Searching for an Operational Definition of Frailty: A Delphi Method Based Consensus Statement. The Frailty Operative Definition-Consensus Conference Project
Leocadio Rodríguez-Mañas,Catherine Féart,Catherine Féart,Giovanni E. Mann,Jose Viña,Somnath Chatterji,Wojtek Chodzko-Zajko,Magali Gonzalez-Colaço Harmand,Howard Bergman,Laure Carcaillon,Caroline Nicholson,Angelo Scuteri,Alan J. Sinclair,Martha Peláez,Tischa J. M. van der Cammen,François Béland,Jerome Bickenbach,Paul Delamarche,Luigi Ferrucci,Linda P. Fried,Luis Miguel Gutiérrez-Robledo,Kenneth Rockwood,Fernando Rodríguez Artalejo,Gaetano Serviddio,Enrique Vega +24 more
TLDR
There is agreement on the usefulness of defining frailty in clinical settings as well as on its main dimensions, however, additional research is needed before an operative definition of frailty can be established.Abstract:
BACKGROUND: There is no consensus regarding the definition of frailty for clinical uses. METHODS: A modified Delphi process was used to attempt to achieve consensus definition. Experts were selected from different fields and organized into five Focus Groups. A questionnaire was developed and sent to experts in the area of frailty. Responses and comments were analyzed using a pre-established strategy. Statements with an agreement more than or equal to 80% were accepted. RESULTS: Overall, 44% of the statements regarding the concept of frailty and 18% of the statements regarding diagnostic criteria were accepted. There was consensus on the value of screening for frailty and about the identification of six domains of frailty for inclusion in a clinical definition, but no agreement was reached concerning a specific set of clinical/laboratory biomarkers useful for diagnosis. CONCLUSIONS: There is agreement on the usefulness of defining frailty in clinical settings as well as on its main dimensions. However, additional research is needed before an operative definition of frailty can be established.read more
Citations
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Biology of frailty: Modulation of ageing genes and its importance to prevent age-associated loss of function.
Jose Viña,Francisco José Tarazona-Santabalbina,Pilar Pérez-Ros,Francisco Miguel Martínez-Arnau,Consuelo Borrás,Gloria Olaso-Gonzalez,Andrea Salvador-Pascual,Mari Carmen Gomez-Cabrera +7 more
TL;DR: It is proposed that biological and genetic markers of frailty should be used to increase the predictive capacity of the established clinical indeces to identify frailty risk, and also pre-frailty status.
Journal ArticleDOI
Understanding frailty: a qualitative study of European healthcare policy-makers' approaches to frailty screening and management
Holly Gwyther,Rachel L. Shaw,Eva-Amparo Jaime Dauden,Barbara D'Avanzo,Donata Kurpas,Maria Magdalena Bujnowska-Fedak,Tomasz Kujawa,Maura Marcucci,Antonio Cano,Carol Holland +9 more
TL;DR: There is potential for frailty to be managed in a more integrated and person-centred manner, overcoming the challenges associated with niche ownership within the healthcare system.
Journal ArticleDOI
Predicting Adverse Health Outcomes in Nursing Homes: A 9-Year Longitudinal Study and Development of the FRAIL-Minimum Data Set (MDS) Quick Screening Tool
Hao Luo,Hao Luo,Terry Lum,Gloria H.Y. Wong,Gloria H.Y. Wong,Joseph Kwan,Joseph Kwan,Jennifer Y.M. Tang,Iris Chi +8 more
TL;DR: The FRAIL-NH is a quick screening tool that can be used to identify frail and prefrail nursing home residents at risk of adverse health outcomes and can be applied using variables from the Minimum Data Set, allowing direct adoption in long-term care facilities already using this health information system.
Journal ArticleDOI
Frailty and mortality or incident disability in institutionalized older adults: the FINAL study.
Marisa de la Rica-Escuín,Julia González-Vaca,Rosana Varela-Pérez,María Dolores Arjonilla-García,Marta Silva-Iglesias,José Luis Oliver-Carbonell,Pedro Abizanda +6 more
TL;DR: In a cohort of institutionalized older adults, frailty was associated with mortality or incident disability in basic activities of daily living in BADL (p<0.001), andFrailty wasassociated with incident disability or mortality (OR 3.3; 95% CI 1.7-6.6) adjusted for all study covariables.
Journal ArticleDOI
A New Frailty Score for Experimental Animals Based on the Clinical Phenotype: Inactivity as a Model of Frailty.
Mari Carmen Gomez-Cabrera,Rebeca Garcia-Valles,Leocadio Rodríguez-Mañas,Francisco José García-García,Gloria Olaso-Gonzalez,Andrea Salvador-Pascual,Francisco José Tarazona-Santabalbina,Jose Viña +7 more
TL;DR: The frailty score provides a tool to evaluate interventions in mice prior to translating them to clinical practice and indicates physical inactivity is a model of frailty in experimental animals.
References
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Journal ArticleDOI
Frailty in Older Adults Evidence for a Phenotype
Linda P. Fried,Catherine M. Tangen,Jeremy D. Walston,Anne B. Newman,Calvin H. Hirsch,John S. Gottdiener,Teresa E. Seeman,Russell P. Tracy,Willem J. Kop,B Gregory Burke,Mary Ann McBurnie +10 more
TL;DR: This study provides a potential standardized definition for frailty in community-dwelling older adults and offers concurrent and predictive validity for the definition, and finds that there is an intermediate stage identifying those at high risk of frailty.
Journal Article
Cardiovascular Health Study Collaborative Research Group : Frailty in older adults : evidence for a phenotype
Book
the delphi method: techniques and applications
Harold A. Linstone,Murray Turoff +1 more
TL;DR: The present model clarifies some of the conceptual problems associated with cross-impact analysis, and supplies a relatively sound basis for revising probability estimates in the limited case where interactions can be approximated by relative probabilities.
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The Delphi Technique: Making Sense of Consensus
Chia-Chien Hsu,Brian A. Sandford +1 more
TL;DR: The Delphi technique is well suited as a method for consensus-building by using a series of questionnaires delivered using multiple iterations to collect data from a panel of selected subjects.
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Classificação Internacional de Funcionalidade (CIF)
TL;DR: The present article has the objective of updating rehabilitation health professionals on the International Classification of Functioning Disability and Health (ICF) developed by the World Health Organization.
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