Journal ArticleDOI
Specific proteome changes in platelets from individuals with GATA1-, GFI1B-, and RUNX1-linked bleeding disorders
M G J M Van Bergen,Anna E. Marneth,Anna E. Marneth,AJ Hoogendijk,F P J van Alphen,E. van den Akker,B. A. P. Laros-van Gorkom,M Hoeks,Annet Simons,S.A. de Munnik,Jeroen Janssen,Joost H.A. Martens,Joop H. Jansen,Alexander B. Meijer,B.A. van der Reijden +14 more
TLDR
In this paper, the authors provide a quantitative landscape of proteins that affect platelet function when deregulated by mutated transcription factors in inherited bleeding disorders, including GATA binding factor (GATA1), growth factor independence (GFI1B), and Runt-related transcription factor (RUNX1).About:
This article is published in Blood.The article was published on 2021-07-08. It has received 7 citations till now. The article focuses on the topics: Blood Platelet Disorders & Platelet.read more
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Journal ArticleDOI
Molecular Proteomics and Signalling of Human Platelets in Health and Disease.
Jingnan Huang,Jingnan Huang,Jingnan Huang,Pengyu Zhang,Pengyu Zhang,Pengyu Zhang,Fiorella A. Solari,Albert Sickmann,Albert Sickmann,Albert Sickmann,Ángel García,Kerstin Jurk,Johan W. M. Heemskerk +12 more
TL;DR: In this paper, the authors review 67 reports regarding platelet proteomic analysis and signalling on a molecular base and provide detailed insight into the technical developments and limitations of the assessment of platelet (sub)proteomes.
Journal ArticleDOI
Effects of ex vivo blood anticoagulation and preanalytical processing time on the proteome content of platelets
Samuel Tassi Yunga,Austin J. Gower,Alexander R. Melrose,Meghan K Fitzgerald,Ashmitha Rajendran,Theresa A. Lusardi,Randall Armstrong,Jessica Minnier,Kelley Jordan,Owen J. T. McCarty,Larry L. David,Phillip A. Wilmarth,Ashok P. Reddy,Joseph E. Aslan +13 more
TL;DR: Ex vivo assays of platelet function critically inform mechanistic and clinical hematology studies, where effects of divergent blood processing methods on platelet composition are apparent, but unspecified.
Journal ArticleDOI
Proteomic landscapes of inherited platelet disorders with different etiologies.
Iris C. Kreft,Elise J. Huisman,Marjon H. Cnossen,Floris P. J. van Alphen,Carmen van der Zwaan,Karin van Leeuwen,Rosalina M. L. van Spaendonk,Leendert Porcelijn,Caroline S B Veen,Maartje van den Biggelaar,M. de Haas,Alexander B. Meijer,Arie J. Hoogendijk +12 more
TL;DR: In this article , the authors performed MS-based proteome profiling on platelets of 34 patients with hereditary platelet disorders (IPDs) with variants in 13 ISTH TIER1 genes that affect different stages of platelet development.
Journal ArticleDOI
Metformin Relieves Bortezomib-Induced Neuropathic Pain by Regulating AMPKa2-Mediated Autophagy in the Spinal Dorsal Horn
TL;DR: It is shown that metformin relieves bortezomib (BTZ)-evoked induction and maintenance of neuropathic pain by preventing the reduction in the expression of Beclin-1, an autophagy marker, in the spinal dorsal horn.
Journal ArticleDOI
Proteomics-wise, how similar are mouse and human platelets?
TL;DR: In this article , the mouse and human platelet proteomes and secretomes from public databases are compared, which shows that human and mouse platelets share a highly conserved proteome, considering identified proteins, and most importantly, their relative abundance.
References
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Journal ArticleDOI
The ENCODE (ENCyclopedia of DNA elements) Project
Elise A. Feingold,Peter J. Good,Mark S. Guyer,S. Kamholz,L. Liefer,Kris A. Wetterstrand,Francis S. Collins,Thomas R. Gingeras,Dione Kampa,E. A. Sekinger,Jill Cheng,H. Hirsch,Srinka Ghosh,Zhou Zhu,Sandeep Patel,Antonio Piccolboni,A. Yang,Hari Tammana,Stefan Bekiranov,Philipp Kapranov,Rhonda Harrison,George M. Church,Kevin Struhl,Bing Ren,Tae Hoon Kim,Leah O. Barrera,Chunxu Qu,S. van Calcar,R. Luna,C. K. Glass,M. G. Rosenfeld,Roderic Guigó,Stylianos E. Antonarakis,Ewan Birney,Michael R. Brent,Lior Pachter,Alexandre Reymond,Emmanouil T. Dermitzakis,Colin N. Dewey,Damian Keefe,F. Denoeud,Julien Lagarde,Jennifer L. Ashurst,Tim Hubbard,Jan-Jaap Wesselink,Robert Castelo,Eduardo Eyras,Richard M. Myers,Arend Sidow,Serafim Batzoglou,Nathan D. Trinklein,Sara J. Hartman,Shelley Force Aldred,Elizabeth Anton,Diane I. Schroeder,S. S. Marticke,Long H. Nguyen,Jeremy Schmutz,Jane Grimwood,Mark Dickson,Gregory M. Cooper,Eric A. Stone,George Asimenos,Michael