Surgery after Induction Targeted Therapy and Immunotherapy for Lung Cancer
TLDR
In this article, a thorough literature review was performed, analyzing all recent studies regarding surgical morbidity and mortality regarding non-small cell lung cancer (NSCLC) patients with ipsilateral positive mediastinal nodes.Abstract:
Multimodality therapy for locally advanced non-small cell lung cancer (NSCLC) is a complex and controversial issue, especially regarding optimal treatment regimens for patients with ipsilateral positive mediastinal nodes (N2 disease) Many trials investigating neoadjuvant immunotherapy and targeted therapy in this subpopulation have shown promising results, although concerns have risen regarding surgical feasibility A thorough literature review was performed, analyzing all recent studies regarding surgical morbidity and mortality Despite the fact that two major trials investigating this subject were terminated early, the overall consensus is that surgical management seems feasible However, dissection of hilar vessels may be challenging due to hilar fibrosis Further research is necessary to identify the role of surgery in these multimodality treatment regimens, and to define matters such as the optimal treatment regimen, the dosage of the different agents used, the interval between induction therapy and surgery, and the role of adjuvant therapyread more
Citations
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The Role of Surgery in Lung Cancer Treatment: Present Indications and Future Perspectives-State of the Art.
TL;DR: The role of surgery and surgeons has also evolved because surgeons not only perform the initial curative lung cancer resection but they also accompany and follow-up patients from pre-operative rehabilitation, to treatment for recurrences as discussed by the authors.
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Chimeric Antigen Receptor T-Cell Therapy in Lung Cancer: Potential and Challenges.
TL;DR: In this article, the authors focused on the latest research progress of CAR-T cell therapy in lung cancer treatment and for the first time, demonstrated the underlying challenges and future engineering strategies for the clinical application ofCAR-T-cell therapy against lung cancer.
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Multimodality Treatment including Surgery Related to the Type of N2 Involvement in Locally Advanced Non-Small Cell Lung Cancer
Toon Allaeys,Lawek Berzenji,Patrick Lauwers,Suresh Krishan Yogeswaran,Jeroen M.H. Hendriks,Charlotte Billiet,Charlotte De Bondt,Paul Van Schil +7 more
TL;DR: The latest data on multimodality treatment options for stage IIIA-N2 locally advanced NSCLC, depending on the extent of nodal involvement is summarized.
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TL;DR: Durvalumab therapy resulted in significantly longer overall survival than placebo, and no new safety signals were identified.
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Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
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TL;DR: The Clatterbridge Cancer Centre and Liverpool Heart and Chest Hospital, Liverpool; University of Aberdeen, Aberdeen, UK; Center for Medical Imaging, University of Groningen, Groningen; Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands; and Department of Thoracic Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK.
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