Searching for an Operational Definition of Frailty: A Delphi Method Based Consensus Statement. The Frailty Operative Definition-Consensus Conference Project
Leocadio Rodríguez-Mañas,Catherine Féart,Catherine Féart,Giovanni E. Mann,Jose Viña,Somnath Chatterji,Wojtek Chodzko-Zajko,Magali Gonzalez-Colaço Harmand,Howard Bergman,Laure Carcaillon,Caroline Nicholson,Angelo Scuteri,Alan J. Sinclair,Martha Peláez,Tischa J. M. van der Cammen,François Béland,Jerome Bickenbach,Paul Delamarche,Luigi Ferrucci,Linda P. Fried,Luis Miguel Gutiérrez-Robledo,Kenneth Rockwood,Fernando Rodríguez Artalejo,Gaetano Serviddio,Enrique Vega +24 more
TLDR
There is agreement on the usefulness of defining frailty in clinical settings as well as on its main dimensions, however, additional research is needed before an operative definition of frailty can be established.Abstract:
BACKGROUND: There is no consensus regarding the definition of frailty for clinical uses. METHODS: A modified Delphi process was used to attempt to achieve consensus definition. Experts were selected from different fields and organized into five Focus Groups. A questionnaire was developed and sent to experts in the area of frailty. Responses and comments were analyzed using a pre-established strategy. Statements with an agreement more than or equal to 80% were accepted. RESULTS: Overall, 44% of the statements regarding the concept of frailty and 18% of the statements regarding diagnostic criteria were accepted. There was consensus on the value of screening for frailty and about the identification of six domains of frailty for inclusion in a clinical definition, but no agreement was reached concerning a specific set of clinical/laboratory biomarkers useful for diagnosis. CONCLUSIONS: There is agreement on the usefulness of defining frailty in clinical settings as well as on its main dimensions. However, additional research is needed before an operative definition of frailty can be established.read more
Citations
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Hallmarks of frailty and osteosarcopenia in prematurely aged PolgA(D257A/D257A) mice.
Ariane C. Scheuren,Gommaar D'Hulst,Gisela A. Kuhn,Evi Masschelein,Esther Wehrle,Katrien De Bock,Ralph Müller +6 more
TL;DR: PolgA(D257A/D 257A) mutation leads to hallmarks of age‐related frailty and osteosarcopenia and provides a powerful model to better understand the relationship between frailtyand the aging musculoskeletal system.
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Prediction of mortality in Chinese very old people through the frailty index based on routine laboratory data.
TL;DR: The increased risk of death in older adults can be successfully identified through frailty index (FI), based on comprehensive geriatric assessment data and self-reported data from the accumulated deficit, although the method depending on routine laboratory data (FI-LAB) remains uncertain.
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Sarcopenia: a clinical review
TL;DR: This review focuses on the incorporation of sarc Openia into clinical practice, reviews case finding and diagnosis, proposes a syndromic approach for the diagnostic work-up of sarcopenic patients, and looks at intervention trials with physical exercise and nutrition, as drugs to treat this condition are not expected to be available in the near future.
Journal ArticleDOI
Defining Frailty in Research Abstracts: A Systematic Review and Recommendations for Standardization.
Enzo Yaksic,V. Lecky,S. Sharnprapai,T. Tungkhar,Kelly Cho,Jane A. Driver,Jane A. Driver,Ariela R. Orkaby +7 more
TL;DR: A systematic review of MEDLINE/PubMed for English abstracts of original research investigating frailty as an exposure or outcome in humans from 2015–2017 found that frailty is insufficiently defined in published abstracts and encourages scientists to adopt a standardized approach to defining the term.
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Systolic Blood Pressure and Mortality in Community-Dwelling Older Adults: Frailty as an Effect Modifier
TL;DR: In this article , the authors evaluated whether frailty modifies the association between systolic blood pressure (SBP) and 8-year all-cause mortality in community-dwelling older adults.
References
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Journal ArticleDOI
Frailty in Older Adults Evidence for a Phenotype
Linda P. Fried,Catherine M. Tangen,Jeremy D. Walston,Anne B. Newman,Calvin H. Hirsch,John S. Gottdiener,Teresa E. Seeman,Russell P. Tracy,Willem J. Kop,B Gregory Burke,Mary Ann McBurnie +10 more
TL;DR: This study provides a potential standardized definition for frailty in community-dwelling older adults and offers concurrent and predictive validity for the definition, and finds that there is an intermediate stage identifying those at high risk of frailty.
Journal Article
Cardiovascular Health Study Collaborative Research Group : Frailty in older adults : evidence for a phenotype
Book
the delphi method: techniques and applications
Harold A. Linstone,Murray Turoff +1 more
TL;DR: The present model clarifies some of the conceptual problems associated with cross-impact analysis, and supplies a relatively sound basis for revising probability estimates in the limited case where interactions can be approximated by relative probabilities.
Journal ArticleDOI
The Delphi Technique: Making Sense of Consensus
Chia-Chien Hsu,Brian A. Sandford +1 more
TL;DR: The Delphi technique is well suited as a method for consensus-building by using a series of questionnaires delivered using multiple iterations to collect data from a panel of selected subjects.
Journal ArticleDOI
Classificação Internacional de Funcionalidade (CIF)
TL;DR: The present article has the objective of updating rehabilitation health professionals on the International Classification of Functioning Disability and Health (ICF) developed by the World Health Organization.
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