Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.
TLDR
The CD8+ effector cells raised in the CD4 subset- deficient host were able of clear vital tissues from productive infection and to restrict asymptomatic, persistent infection to acinar glandular epithelial cells in salivary gland tissue.Abstract:
We have established a murine model system for exploring the ability of a CD4 subset-deficient host to cope with cytomegalovirus infection, and reported three findings. First, an antiviral response of the CD8 subset of T lymphocytes could be not only initiated but also maintained for a long period of time despite a continued absence of the CD4 subset, whereas the production of antiviral antibody proved strictly dependent upon help provided by the CD4 subset. Second, no function in the defense against infection could be ascribed as yet to CD4-CD8- T lymphocytes, which were seen to accumulate to a new subset as a result of depletion of the CD4 subset. This newly arising subset did not substitute for CD4+ T lymphocytes in providing help to B lymphocytes, and was also not effective in controlling the spread of virus in host tissues. As long as a function of these cells in the generation and maintenance of a CD8 subset-mediated response is not disproved, caution is indicated with concern to an autonomy of the CD8 subset. Third, even though with delay, the CD8+ effector cells raised in the CD4 subset-deficient host were able of clear vital tissues from productive infection and to restrict asymptomatic, persistent infection to acinar glandular epithelial cells in salivary gland tissue.read more
Citations
More filters
Journal ArticleDOI
Control of Murine Cytomegalovirus Infection by γδ T Cells
TL;DR: It is shown that mice that lack CD8 and CD4 αβ-T cells as well as B lymphocytes can control a CMV infection that is lethal in RAG-1-/- mice lacking any T- and B-cells, which provides clear evidence that γδ T cells can provide an effective control mechanism of acute CMV infections.
Journal ArticleDOI
The Role of Reticulons in Neurodegenerative Diseases
TL;DR: This review summarizes the latest discoveries on RTNs in human pathophysiology, and the engagement of these in neurodegeneration, along with the implications of these findings for a better understanding of the molecular events triggered by RTNs and their potential exploitation as next-generation therapeutics.
Journal ArticleDOI
Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells
TL;DR: This review will focus on the chromatin status of Ifng promoter in CD8 T cells and possible influences of epigenetic modifications in Ifng gene and conserved noncoding sequences (CNSs) in regulation of IFN-γ production byCD8 T lymphocytes.
Journal ArticleDOI
Cytomegalovirus associated oral ulcerations in HIV-infected patients.
TL;DR: Oral ulcerations associated with disseminated cytomegalovirus (CMV) infection were observed in four patients with AIDS manifestations showing low CD4 counts and despite the local invasion with immunocytes and high serum titers of serum antibodies the patients experienced progressive CMV disease.
Journal ArticleDOI
CD43 Collaborates with P-Selectin Glycoprotein Ligand-1 to Mediate E-Selectin-Dependent T Cell Migration into Inflamed Skin
Masanori Matsumoto,Akiko Shigeta,Yuko Furukawa,Toshiyuki Tanaka,Masayuki Miyasaka,Takako Hirata +5 more
TL;DR: It is demonstrated that the CD43 expressed on activated T cells functions as an E-selectin ligand and thereby mediates T cell migration to inflamed sites, in collaboration with PSGL-1.
References
More filters
Journal ArticleDOI
Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity
D P Dialynas,D B Wilde,Philippa Marrack,A. Pierres,Katherine A. Wall,Wendy L. Havran,G. Otten,Michael R. Loken,Michel Pierres,John W. Kappler,F. W. Fitch +10 more
TL;DR: The properties of mAb GK1.5 (complement fixation, reactivity with all mouse strains tested, profound blocking of all class II MHC antigen-specific functions by murine T cells, usefulness for FACS analyses, and usefulness for immuno-precipitation/SDS-PAGE analyses) make it suitable for investigating both the role ofclass II M HC antigen-reactive T cells in various immunological phenomena and the mechanistic basis, at the molecular level
Journal ArticleDOI
Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer T lymphocytes.
David Klatzmann,Françoise Barré-Sinoussi,Marie-Thérèse Nugeyre,C Danquet,E Vilmer,C Griscelli,F Brun-Veziret,C. Rouzioux,Jean Claude Gluckman,J.C. Chermann +9 more
TL;DR: Virus production was associated with impaired proliferation, modulation of T3-T4 cell markers, and the appearance of cytopathic effects, providing evidence for the involvement of LAV in AIDS.
Journal ArticleDOI
Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo
TL;DR: It is shown here that unmodified monoclonal antibodies can be extremely effective at depleting cells in vivo and can be used for the selective manipulation of different aspects of the immune response.
Journal ArticleDOI
CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity.
TL;DR: MCMV disease provides the first example of a role for nonstructural herpesvirus immediate-early antigens in protective immunity, and is shown to be mediated by virus-specific CD8+ CD4-T lymphocytes.
Journal ArticleDOI
A T-cell receptor gamma/CD3 complex found on cloned functional lymphocytes.
Jannie Borst,René J. van de Griend,Johan W. van Oostveen,Siew-Lan Ang,Cornelis J. M. Melief,Jonathan G. Seidman,R. L. H. Bolhuis +6 more
TL;DR: Cloned blood lymphocytes that do not express the α- and β-chains of the T-cell receptor show MHC-unrestricted cytotoxicity and these cells carry the γ-protein, disulphide-linked either to another molecule or to itself, and associated with the CD3 complex.