Journal ArticleDOI
Sleep deprivation and hippocampal vulnerability: Changes in neuronal plasticity, neurogenesis and cognitive function
TLDR
By impairing hippocampal plasticity and function, chronically restricted and disrupted sleep contributes to cognitive disorders and psychiatric diseases.About:
This article is published in Neuroscience.The article was published on 2015-11-19. It has received 233 citations till now. The article focuses on the topics: Neuroscience of sleep & Sleep and memory.read more
Citations
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The hippocampus in aging and disease: From plasticity to vulnerability
Thorsten Bartsch,Peer Wulff +1 more
TL;DR: Basic principles of hippocampal anatomy and neuroplasticity on various levels are reviewed as well as recent findings regarding the functional organization of the hippocampus in light of the regional vulnerability in Alzheimer's disease, ischemia, epilepsy, neuroinflammation and aging.
Journal ArticleDOI
Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function.
Selena Vigano,Dimitrios Alatzoglou,Melita Irving,Christine Ménétrier-Caux,Christophe Caux,Pedro Romero,George Coukos +6 more
TL;DR: The regulation of adenosine levels and mechanisms by which it promotes tumor growth and broadly suppresses protective immunity are reviewed, with extra focus on the attenuation of T cell function.
Journal ArticleDOI
Circadian control of brain glymphatic and lymphatic fluid flow.
Lauren M. Hablitz,Virginia Plá,Michael Giannetto,Hanna S. Vinitsky,Frederik Filip Stæger,Tanner Metcalfe,Rebecca Nguyen,Abdellatif Benrais +7 more
TL;DR: It is shown that CSF distribution is under circadian control and that AQP4 supports this rhythm, suggesting distribution of CSF throughout the animal depends on time-of-day.
Journal ArticleDOI
Sleep and emotional processing.
TL;DR: Evidence converges in indicating that lack of sleep significantly influences emotional reactivity, and the processing of emotionally salient information could mainly benefit from REM sleep, although some crucial aspects of sleep-dependent emotional modulation remain unclear.
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The role of sleep in regulating structural plasticity and synaptic strength: Implications for memory and cognitive function
TL;DR: Several studies have now shown that sleep deprivation can reduce spine density and attenuate synaptic efficacy in the hippocampus, which are the basis for the view that sleep promotes hippocampal structural plasticity critical for memory formation.
References
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Journal ArticleDOI
Place navigation impaired in rats with hippocampal lesions.
TL;DR: It is reported that, in addition to a spatial discrimination impairment, total hippocampal lesions also cause a profound and lasting placenavigational impairment that can be dissociated from correlated motor, motivational and reinforcement aspects of the procedure.
Journal ArticleDOI
Neurotrophins: roles in neuronal development and function.
Eric J. Huang,Louis F. Reichardt +1 more
TL;DR: Neurotrophins regulate development, maintenance, and function of vertebrate nervous systems, and control synaptic function and synaptic plasticity, while continuing to modulate neuronal survival.
Journal ArticleDOI
Selective impairment of learning and blockade of long-term potentiation by an N -methyl-D-aspartate receptor antagonist, AP5
TL;DR: This article showed that chronic intraventricular infusion of D,L-AP5 causes a selective impairment of place learning, which is highly sensitive to hippocampal damage, without affecting visual discrimination learning.
Journal ArticleDOI
The memory function of sleep
Susanne Diekelmann,Jan Born +1 more
TL;DR: Sleep has been identified as a state that optimizes the consolidation of newly acquired information in memory, depending on the specific conditions of learning and the timing of sleep, through specific patterns of neuromodulatory activity and electric field potential oscillations.
Journal ArticleDOI
Differential Contribution of Amygdala and Hippocampus to Cued and Contextual Fear Conditioning
R. G. Phillips,Joseph E. LeDoux +1 more
TL;DR: An associative roles for the amygdala and a sensory relay role for the hippocampus are suggested in fear conditioning, which is involved in the conditioning of fear responses to simple, modality-specific conditioned stimuli as well as to complex, polymodal stimuli.
Related Papers (5)
Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration
Giulio Tononi,Chiara Cirelli +1 more