Schwannomin isoform-1 interacts with syntenin via PDZ domains.
Mehrdad Jannatipour,Patrick A. Dion,Saad A. Khan,Hitesh K. Jindal,Xueping Fan,Janet Laganière,Athar H. Chishti,Guy A. Rouleau +7 more
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TLDR
Using the yeast two-hybrid system, syntenin is identified as a binding partner for schwannomin isoform-1 (sch-1) and it is showed that the two proteins interact in vitro and in vivo and localized underneath the plasma membrane.About:
This article is published in Journal of Biological Chemistry.The article was published on 2001-08-31 and is currently open access. It has received 82 citations till now. The article focuses on the topics: PDZ domain & Merlin (protein).read more
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Function of alternative splicing.
Stefan Stamm,Shani Ben-Ari,Ilona Rafalska,Yesheng Tang,Zhaiyi Zhang,Debra Toiber,Thangavel Alphonse Thanaraj,Hermona Soreq +7 more
TL;DR: Evidence is now accumulating that alternative splicing coordinates physiologically meaningful changes in protein isoform expression and is a key mechanism to generate the complex proteome of multicellular organisms.
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Histological classification and molecular genetics of meningiomas.
TL;DR: The most common genetic alterations associated with the initiation of meningiomas are mutations in the NF2 gene and loss of chromosome 22q as mentioned in this paper, however, most of the relevant genes are yet to be identified.
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PDZ domains and their binding partners: structure, specificity, and modification
Ho-Jin Lee,Jie Zheng +1 more
TL;DR: The structural characterization of PDZ domains is discussed and the use of recently emerging technologies such as proteomic arrays and peptide libraries to study the binding properties ofPDZ-mediated interactions are discussed.
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Pathological classification and molecular genetics of meningiomas
Christian Mawrin,Arie Perry +1 more
TL;DR: The integration of histopathological appearance, complex genetic/genomic data, and outcome will likely result in the identification of clinically distinct meningioma subgroups, which in turn can facilitate the development of targeted therapeutic strategies.
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Advances in Bioconjugation.
Jeet Kalia,Ronald T. Raines +1 more
TL;DR: The stability of bioconjugation linkages is discussed-an important but often overlooked aspect of the field and it is hoped that this information will help investigators choose optimal linkages for their applications.
References
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Mutation and Cancer: Statistical Study of Retinoblastoma
TL;DR: The hypothesis is developed that retinoblastoma is a cancer caused by two mutational events, in the dominantly inherited form, one mutation is inherited via the germinal cells and the second occurs in somatic cells.
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A novel genetic system to detect protein-protein interactions.
Stanley Fields,Ok-kyu Song +1 more
TL;DR: A novel genetic system to study protein-protein interactions between two proteins by taking advantage of the properties of the GAL4 protein of the yeast Saccharomyces cerevisiae, which may be applicable as a general method to identify proteins that interact with a known protein by the use of a simple galactose selection.
Journal ArticleDOI
Recognition of unique carboxyl-terminal motifs by distinct PDZ domains
Zhou Songyang,Alan S. Fanning,C. Fu,Jian Xu,Shirin M. Marfatia,Athar H. Chishti,Anne M. Crompton,Andrew C. Chan,James M. Anderson,Lewis C. Cantley +9 more
TL;DR: On the basis of crystal structures of the PSD-95-3 PDZ domain, the specificities observed with the peptide library can be rationalized.
Journal ArticleDOI
Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2
Guy A. Rouleau,P. Merel,Mohini Lutchman,Marc Sanson,Marc Sanson,Jessica Zucman,Claude Marineau,Khê Hoang-Xuan,S. Demczuk,Chantal Desmaze,Béatrice Plougastel,Stefan M. Pulst,Gilbert M. Lenoir,E. K. Bijlsma,Raimund Fashold,Jan P. Dumanski,Pieter J. de Jong,Dilys M. Parry,Roswell Eldrige,Alain Aurias,Olivier Delattre,Gilles Thomas +21 more
TL;DR: The deduced product has homology with proteins at the plasma membrane and cytoskeleton Interface, a previously unknown site of action of tumour suppressor genes in humans.
Journal ArticleDOI
A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor
James A. Trofatter,Mia MacCollin,Joni L. Rutter,Jill R. Murrell,Mabel P. Duyao,Dilys M. Parry,Roswell Eldridge,Nikolai Kley,Anil G. Menon,K Pulaski,Volker H. Haase,Christine Ambrose,David J. Munroe,Catherine Bove,Jonathan L. Haines,Robert L. Martuza,Marcy E. MacDonald,Bernd R. Seizinger,M. Priscilla Short,Alan Buckler,James F. Gusella +20 more
TL;DR: A candidate gene for the NF2 tumor suppressor that has suffered nonoverlapping deletions in DNA from two independent NF2 families and alterations in meningiomas from two unrelated NF2 patients is identified.
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