Searching for an Operational Definition of Frailty: A Delphi Method Based Consensus Statement. The Frailty Operative Definition-Consensus Conference Project
Leocadio Rodríguez-Mañas,Catherine Féart,Catherine Féart,Giovanni E. Mann,Jose Viña,Somnath Chatterji,Wojtek Chodzko-Zajko,Magali Gonzalez-Colaço Harmand,Howard Bergman,Laure Carcaillon,Caroline Nicholson,Angelo Scuteri,Alan J. Sinclair,Martha Peláez,Tischa J. M. van der Cammen,François Béland,Jerome Bickenbach,Paul Delamarche,Luigi Ferrucci,Linda P. Fried,Luis Miguel Gutiérrez-Robledo,Kenneth Rockwood,Fernando Rodríguez Artalejo,Gaetano Serviddio,Enrique Vega +24 more
TLDR
There is agreement on the usefulness of defining frailty in clinical settings as well as on its main dimensions, however, additional research is needed before an operative definition of frailty can be established.Abstract:
BACKGROUND: There is no consensus regarding the definition of frailty for clinical uses. METHODS: A modified Delphi process was used to attempt to achieve consensus definition. Experts were selected from different fields and organized into five Focus Groups. A questionnaire was developed and sent to experts in the area of frailty. Responses and comments were analyzed using a pre-established strategy. Statements with an agreement more than or equal to 80% were accepted. RESULTS: Overall, 44% of the statements regarding the concept of frailty and 18% of the statements regarding diagnostic criteria were accepted. There was consensus on the value of screening for frailty and about the identification of six domains of frailty for inclusion in a clinical definition, but no agreement was reached concerning a specific set of clinical/laboratory biomarkers useful for diagnosis. CONCLUSIONS: There is agreement on the usefulness of defining frailty in clinical settings as well as on its main dimensions. However, additional research is needed before an operative definition of frailty can be established.read more
Citations
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Journal ArticleDOI
Frailty Consensus: A Call to Action
John E. Morley,Bruno Vellas,G. Abellan Van Kan,Stefan D. Anker,Juergen M. Bauer,Roberto Bernabei,Matteo Cesari,Wm. Cameron Chumlea,Wolfram Doehner,Jonathan Evans,Linda P. Fried,Jack M. Guralnik,Paul R. Katz,Theodore K. Malmstrom,Roger McCarter,Luis Miguel Francisco Gutierrez Robledo,Kenneth Rockwood,Stephan von Haehling,Maurits Vandewoude,Jeremy D. Walston +19 more
TL;DR: For the purposes of optimally managing individuals with physical frailty, all persons older than 70 years and all individuals with significant weight loss (>5%) due to chronic disease should be screened for frailty.
Journal ArticleDOI
Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group
Juergen M. Bauer,Gianni Biolo,Tommy Cederholm,Matteo Cesari,Alfonso J. Cruz-Jentoft,John E. Morley,Stuart M. Phillips,Cornel C. Sieber,Peter Stehle,Daniel Teta,Renuka Visvanathan,Elena Volpi,Yves Boirie +12 more
TL;DR: To help older people (>65 years) maintain and regain lean body mass and function, the PROT-AGE study group recommends average daily intake at least in the range of 1.2 g protein per kilogram of body weight per day.
Journal ArticleDOI
Frailty measurement in research and clinical practice: A review
TL;DR: How well these measurements operationalise frailty according to Clegg's guidelines for frailty classification is examined - that is: their accuracy in identifying frailty; their basis on biological causative theory; and their ability to reliably predict patient outcomes and response to potential therapies.
Journal ArticleDOI
Effects of different exercise interventions on risk of falls, gait ability and balance in physically frail older adults. A systematic review
TL;DR: The multi-component exercise intervention composed by strength, endurance and balance training seems to be the best strategy to improve rate of falls, gait ability, balance, and strength performance in physically frail older adults.
Journal ArticleDOI
Cognitive frailty: Rational and definition from an (I.A.N.A./I.A.G.G.) International Consensus Group
Eirini Kelaiditi,Matteo Cesari,Matteo Cesari,Marco Canevelli,G. Abellan Van Kan,P.J. Ousset,Sophie Gillette-Guyonnet,Patrick Ritz,F. Duveau,Maria Soto,Véronique Provencher,Fati Nourhashemi,Antoni Salvà,Philippe Robert,S. Andrieu,Yves Rolland,Jacques Touchon,Jaime Fitten,Bruno Vellas,Bruno Vellas +19 more
TL;DR: The present report provides the first definition of a “Cognitive Frailty” condition in older adults and proposes the use of multidomain interventions focused on the physical, nutritional, cognitive and psychological domains for improving the well-being and quality of life in the elderly.
References
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Journal ArticleDOI
Outcome instruments to measure frailty: A systematic review
N.M. de Vries,J.B. Staal,C.D. van Ravensberg,Johannes S. M. Hobbelen,M.G.M. Olde Rikkert,M.W.G. Nijhuis-van der Sanden +5 more
TL;DR: A systematic review on evaluative measures of frailty was performed in the databases PubMed, EMBASE, Cinahl and Cochrane to give a clear overview of the content and clinimetric properties of several frailty instruments.
The delphi technique: making sense of consensus practical assessment
Chia-Chien Hsu,Brian A. Sandford +1 more
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The Delphi method: Substance, context, a critique and an annotated bibliography
TL;DR: The methodology and its historical development are described, it is placed in context vis-a-vis other methods of subjective scaling, and a critique is provided.
Journal ArticleDOI
Cognitive Impairment Improves the Predictive Validity of the Phenotype of Frailty for Adverse Health Outcomes: The Three-City Study
José Alberto Avila-Funes,Hélène Amieva,Pascale Barberger-Gateau,Mélanie Le Goff,Nadine Raoux,Karen Ritchie,Isabelle Carrière,Béatrice Tavernier,Christophe Tzourio,Luis Miguel Gutiérrez-Robledo,Jean-François Dartigues +10 more
TL;DR: To determine whether adding cognitive impairment to frailty improves its predictive validity for adverse health outcomes, a study of memory loss in elderly people with dementia is conducted.
Journal ArticleDOI
Redefining geriatric preoperative assessment using frailty, disability and co-morbidity.
Thomas N. Robinson,Ben Eiseman,Jeffrey I. Wallace,Skotti Church,Kim McFann,Shirley M. Pfister,Terra J. Sharp,Marc Moss +7 more
TL;DR: Geriatric assessment markers for frailty, disability and comorbidity predict 6-month postoperative mortality and postdischarge institutionalization and preoperative assessment using geriatric-specific markers is a substantial paradigm shift from the traditional preoperative evaluation of older adults.
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