Static Magnetic Field Stimulation Enhances Oligodendrocyte Differentiation and Secretion of Neurotrophic Factors
Ankshita Prasad,Daniel Boon Loong Teh,Agata Blasiak,Chou Chai,Yang Wu,Payam Gharibani,In Hong Yang,In Hong Yang,Thang T. Phan,Kah-Leong Lim,Hyunsoo Yang,Xiaogang Liu,Angelo H. All +12 more
TLDR
The ability of glial cells such as OPCs to positively respond to moderate intensity SMF stimulation by exhibiting enhanced differentiation, functionality as well as neurotrophic factor release is emphasized.Abstract:
The cellular-level effects of low/high frequency oscillating magnetic field on excitable cells such as neurons are well established. In contrast, the effects of a homogeneous, static magnetic field (SMF) on Central Nervous System (CNS) glial cells are less investigated. Here, we have developed an in vitro SMF stimulation set-up to investigate the genomic effects of SMF exposure on oligodendrocyte differentiation and neurotrophic factors secretion. Human oligodendrocytes precursor cells (OPCs) were stimulated with moderate intensity SMF (0.3 T) for a period of two weeks (two hours/day). The differential gene expression of cell activity marker (c-fos), early OPC (Olig1, Olig2. Sox10), and mature oligodendrocyte markers (CNP, MBP) were quantified. The enhanced myelination capacity of the SMF stimulated oligodendrocytes was validated in a dorsal root ganglion microfluidics chamber platform. Additionally, the effects of SMF on the gene expression and secretion of neurotrophic factors- BDNF and NT3 was quantified. We also report that SMF stimulation increases the intracellular calcium influx in OPCs as well as the gene expression of L-type channel subunits-CaV1.2 and CaV1.3. Our findings emphasize the ability of glial cells such as OPCs to positively respond to moderate intensity SMF stimulation by exhibiting enhanced differentiation, functionality as well as neurotrophic factor release.read more
Citations
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A Review of Functional Electrical Stimulation Treatment in Spinal Cord Injury
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Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of Inflammation.
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Transcranial Static Magnetic Field Stimulation over the Primary Motor Cortex Induces Plastic Changes in Cortical Nociceptive Processing.
Hikari Kirimoto,Hiroyuki Tamaki,Naufumi Otsuru,Koya Yamashiro,Hideaki Onishi,Ippei Nojima,Antonio Oliviero +6 more
TL;DR: Although the results of intervention for experimental acute pain in healthy subjects cannot be directly translated into the clinical situation, tSMS may be a potentially useful NIBS method for managing chronic pain, in addition to standard of care treatments.
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Recent Developments in Prosthesis Sensors, Texture Recognition, and Sensory Stimulation for Upper Limb Prostheses.
TL;DR: A review article is on recent developments while including foundational knowledge for some of the critical concepts in neural prostheses, with emphasis on texture recognition and sensory stimulation strategies that reestablish the lost sensory feedback loop.
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The Regenerative Effect of Trans-spinal Magnetic Stimulation After Spinal Cord Injury: Mechanisms and Pathways Underlying the Effect.
C. Chalfouh,C. Guillou,J. Hardouin,Q. Delarue,Xiaofei Li,C. Duclos,D. Schapman,Jean-Paul Marie,P. Cosette,N. Guérout +9 more
TL;DR: Evidence is provided that repetitive trans-spinal magnetic stimulation can be a noninvasive SCI treatment that enhances tissue repair and functional recovery and induces therapeutic effects in a preclinical rodent model and suggests possible translation to clinical application in humans.
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