Searching for an Operational Definition of Frailty: A Delphi Method Based Consensus Statement. The Frailty Operative Definition-Consensus Conference Project
Leocadio Rodríguez-Mañas,Catherine Féart,Catherine Féart,Giovanni E. Mann,Jose Viña,Somnath Chatterji,Wojtek Chodzko-Zajko,Magali Gonzalez-Colaço Harmand,Howard Bergman,Laure Carcaillon,Caroline Nicholson,Angelo Scuteri,Alan J. Sinclair,Martha Peláez,Tischa J. M. van der Cammen,François Béland,Jerome Bickenbach,Paul Delamarche,Luigi Ferrucci,Linda P. Fried,Luis Miguel Gutiérrez-Robledo,Kenneth Rockwood,Fernando Rodríguez Artalejo,Gaetano Serviddio,Enrique Vega +24 more
TLDR
There is agreement on the usefulness of defining frailty in clinical settings as well as on its main dimensions, however, additional research is needed before an operative definition of frailty can be established.Abstract:
BACKGROUND: There is no consensus regarding the definition of frailty for clinical uses. METHODS: A modified Delphi process was used to attempt to achieve consensus definition. Experts were selected from different fields and organized into five Focus Groups. A questionnaire was developed and sent to experts in the area of frailty. Responses and comments were analyzed using a pre-established strategy. Statements with an agreement more than or equal to 80% were accepted. RESULTS: Overall, 44% of the statements regarding the concept of frailty and 18% of the statements regarding diagnostic criteria were accepted. There was consensus on the value of screening for frailty and about the identification of six domains of frailty for inclusion in a clinical definition, but no agreement was reached concerning a specific set of clinical/laboratory biomarkers useful for diagnosis. CONCLUSIONS: There is agreement on the usefulness of defining frailty in clinical settings as well as on its main dimensions. However, additional research is needed before an operative definition of frailty can be established.read more
Citations
More filters
Journal ArticleDOI
Computed Tomography-based Body Composition Analysis and Its Role in Lung Cancer Care.
Amelie S. Troschel,Fabian M. Troschel,Till D. Best,Henning A. Gaissert,Martin Torriani,Ashok Muniappan,Emily E. Van Seventer,Ryan D. Nipp,Eric Roeland,Jennifer S. Temel,Florian J. Fintelmann +10 more
TL;DR: The purpose of this review is to provide an overview of the concepts, definitions, assessment tools, segmentation techniques and associated pitfalls, interpretation of those measurements on chest and abdomen CT, and a discussion of reported outcomes associated with body composition metrics in patients with early-stage and advanced lung cancer.
Journal ArticleDOI
Predictive performance of four frailty measures in an older Australian population
TL;DR: Being identified as frail by any of the four frailty measures was associated with an increased risk of outcomes; however, their predictive accuracy varied.
Book
Inflammation, advancing age and nutrition
Irfan Rahman,Debasis Bagchi +1 more
TL;DR: This book explores the relationship of inflammation with diseases, including ocular health, Alzheimer's and Parkinson's disease, and muscle health andcompasses a variety of lifestyle impacts, including diet, exercise and nutrition.
Journal ArticleDOI
Relevance of oxidative stress and inflammation in frailty based on human studies and mouse models.
María Álvarez-Satta,Alejandro Berna-Erro,Estefania Carrasco-Garcia,Ainhoa Alberro,Ander Saenz-Antoñanzas,Itziar Vergara,David Otaegui,Ander Matheu +7 more
TL;DR: The current available evidence is provided, from both human cohorts and experimental animal models, that highlights oxidative damage and inflammation as relevant biomarkers and drivers of frailty.
Journal ArticleDOI
The association between decreased hand grip strength and hip fracture in older people: A systematic review.
TL;DR: HGS merits further investigation as a useful tool for identifying individuals that might be at elevated risk for sustaining a hip fracture, due to the heterogeneity of the included studies.
References
More filters
Journal ArticleDOI
Frailty in Older Adults Evidence for a Phenotype
Linda P. Fried,Catherine M. Tangen,Jeremy D. Walston,Anne B. Newman,Calvin H. Hirsch,John S. Gottdiener,Teresa E. Seeman,Russell P. Tracy,Willem J. Kop,B Gregory Burke,Mary Ann McBurnie +10 more
TL;DR: This study provides a potential standardized definition for frailty in community-dwelling older adults and offers concurrent and predictive validity for the definition, and finds that there is an intermediate stage identifying those at high risk of frailty.
Journal Article
Cardiovascular Health Study Collaborative Research Group : Frailty in older adults : evidence for a phenotype
Book
the delphi method: techniques and applications
Harold A. Linstone,Murray Turoff +1 more
TL;DR: The present model clarifies some of the conceptual problems associated with cross-impact analysis, and supplies a relatively sound basis for revising probability estimates in the limited case where interactions can be approximated by relative probabilities.
Journal ArticleDOI
The Delphi Technique: Making Sense of Consensus
Chia-Chien Hsu,Brian A. Sandford +1 more
TL;DR: The Delphi technique is well suited as a method for consensus-building by using a series of questionnaires delivered using multiple iterations to collect data from a panel of selected subjects.
Journal ArticleDOI
Classificação Internacional de Funcionalidade (CIF)
TL;DR: The present article has the objective of updating rehabilitation health professionals on the International Classification of Functioning Disability and Health (ICF) developed by the World Health Organization.
Related Papers (5)
Frailty Consensus: A Call to Action
John E. Morley,Bruno Vellas,G. Abellan Van Kan,Stefan D. Anker,Juergen M. Bauer,Roberto Bernabei,Matteo Cesari,Wm. Cameron Chumlea,Wolfram Doehner,Jonathan Evans,Linda P. Fried,Jack M. Guralnik,Paul R. Katz,Theodore K. Malmstrom,Roger McCarter,Luis Miguel Francisco Gutierrez Robledo,Kenneth Rockwood,Stephan von Haehling,Maurits Vandewoude,Jeremy D. Walston +19 more