SATB1 dictates expression of multiple genes including IL-5 involved in human T helper cell differentiation.
Helena Ahlfors,Amita Limaye,Laura L. Elo,Laura L. Elo,Soile Tuomela,Mithila Burute,Kamalvishnu P. Gottimukkala,Dimple Notani,Omid Rasool,Sanjeev Galande,Riitta Lahesmaa +10 more
TLDR
It is demonstrated that, during the early Th2 cell differentiation, IL-5 expression is repressed through direct binding of SATB1 to the IL- 5 promoter, and it is suggested that a competitive mechanism involving SATB 1 and GATA3 regulates IL-4 transcription.About:
This article is published in Blood.The article was published on 2010-09-02 and is currently open access. It has received 61 citations till now. The article focuses on the topics: Cellular differentiation & Transcription factor.read more
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Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation
Marc Beyer,Yasser Thabet,Roman-Ulrich Müller,Timothy Sadlon,Sabine Classen,Katharina Lahl,Samik Basu,Xuyu Zhou,Samantha L. Bailey-Bucktrout,Wolfgang Krebs,Eva A. Schönfeld,Jan P. Böttcher,Tatiana N. Golovina,Christian T. Mayer,Andrea Hofmann,Daniel Sommer,Svenja Debey-Pascher,Elmar Endl,Andreas Limmer,Keli L. Hippen,Bruce R. Blazar,Robert Balderas,Thomas Quast,Andreas Waha,Günter Mayer,Michael Famulok,Percy A. Knolle,Claudia Wickenhauser,Waldemar Kolanus,Bernhard Schermer,Jeffrey A. Bluestone,Simon C. Barry,Tim Sparwasser,James L. Riley,Joachim L. Schultze +34 more
TL;DR: It is reported that repression of SATB1, a genome organizer that regulates chromatin structure and gene expression, was crucial for the phenotype and function of Treg cells.
Journal ArticleDOI
Transcriptional and epigenetic regulation of T-helper lineage specification.
TL;DR: Recent studies on the transcriptional and epigenetic regulation of distinct Th cell lineages are reviewed and current study linking immune disease‐associated single‐nucleotide polymorphisms with distal regulatory elements and their potential role in the disease etiology are reviewed.
Journal ArticleDOI
The Bcl6 target gene microRNA-21 promotes Th2 differentiation by a T cell intrinsic pathway.
TL;DR: MiR21 expression is increased in Th2-type inflammation, and the results reveal a novel T cell autonomous role for miR-21 in promoting Th2 differentiation, thus providing a new link between Bcl6 and Th2 inflammation.
Journal ArticleDOI
Upregulation of SATB1 promotes tumor growth and metastasis in liver cancer
TL;DR: Special AT‐rich binding protein‐1 (SATB1) reprograms chromatin organization and transcription profiles to promote tumour growth and metastasis.
Journal ArticleDOI
Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma
Grégory Seumois,Ciro Ramírez-Suástegui,Benjamin J Schmiedel,Shu Liang,Bjoern Peters,Bjoern Peters,Alessandro Sette,Alessandro Sette,Pandurangan Vijayanand,Pandurangan Vijayanand,Pandurangan Vijayanand +10 more
TL;DR: It is suggested that the THIFNR and TregIFNR subsets may dampen allergic responses, which may help explain why only some people develop TH2 responses to nearly ubiquitous allergens.
References
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Tim R. Mosmann,R L Coffman +1 more
TL;DR: Two types of cloned helper T cells are described, defined primarily by differences in the pattern of lymphokines ynthesized, and the different functions of the two types of cells and their lymphokine synthesis are discussed.
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Interleukin 17–producing CD4 + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Laurie E. Harrington,Robin D. Hatton,Paul R. Mangan,Henrietta Turner,Theresa L. Murphy,Kenneth M. Murphy,Casey T. Weaver +6 more
TL;DR: Findings provide a basis for understanding how inhibition of IFN-γ signaling enhances development of pathogenic TH-17 effector cells that can exacerbate autoimmunity.