Brudno,Anindya Dutta,Neerja Karnani,Christopher M. Taylor,H. K. Kim,Gabriel Robins,George Stamatoyannopoulos,John A. Stamatoyannopoulos,Michael O. Dorschner,Peter J. Sabo,Michael Hawrylycz,Richard Humbert,James C. Wallace,Min-Feng Yu,Patrick A. Navas,M. McArthur,William Stafford Noble,Ian Dunham,Christof Koch,Robert M. Andrews,Gayle K. Clelland,Sarah Wilcox,Joanna C. Fowler,Keith D. James,P. Groth,Oliver M. Dovey,Peter D. Ellis,Vicki L. Wraight,Andrew J. Mungall,Pawandeep Dhami,Heike Fiegler,Cordelia Langford,Nigel P. Carter,David Vetrie,Michael Snyder,Ghia Euskirchen,Alexander E. Urban,Ugrappa Nagalakshmi,John L. Rinn,George V. Popescu,Paul Bertone,Stephen Hartman,Joel Rozowsky,Olof Emanuelsson,Thomas Royce,Sambath Chung,Mark Gerstein,Zheng Lian,Jane B. Lian,Y. Nakayama,Sherman M. Weissman,Viktor Stolc,W. Tongprasit,H. Sethi,Steven J.M. Jones,Marco A. Marra,H. Shin,Jacquie Schein,Michele Clamp,Kerstin Lindblad-Toh,Jean L. Chang,David B. Jaffe,Michael Kamal,Eric S. Lander,Tarjei S. Mikkelsen,Jade P. Vinson,Michael C. Zody,P. J. De Jong,Kazutoyo Osoegawa,Mikhail Nefedov,Baoli Zhu,Andreas D. Baxevanis,Tyra G. Wolfsberg,Gregory E. Crawford,James R R Whittle,Ingeborg Holt,T. J. Vasicek,D. Zhou,Shu-Jin Luo,Eric D. Green,Gerry Bouffard,Elliott H. Margulies,Matthew E. Portnoy,Nancy F. Hansen,Pamela J. Thomas,Jenny McDowell,Baishali Maskeri,Alice C. Young,Jacquelyn R. Idol,Robert W. Blakesley,Greg Schuler,Webb Miller,Ross C. Hardison,Laura Elnitski,Prachi Shah,Steven L. Salzberg,Mihaela Pertea,William H. Majoros,David Haussler,Daryl J. Thomas,Kate R. Rosenbloom,Hiram Clawson,Adam Siepel,W. J. Kent,Zhiping Weng,S. Jin,Anason S. Halees,H. Burden,Ulas Karaoz,Yutao Fu,Yong Yu,C. Ding,Charles R. Cantor,Robert E. Kingston,Jonathan H. Dennis,Roland Green,Michael A. Singer,Todd Richmond,J. E. Norton,Peggy J. Farnham,Matthew J. Oberley,D. R. Inman,M. R. McCormick,H. Kim,C. L. Middle,Michael C. Pirrung,Xiang-Dong Fu,Y. S. Kwon,Z. Ye,Job Dekker,Tomoko M. Tabuchi,Nele Gheldof,Josée Dostie,S. C. Harvey +196 more
TL;DR: The ENCyclopedia Of DNA Elements (ENCODE) Project is organized as an international consortium of computational and laboratory-based scientists working to develop and apply high-throughput approaches for detecting all sequence elements that confer biological function.
Journal ArticleDOI
Proteomic analysis of platelet alpha-granules using mass spectrometry.
TL;DR: The method provided a suitable tool for analyzing the granule proteome of patients with storage pool deficiencies and identified 284 non‐redundant proteins, 44 of which appear to be new α‐granule proteins, on the basis of a literature review.
Journal ArticleDOI
Genome-wide Analysis of Simultaneous GATA1/2, RUNX1, FLI1, and SCL Binding in Megakaryocytes Identifies Hematopoietic Regulators
Marloes R. Tijssen,Marloes R. Tijssen,Ana Cvejic,Ana Cvejic,Anagha Joshi,Rebecca Hannah,Rita Ferreira,Ariel Forrai,Dana C. Bellissimo,Dana C. Bellissimo,S. Helen Oram,Peter A. Smethurst,Nicola K. Wilson,Xiaonan Wang,Katrin Ottersbach,Derek L. Stemple,Anthony R. Green,Willem H. Ouwehand,Willem H. Ouwehand,Berthold Göttgens +19 more
TL;DR: Multifactor ChIP-Seq analysis in primary human cells coupled with a high-throughput in vivo perturbation screen offers a powerful strategy to identify essential regulators of complex mammalian differentiation processes.
Journal ArticleDOI
X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction
Channing Yu,Kathy K. Niakan,Mark Matsushita,George Stamatoyannopoulos,Stuart H. Orkin,Wendy H. Raskind +5 more
TL;DR: It is suggested that residues of the N finger of Gata-1-facing DNA contribute to GATA-1 function apart from interaction with the cofactor FOG-1, the first example of beta-thalassemia in humans caused by a mutation in an erythroid transcription factor.
Journal ArticleDOI
A dominant-negative GFI1B mutation in the gray platelet syndrome
Davide Monteferrario,Nikhita Ajit Bolar,Anna E. Marneth,Konnie M. Hebeda,Saskia M. Bergevoet,Hans Veenstra,Britta A P Laros-van Gorkom,M.A. MacKenzie,Cyrus Khandanpour,Lacramiora Botezatu,Erik Fransen,Guy Van Camp,Anthonie L. Duijnhouwer,Simone Salemink,Brigith Willemsen,Gerwin Huls,Frank Preijers,Waander L. van Heerde,Joop H. Jansen,Marlies Kempers,Bart Loeys,Lut Van Laer,Bert A. van der Reijden +22 more
TL;DR: The studies show that GFI1B, in addition to being causally related to the gray platelet syndrome, is key to megakaryocyte and platelet development.
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