Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.
TLDR
The CD8+ effector cells raised in the CD4 subset- deficient host were able of clear vital tissues from productive infection and to restrict asymptomatic, persistent infection to acinar glandular epithelial cells in salivary gland tissue.Abstract:
We have established a murine model system for exploring the ability of a CD4 subset-deficient host to cope with cytomegalovirus infection, and reported three findings. First, an antiviral response of the CD8 subset of T lymphocytes could be not only initiated but also maintained for a long period of time despite a continued absence of the CD4 subset, whereas the production of antiviral antibody proved strictly dependent upon help provided by the CD4 subset. Second, no function in the defense against infection could be ascribed as yet to CD4-CD8- T lymphocytes, which were seen to accumulate to a new subset as a result of depletion of the CD4 subset. This newly arising subset did not substitute for CD4+ T lymphocytes in providing help to B lymphocytes, and was also not effective in controlling the spread of virus in host tissues. As long as a function of these cells in the generation and maintenance of a CD8 subset-mediated response is not disproved, caution is indicated with concern to an autonomy of the CD8 subset. Third, even though with delay, the CD8+ effector cells raised in the CD4 subset-deficient host were able of clear vital tissues from productive infection and to restrict asymptomatic, persistent infection to acinar glandular epithelial cells in salivary gland tissue.read more
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References
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In vivo application of recombinant interleukin 2 in the immunotherapy of established cytomegalovirus infection.
TL;DR: In vivo application of recombinant human IL-2 (rhIL-2) can enhance the antiviral effect of a limited number of CD8+T lymphocytes in prophylaxis and in therapy, when virus has already colonized host tissues.
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A nonstructural polypeptide encoded by immediate-early transcription unit 1 of murine cytomegalovirus is recognized by cytolytic T lymphocytes.
TL;DR: The results provide the first definite evidence that expression of a herpes virus IE gene encoding a regulatory protein gives rise to antigen expression detectable by specific CTL.
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Activation of latent murine cytomegalovirus infection: cocultivation, cell transfer, and the effect of immunosuppression.
TL;DR: The last two findings parallel observations of human cytomegalovirus in immunosuppressed patients and in patients receiving latently infected cells during transplantation.
Journal Article
Do L3T4+ T cells act as effector cells in protection against influenza virus infection.
TL;DR: Although no LyT 2+ cells were detected by fluorescence staining in Lyt 2+-depleted spleens, the authors could detect low levels of class I MHC-restricted influenza-specific Tc memory cells in host spleen following influenza infection, whether the early viral clearance is solely due to L3T4+ T cells is not clear.
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The T-cell receptor gamma chain-CD3 complex: implication in the cytotoxic activity of a CD3+ CD4- CD8- human natural killer clone.
TL;DR: It is reported here that a T-cell clone with natural killer (NK)-like activity, WM-14, had a disulfide bridged TCR-gamma homodimer associated with CD3 on its surface and was involved in the NK-like unrestricted killer activity.