Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.
TLDR
The CD8+ effector cells raised in the CD4 subset- deficient host were able of clear vital tissues from productive infection and to restrict asymptomatic, persistent infection to acinar glandular epithelial cells in salivary gland tissue.Abstract:
We have established a murine model system for exploring the ability of a CD4 subset-deficient host to cope with cytomegalovirus infection, and reported three findings. First, an antiviral response of the CD8 subset of T lymphocytes could be not only initiated but also maintained for a long period of time despite a continued absence of the CD4 subset, whereas the production of antiviral antibody proved strictly dependent upon help provided by the CD4 subset. Second, no function in the defense against infection could be ascribed as yet to CD4-CD8- T lymphocytes, which were seen to accumulate to a new subset as a result of depletion of the CD4 subset. This newly arising subset did not substitute for CD4+ T lymphocytes in providing help to B lymphocytes, and was also not effective in controlling the spread of virus in host tissues. As long as a function of these cells in the generation and maintenance of a CD8 subset-mediated response is not disproved, caution is indicated with concern to an autonomy of the CD8 subset. Third, even though with delay, the CD8+ effector cells raised in the CD4 subset-deficient host were able of clear vital tissues from productive infection and to restrict asymptomatic, persistent infection to acinar glandular epithelial cells in salivary gland tissue.read more
Citations
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IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFN-gamma and nitric oxide synthetase 2.
M. van den Broek,Martin F. Bachmann,Gabriele Köhler,Marijke Barner,R Escher,R M Zinkernagel,Manfred Kopf +6 more
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Functional roles of Syk in macrophage-mediated inflammatory responses
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The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell Response
Maja Mitrović,Jurica Arapović,Jurica Arapović,Stefan Jordan,Nassima Fodil-Cornu,Stefan Ebert,Silvia M. Vidal,Astrid Krmpotić,Matthias J. Reddehase,Stipan Jonjić +9 more
TL;DR: Increased antigen load, preservation of early cDCs' function, and higher levels of innate cytokines collectively account for an enhanced CD8+ T-cell response in C57BL/6 mice infected with a virus unable to activate NK cells via the Ly49H–m157 interaction.
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The selectin-selectin ligand axis in tumor progression.
TL;DR: It is proposed that the selectin–selectin ligand mediated interactions between cells in the tumor microenvironment constitute an axis of evil, that it be included in the list of pro malignancy factors, and that molecules associated with this axis serve as targets for cancer therapy.
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Cytomegalovirus exploits IL-10-mediated immune regulation in the salivary glands
TL;DR: The results indicate that modulating effector T cell differentiation can counteract pathogen exploitation of the mucosa, thus limiting persistent virus replication and transmission.
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Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo
TL;DR: It is shown here that unmodified monoclonal antibodies can be extremely effective at depleting cells in vivo and can be used for the selective manipulation of different aspects of the immune response.
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CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity.
TL;DR: MCMV disease provides the first example of a role for nonstructural herpesvirus immediate-early antigens in protective immunity, and is shown to be mediated by virus-specific CD8+ CD4-T lymphocytes.
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A T-cell receptor gamma/CD3 complex found on cloned functional lymphocytes.
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