Journal ArticleDOI
Structural vaccinology approach to investigate the virulent and secretory proteins of Bacillus anthracis for devising anthrax next-generation vaccine
TLDR
Abstract Communicated by Ramaswamy H. Sarma is a post-graduate student of electrical engineering at the University of California, Berkeley and a member of the faculty at the California Institute of Technology, Berkeley.Abstract:
Abstract Communicated by Ramaswamy H. Sarmaread more
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Designing of a multi-epitope vaccine candidate against Nipah virus by in silico approach: a putative prophylactic solution for the deadly virus
TL;DR: A stable multivalent vaccine combining several T-cell and B-cell epitopes of the essential Nipah viral proteins with the help of different ligands and adjuvants which can effectively induce both humoral and cellular immune responses in human is designed.
Journal ArticleDOI
Receptor-ligand based molecular interaction to discover adjuvant for immune cell TLRs to develop next-generation vaccine.
TL;DR: The significance of the study deals with the identification of adjuvant (ligand) for human TLRs individually which assist in the development of the optimal highly immunogenic vaccine.
Journal ArticleDOI
Identification of novel and selective agonists for ABA receptor PYL3.
TL;DR: The structural basis of the binding mechanism of 3-methyleneisoindolin-1-one molecules with ABA receptors is revealed and Mol26 and Mol25 were identified for the development of specific PYL3 agonists with a vast potential in agriculture to accentuate the ABA like action in plants.
Journal ArticleDOI
A multi-epitope chimeric protein elicited a strong antibody response and partial protection against Edwardsiella ictaluri in Nile tilapia.
Vimbai Irene Machimbirike,Natapol Pornputtapong,Saengchan Senapin,Saengchan Senapin,Eakapol Wangkahart,Prapansak Srisapoome,Pongsak Khunrae,Triwit Rattanarojpong +7 more
TL;DR: In this article, an immunoinformatic approach was employed to design a cross-immunogenic chimeric EiCh protein containing multi-epitopes, which is composed of 11 B-cell epitopes and 7 major histocompatibility complex class II epitopes identified from E.ictaluri immunogenic proteins previously reported.
Journal ArticleDOI
In silico potential of nutraceutical plant of Pithecellobium dulce against GRP78 target protein for breast cancer
Selvakumar Murugesan,Palanikumar Palanichamy,Velusamy Arumugam,Manigandan Venkatesan,Surya Aathmanathan,Hemanandini Krishnamoorthy,Arivalagan Pugazhendhi +6 more
TL;DR: A preliminary phytochemical screening of the EtOH extract of the Pithecellobium dulce fruit peel showed the presence of alkaloids, glycosides, flavonoids, steroids, tannins, saponin and polyphenols.
References
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Journal ArticleDOI
AlgPred: prediction of allergenic proteins and mapping of IgE epitopes.
TL;DR: In this study a systematic attempt has been made to integrate various approaches in order to predict allergenic proteins with high accuracy using MEME/MAST software and a database of known IgE epitopes was searched and this predicted allergen proteins with 17.47% sensitivity at specificity.
Journal ArticleDOI
Macrophage Apoptosis by Anthrax Lethal Factor Through p38 MAP Kinase Inhibition
TL;DR: It is found that B. anthracis lethal factor selectively induces apoptosis of activated macrophages by cleaving the amino-terminal extension of mitogen-activated protein kinase (MAPK) kinases (MKKs) that activate p38 MAPKs.
Journal ArticleDOI
Anthrolysin O and other gram-positive cytolysins are Toll-like receptor 4 agonists
TL;DR: Recombinant ALO can activate TLR4 in a manner independent of LPS contamination and, together with LT, can induce macrophage apoptosis and genetic evidence that ALO is required for induction of macrophages apoptosis in response to infection with live B. anthracis is provided.
Journal ArticleDOI
PAProC: a prediction algorithm for proteasomal cleavages available on the WWW.
Alexander K. Nussbaum,Christina Kuttler,Karl-Peter Hadeler,Hans-Georg Rammensee,Hansjörg Schild +4 more
TL;DR: PAProC is a prediction tool for cleavages by human and yeast proteasomes, based on experimental cleavage data, that will be particularly useful for immunologists working on antigen processing and the prediction of major histocompatibility complex class I molecule (MHC I) ligands and cytotoxic T-lymphocyte (CTL) epitopes.
Book ChapterDOI
New directions in nicotine vaccine design and use.
Paul R. Pentel,Mark G. LeSage +1 more
TL;DR: A wide array of next-generation strategies are being evaluated to enhance vaccine efficacy or provide antibody through other mechanisms, including viral vector-mediated transfer of genes for antibody production, which may present an alternative to vaccination or passive immunization.