Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.
TLDR
The CD8+ effector cells raised in the CD4 subset- deficient host were able of clear vital tissues from productive infection and to restrict asymptomatic, persistent infection to acinar glandular epithelial cells in salivary gland tissue.Abstract:
We have established a murine model system for exploring the ability of a CD4 subset-deficient host to cope with cytomegalovirus infection, and reported three findings. First, an antiviral response of the CD8 subset of T lymphocytes could be not only initiated but also maintained for a long period of time despite a continued absence of the CD4 subset, whereas the production of antiviral antibody proved strictly dependent upon help provided by the CD4 subset. Second, no function in the defense against infection could be ascribed as yet to CD4-CD8- T lymphocytes, which were seen to accumulate to a new subset as a result of depletion of the CD4 subset. This newly arising subset did not substitute for CD4+ T lymphocytes in providing help to B lymphocytes, and was also not effective in controlling the spread of virus in host tissues. As long as a function of these cells in the generation and maintenance of a CD8 subset-mediated response is not disproved, caution is indicated with concern to an autonomy of the CD8 subset. Third, even though with delay, the CD8+ effector cells raised in the CD4 subset-deficient host were able of clear vital tissues from productive infection and to restrict asymptomatic, persistent infection to acinar glandular epithelial cells in salivary gland tissue.read more
Citations
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Usefulness of traditional serum biomarkers for management of breast cancer patients.
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TL;DR: The continuous search for optimal in vitro conditions in order to generate clinical-grade DC with a potent immunogenic potential is discussed and the molecular and cellular mechanisms underlying adequate immune responses are explored.
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Antagonistic Roles of CD4+ and CD8+ T-Cells in 7,12-Dimethylbenz(a)anthracene Cutaneous Carcinogenesis
Nabiha Yusuf,Tahseen H. Nasti,Santosh K. Katiyar,Michael K. Jacobs,Megan D. Seibert,Alexis C. Ginsburg,Laura Timares,Hui Xu,Craig A. Elmets +8 more
TL;DR: Manipulation of T-cell subpopulations that are induced by carcinogenic chemicals, like DMBA, could be a means of preventing skin cancers caused by these agents.
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CD4+ T Cells Regulate CD8+ T Cell-Mediated Cutaneous Immune Responses by Restricting Effector T Cell Development through a Fas Ligand-Dependent Mechanism
TL;DR: It is shown that CD4+ T cells restrict the development and expansion of hapten-specific CD8-specific T cells mediating CHS responses to 2,4-dinitrofluorobenzene, and transfer of wild-type CD4-type T cells to gld mice restored the negative regulation of CD8+ T cell priming and the immune response to haPTen challenge in gld-recipient mice.
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Protumor Activities of the Immune Response: Insights in the Mechanisms of Immunological Shift, Oncotraining, and Oncopromotion
G. K. Chimal-Ramírez,G. K. Chimal-Ramírez,Nancy Adriana Espinoza-Sánchez,Nancy Adriana Espinoza-Sánchez,Ezequiel M. Fuentes-Pananá +4 more
TL;DR: Cancer prognosis correlates with densities and concentrations of protumoral populations and molecules, providing ideal targets for the intelligent design of directed preventive or anticancer therapies.
References
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TL;DR: Virus production was associated with impaired proliferation, modulation of T3-T4 cell markers, and the appearance of cytopathic effects, providing evidence for the involvement of LAV in AIDS.
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Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo
TL;DR: It is shown here that unmodified monoclonal antibodies can be extremely effective at depleting cells in vivo and can be used for the selective manipulation of different aspects of the immune response.
Journal ArticleDOI
CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity.
TL;DR: MCMV disease provides the first example of a role for nonstructural herpesvirus immediate-early antigens in protective immunity, and is shown to be mediated by virus-specific CD8+ CD4-T lymphocytes.
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A T-cell receptor gamma/CD3 complex found on cloned functional lymphocytes.
Jannie Borst,René J. van de Griend,Johan W. van Oostveen,Siew-Lan Ang,Cornelis J. M. Melief,Jonathan G. Seidman,R. L. H. Bolhuis +6 more
TL;DR: Cloned blood lymphocytes that do not express the α- and β-chains of the T-cell receptor show MHC-unrestricted cytotoxicity and these cells carry the γ-protein, disulphide-linked either to another molecule or to itself, and associated with the CD3 complex.