Möckel,Luke A. J. O'Neill,Harald Renz,C. E. dos Santos Ferreira,Kazuhiro Tateda,Barbara Van Der Pol +8 more
TL;DR: A narrative review aims to summarize the diagnostic technologies available and how they are best selected to tackle SARS-CoV-2 infection as the pandemic evolves, and offers some discussion on the considerations for when other tools and technologies may be useful, when centralized/point-of-care testing is appropriate, and how the various additional diagnostics can be deployed in differently resourced settings.
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Journal ArticleDOI
Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2)
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