Journal ArticleDOI
Sodium butyrate inhibits the NF-kappa B signaling pathway and histone deacetylation, and attenuates experimental colitis in an IL-10 independent manner.
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TLDR
The results indicate that oral supplementation with butyrate attenuates experimental murine colitis by blocking NF‐&kgr;B signaling and reverses histone acetylation, and may therefore be a therapeutic agent for colitis.About:
This article is published in International Immunopharmacology.The article was published on 2017-10-01. It has received 136 citations till now. The article focuses on the topics: Sodium butyrate & Butyrate.read more
Citations
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Journal ArticleDOI
Postbiotics-A Step Beyond Pre- and Probiotics.
TL;DR: A critical review of postbiotics described in the literature, including their mechanisms of action, clinical characteristics, and potential therapeutic applications is provided.
Journal ArticleDOI
Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation
Vishal Singh,Beng San Yeoh,Rachel E Walker,Xia Xiao,Piu Saha,Rachel M. Golonka,Jingwei Cai,Alexis Bretin,Xi Cheng,Qing Liu,Michael D. Flythe,Benoit Chassaing,Gregory C. Shearer,Andrew D. Patterson,Andrew T. Gewirtz,Matam Vijay-Kumar +15 more
TL;DR: The notion that fermentable fibres have the potential to ameliorate colitis is supported but it is cautioned that, in some contexts, prebiotic fibres can lead to gut dysbiosis and surfeit colonic butyrate that might exacerbate IBD.
Journal ArticleDOI
Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule
Sabrina Chriett,Arkadiusz Dąbek,Martyna Wojtala,Hubert Vidal,Aneta Balcerczyk,Luciano Pirola +5 more
TL;DR: It is confirmed that butyrate is a strong HDAC inhibitor and had an extensive impact on gene transcription in rat myotubes, upregulating PGC1α, CPT1b, mitochondrial sirtuins (SIRT3-5), and the mitochondrial anti-oxidative genes SOD2 and catalase.
Journal ArticleDOI
Sodium butyrate abolishes lipopolysaccharide-induced depression-like behaviors and hippocampal microglial activation in mice.
Yosuke Yamawaki,Yosuke Yamawaki,Norika Yoshioka,Kanako Nozaki,Hikaru Ito,Keisuke Oda,Kana Harada,Satomi Shirawachi,Satoshi Asano,Hidenori Aizawa,Shigeto Yamawaki,Takashi Kanematsu,Hiroyuki Akagi +12 more
TL;DR: It is suggested that epigenetic regulation exist in hippocampal microglial activation, and is involved in depressive-like behaviors associated with neuro-inflammation.
Journal ArticleDOI
Fatty acids, epigenetic mechanisms and chronic diseases: a systematic review.
Karina González-Becerra,Omar Ramos-Lopez,Omar Ramos-Lopez,Elisa Barrón-Cabrera,José-Ignacio Riezu-Boj,Fermín I. Milagro,Fermín I. Milagro,Erika Martinez-Lopez,J A Martínez +8 more
TL;DR: Fatty acids can regulate gene expression by modifying epigenetic mechanisms and consequently result in positive or negative impacts on metabolic outcomes, according to the PRISMA-P guidelines.
References
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Journal ArticleDOI
Interleukin-10-deficient mice develop chronic enterocolitis
TL;DR: The results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract.
Journal ArticleDOI
Review article: the role of butyrate on colonic function
Henrike M. Hamer,Daisy Jonkers,Koen Venema,Steven Vanhoutvin,Freddy J. Troost,Robert Brummer +5 more
TL;DR: Butyrate is an important energy source for intestinal epithelial cells and plays a role in the maintenance of colonic homeostasis, and is a main end‐product of intestinal microbial fermentation of mainly dietary fibre.
Journal ArticleDOI
The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition
TL;DR: It is demonstrated that the short-chain fatty acid n-butyrate, which is secreted in high amounts by commensal bacteria, can modulate the function of intestinal macrophages, the most abundant immune cell type in the lamina propria, and elucidate a pathway in which the host may maintain tolerance to intestinal microbiota by rendering lamina Propria macrophage hyporesponsive to commensals through the down-regulation of proinflammatory effectors.
Journal ArticleDOI
Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines
L. A. Dieleman,M. J. H. J. Palmen,H Akol,Elisabeth Bloemena,Amado Salvador Peña,Stefan G. M. Meuwissen,E. P. Van Rees +6 more
TL;DR: It is postulate that chronic immune activation mediated by both populations of Th cells can interfere with colonic healing and can play a role in the pathogenesis of chronic colitis.
Journal ArticleDOI
Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature.
TL;DR: High dietary intakes of total fats, PUFAs, omega-6 fatty acids, and meat were associated with an increased risk of CD and UC, and high vegetable intake was associated with decreased UC risk.
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