Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.
TLDR
The CD8+ effector cells raised in the CD4 subset- deficient host were able of clear vital tissues from productive infection and to restrict asymptomatic, persistent infection to acinar glandular epithelial cells in salivary gland tissue.Abstract:
We have established a murine model system for exploring the ability of a CD4 subset-deficient host to cope with cytomegalovirus infection, and reported three findings. First, an antiviral response of the CD8 subset of T lymphocytes could be not only initiated but also maintained for a long period of time despite a continued absence of the CD4 subset, whereas the production of antiviral antibody proved strictly dependent upon help provided by the CD4 subset. Second, no function in the defense against infection could be ascribed as yet to CD4-CD8- T lymphocytes, which were seen to accumulate to a new subset as a result of depletion of the CD4 subset. This newly arising subset did not substitute for CD4+ T lymphocytes in providing help to B lymphocytes, and was also not effective in controlling the spread of virus in host tissues. As long as a function of these cells in the generation and maintenance of a CD8 subset-mediated response is not disproved, caution is indicated with concern to an autonomy of the CD8 subset. Third, even though with delay, the CD8+ effector cells raised in the CD4 subset-deficient host were able of clear vital tissues from productive infection and to restrict asymptomatic, persistent infection to acinar glandular epithelial cells in salivary gland tissue.read more
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References
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Journal ArticleDOI
Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity
D P Dialynas,D B Wilde,Philippa Marrack,A. Pierres,Katherine A. Wall,Wendy L. Havran,G. Otten,Michael R. Loken,Michel Pierres,John W. Kappler,F. W. Fitch +10 more
TL;DR: The properties of mAb GK1.5 (complement fixation, reactivity with all mouse strains tested, profound blocking of all class II MHC antigen-specific functions by murine T cells, usefulness for FACS analyses, and usefulness for immuno-precipitation/SDS-PAGE analyses) make it suitable for investigating both the role ofclass II M HC antigen-reactive T cells in various immunological phenomena and the mechanistic basis, at the molecular level
Journal ArticleDOI
Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer T lymphocytes.
David Klatzmann,Françoise Barré-Sinoussi,Marie-Thérèse Nugeyre,C Danquet,E Vilmer,C Griscelli,F Brun-Veziret,C. Rouzioux,Jean Claude Gluckman,J.C. Chermann +9 more
TL;DR: Virus production was associated with impaired proliferation, modulation of T3-T4 cell markers, and the appearance of cytopathic effects, providing evidence for the involvement of LAV in AIDS.
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Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo
TL;DR: It is shown here that unmodified monoclonal antibodies can be extremely effective at depleting cells in vivo and can be used for the selective manipulation of different aspects of the immune response.
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CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity.
TL;DR: MCMV disease provides the first example of a role for nonstructural herpesvirus immediate-early antigens in protective immunity, and is shown to be mediated by virus-specific CD8+ CD4-T lymphocytes.
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A T-cell receptor gamma/CD3 complex found on cloned functional lymphocytes.
Jannie Borst,René J. van de Griend,Johan W. van Oostveen,Siew-Lan Ang,Cornelis J. M. Melief,Jonathan G. Seidman,R. L. H. Bolhuis +6 more
TL;DR: Cloned blood lymphocytes that do not express the α- and β-chains of the T-cell receptor show MHC-unrestricted cytotoxicity and these cells carry the γ-protein, disulphide-linked either to another molecule or to itself, and associated with the CD3 complex.