Seroprevalence of human herpesvirus-8 (HHV-8) in countries of Southeast Asia compared to the USA, the Caribbean and Africa
D Ablashi,L Chatlynne,H. Cooper,D. Thomas,M. Yadav,A. W. Norhanom,A K Chandana,V. Churdboonchart,S A R Kulpradist,M. Patnaik,K Liegmann,Rizwan Masood,Marvin S. Reitz,Farley R. Cleghorn,A Manns,Paul H. Levine,Charles S. Rabkin,Robert J. Biggar,F. Jensen,Parkash S. Gill,Noreen Jack,Jeffrey G. Edwards,J Whitman,Chris Boshoff +23 more
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TLDR
Nasopharyngeal and oral carcinoma patients from Malaysia, Hong Kong and Sri Lanka who have very high EBV titres show that there is little, if any, cross-reactivity between antibodies to these two gamma viruses, suggesting that human herpes virus-8 (HHV-8) may be either a recently introduced virus or one that has extremely low infectivity.Abstract:
Seroprevalence of HHV-8 has been studied in Malaysia, India, Sri Lanka, Thailand, Trinidad, Jamaica and the USA, in both healthy individuals and those infected with HIV. Seroprevalence was found to be low in these countries in both the healthy and the HIV-infected populations. This correlates with the fact that hardly any AIDS-related Kaposi's sarcoma has been reported in these countries. In contrast, the African countries of Ghana, Uganda and Zambia showed high seroprevalences in both healthy and HIV-infected populations. This suggests that human herpes virus-8 (HHV-8) may be either a recently introduced virus or one that has extremely low infectivity. Nasopharyngeal and oral carcinoma patients from Malaysia, Hong Kong and Sri Lanka who have very high EBV titres show that only 3/82 (3.7%) have antibody to HHV-8, demonstrating that there is little, if any, cross-reactivity between antibodies to these two gamma viruses.read more
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References
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Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
Yuan Chang,Ethel Cesarman,Melissa S. Pessin,Frank Lee,Janice Culpepper,Daniel M. Knowles,Patrick S. Moore +6 more
TL;DR: unique sequences present in more than 90 percent of Kaposi's sarcoma tissues obtained from patients with acquired immunodeficiency syndrome (AIDS) appear to define a new human herpesvirus.
Journal ArticleDOI
KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma.
Shou-Jiang Gao,Lawrence A. Kingsley,Ming Li,Wei Zheng,Carlo Parravicini,J Ziegler,Robert U. Newton,Charles R. Rinaldo,Alfred J. Saah,John P. Phair,Roger Detels,Yuan Chang,Patrick S. Moore +12 more
TL;DR: Antibody kinetics showed that more than half of the AIDS–KS patients who were examined IgG–seroconverted before KS development, and antibody levels did not decline after seroconversion, suggest that the rate of infection was constant and that the risk of developing KS once infected with KSHV is not highly dependent on the duration of infection.
Journal ArticleDOI
The seroepidemiology of human herpesvirus 8 (kaposi’s sarcoma-associated herpesvirus): distribution of infection in ks risk groups and evidence for sexual transmission
TL;DR: The data support the inference that this virus is the etiologic cofactor predicted by the epidemiology of KS, and the distribution of HHV8 seropositivity conforms to that expected for a sexually transmitted pathogen and tracks closely with the risk for KS development.
Journal ArticleDOI
Sexual Transmission and the Natural History of Human Herpesvirus 8 Infection
TL;DR: The prevalence of HHV-8 infection is high among homosexual men, correlates with the number of homosexual partners, and is temporally and independently associated with Kaposi's sarcoma.
Journal ArticleDOI
Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen
Guy Simpson,Thomas F. Schulz,Denise Whitby,Pamela M. Cook,Chris Boshoff,Lucille Rainbow,Mark R Howard,Shou-Jiang Gao,Roy A. Bohenzky,Peter Simmonds,C. A. Lee,A de Ruiter,Angelos Hatzakis,Richard S. Tedder,Ian Weller,R A Weiss,Patrick S. Moore +16 more
TL;DR: The distribution of antibodies to both a capsid-related recombinant protein and latent antigen of KSHV strongly supports the view that infection with this virus is largely confined to individuals with, or at increased risk for, KS.