Journal ArticleDOI
Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation.
TLDR
Accumulating evidence demonstrates that the phospho-regulation of cofilin/ADF is a key convergence point of cell signaling networks that link extracellular stimuli to actin cytoskeletal dynamics and that spatiotemporal control of coFilin/ ADF activity by LIMKs and SSHs plays a crucial role in a diverse array of cellular and physiological processes.About:
This article is published in Cellular Signalling.The article was published on 2013-02-01. It has received 317 citations till now. The article focuses on the topics: Cofilin & Lim kinase.read more
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Journal ArticleDOI
Actin and Actin-Binding Proteins
TL;DR: This review provides an overview of the properties of actin and shows how dozens of proteins control both the assembly and disassembly of actIn filaments, including nucleotide exchange on actin monomers, polymerization, phosphate dissociation, cap the ends of polymers, cross-link filaments to each other and other cellular components, and sever filaments.
Journal ArticleDOI
Phagocytosis: receptors, signal integration, and the cytoskeleton.
TL;DR: This review addresses the various receptor types, their mobility in the plane of the membrane, and two modes of receptor crosstalk: priming and synergy.
Journal ArticleDOI
Functions of cofilin in cell locomotion and invasion
Jose Javier Bravo-Cordero,Marco A. O. Magalhaes,Marco A. O. Magalhaes,Robert J. Eddy,Louis Hodgson,John S. Condeelis +5 more
TL;DR: These results have been integrated with recently discovered mechanisms for cofilin activation in migrating cells, which led to new models for coFilin function that provide insights into how co Filin regulation determines the temporal and spatial control of cell behaviour.
Journal ArticleDOI
A Synaptic Perspective of Fragile X Syndrome and Autism Spectrum Disorders.
TL;DR: It is inferred that there is no single pathway that explains most of the etiology of fragile X syndrome and related ASDs, and new findings and the implications for future work directed at improving the understanding of the pathogenesis and the design of therapeutic strategies to ameliorate these disorders.
Journal ArticleDOI
Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking
TL;DR: It is shown that the actin cytoskeleton remodelling controls ciliogenesis by regulating transcriptional coactivator YAP/TAZ as well as ciliary vesicle trafficking, which identifies actin remodelling factors LIMK2 and TESK1 as key players in the ciliogenic control network in which YAP-TAZ and directional vesicles trafficking are integral components.
References
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Molecular Cell Biology
TL;DR: Molecular cell biology, Molecular cell biology , مرکز فناوری اطلاعات و اصاع رسانی, کδاوρزی
Journal ArticleDOI
Rho GTPases in cell biology.
TL;DR: Rho GTPases are molecular switches that control a wide variety of signal transduction pathways in all eukaryotic cells and their ability to influence cell polarity, microtubule dynamics, membrane transport pathways and transcription factor activity is probably just as significant.
Journal ArticleDOI
Cellular Motility Driven by Assembly and Disassembly of Actin Filaments
Thomas D. Pollard,Gary G. Borisy +1 more
TL;DR: A core set of proteins including actin, Arp2/3 complex, profilin, capping protein, and ADF/cofilin can reconstitute the process in vitro, and mathematical models of the constituent reactions predict the rate of motion.
Journal ArticleDOI
Collective cell migration in morphogenesis, regeneration and cancer
Peter Friedl,Darren Gilmour +1 more
TL;DR: Comparing different types of collective migration at the molecular and cellular level reveals a common mechanistic theme between developmental and cancer research.
Journal ArticleDOI
A brain-specific microRNA regulates dendritic spine development
Gerhard Schratt,Fabian Tuebing,Elizabeth A. Nigh,Elizabeth A. Nigh,Christina G. Kane,Christina G. Kane,Mary E. Sabatini,Michael A. Kiebler,Michael E. Greenberg,Michael E. Greenberg +9 more
TL;DR: It is shown that a brain-specific microRNA, miR-134>, is localized to the synapto-dendritic compartment of rat hippocampal neurons and negatively regulates the size of dendritic spines—postsynaptic sites of excitatory synaptic transmission.